fenfluramine has been researched along with Glial Cell Tumors in 1 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We have studied the induction of an amiloride-sensitive sodium influx into C6 glioma, NIE, and NB2A neuroblastoma cell lines." | 7.66 | Characteristics of an amiloride-sensitive sodium entry pathway in cultured rodent glial and neuroblastoma cells. ( Benos, DJ; Sapirstein, VS, 1983) |
| "We have studied the induction of an amiloride-sensitive sodium influx into C6 glioma, NIE, and NB2A neuroblastoma cell lines." | 3.66 | Characteristics of an amiloride-sensitive sodium entry pathway in cultured rodent glial and neuroblastoma cells. ( Benos, DJ; Sapirstein, VS, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Benos, DJ | 1 |
| Sapirstein, VS | 1 |
1 other study available for fenfluramine and Glial Cell Tumors
| Article | Year |
|---|---|
Characteristics of an amiloride-sensitive sodium entry pathway in cultured rodent glial and neuroblastoma cells.
Topics: Amiloride; Animals; Biological Transport; Blood; Calcimycin; Cell Division; Cell Line; Cycloheximide | 1983 |