fenfluramine has been researched along with Genetic Predisposition in 6 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Precapillary pulmonary hypertension is defined by an increase in mPAP > or =25 mmHg and a pulmonary capillary wedge pressure (PCWP)< or =15 mmHg associated with a normal or reduced cardiac output." | 1.36 | [Diagnosis and classification of pulmonary hypertension]. ( Chaouat, A; Montani, D, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Souza, R | 1 |
| Jardim, C | 1 |
| Humbert, M | 1 |
| Montani, D | 1 |
| Chaouat, A | 1 |
| Halperin, JM | 1 |
| Schulz, KP | 1 |
| McKay, KE | 1 |
| Sharma, V | 1 |
| Newcorn, JH | 1 |
| Etienne, N | 1 |
| Schaerlinger, B | 1 |
| Jaffré, F | 1 |
| Maroteaux, L | 1 |
| Buydens-Branchey, L | 1 |
| Branchey, M | 1 |
| Hudson, J | 1 |
| Rothman, M | 1 |
| Fergeson, P | 1 |
| McKernin, C | 1 |
| Hilts, PJ | 1 |
1 review available for fenfluramine and Genetic Predisposition
| Article | Year |
|---|---|
[The 5-HT2B receptor: a main cardio-pulmonary target of serotonin].
Topics: Adult; Animals; Cardiomyopathy, Dilated; Cell Survival; Fenfluramine; Fetal Heart; Genes, Lethal; Ge | 2004 |
1 trial available for fenfluramine and Genetic Predisposition
| Article | Year |
|---|---|
Serotonergic function in cocaine addicts: prolactin responses to sequential D,L-fenfluramine challenges.
Topics: Administration, Oral; Adult; Alcoholism; Child of Impaired Parents; Cocaine-Related Disorders; Fathe | 1999 |
4 other studies available for fenfluramine and Genetic Predisposition
| Article | Year |
|---|---|
Idiopathic pulmonary arterial hypertension.
Topics: Aminorex; Antihypertensive Agents; Appetite Depressants; Bosentan; Dasatinib; Epoprostenol; Familial | 2013 |
[Diagnosis and classification of pulmonary hypertension].
Topics: Activin Receptors, Type II; Anemia, Hemolytic; Bone Morphogenetic Protein Receptors, Type II; Cardia | 2010 |
Familial correlates of central serotonin function in children with disruptive behavior disorders.
Topics: Aggression; Attention Deficit and Disruptive Behavior Disorders; Child; Child Behavior Disorders; Fe | 2003 |
Experiments on children are reviewed: research involved now-banned drug.
Topics: Advisory Committees; Aggression; Behavioral Research; Black or African American; Child; Federal Gove | 1998 |