Compounds > fenfluramine
Page last updated: 2024-10-27

fenfluramine and HIV Infections

fenfluramine has been researched along with HIV Infections in 2 studies

Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.

HIV Infections: Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (50.00)18.2507
2000's1 (50.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Nightingale, SL1
Humbert, M1
Nunes, H1
Sitbon, O1
Parent, F1
Hervé, P1
Simonneau, G1

Reviews

1 review available for fenfluramine and HIV Infections

ArticleYear
Risk factors for pulmonary arterial hypertension.
    Clinics in chest medicine, 2001, Volume: 22, Issue:3

    Topics: Altitude; Aminorex; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents, Second-

2001

Other Studies

1 other study available for fenfluramine and HIV Infections

ArticleYear
From the Food and Drug Administration.
    JAMA, 1996, Jul-03, Volume: 276, Issue:1

    Topics: Advertising; AIDS Serodiagnosis; Appetite Depressants; Consumer Product Safety; Fenfluramine; HIV In

1996