fenfluramine has been researched along with Froehlich's Syndrome in 4 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Leshem, M | 1 |
| Stunkard, AJ | 1 |
| Nappi, RE | 1 |
| Petraglia, F | 1 |
| Genazzani, AD | 1 |
| D'Ambrogio, G | 1 |
| Zara, C | 1 |
| Genazzani, AR | 1 |
| Jordaan, GP | 1 |
| Roberts, MC | 1 |
| Emsley, RA | 1 |
1 review available for fenfluramine and Froehlich's Syndrome
| Article | Year |
|---|---|
Anorectic agents lower a body weight set point.
Topics: Animals; Appetite Depressants; Appetite Regulation; Behavior Therapy; Body Weight; Dextroamphetamine | 1982 |
3 other studies available for fenfluramine and Froehlich's Syndrome
| Article | Year |
|---|---|
Morphine-induced anorexia in lateral hypothalamic rats.
Topics: Amphetamine; Animals; Anorexia; Dextroamphetamine; Feeding and Eating Disorders; Fenfluramine; Human | 1981 |
Hypothalamic amenorrhea: evidence for a central derangement of hypothalamic-pituitary-adrenal cortex axis activity.
Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Amenorrhea; Corticotropin-Releasing Hormone; Female; | 1993 |
Serotonergic agents in the treatment of hypothalamic obesity syndrome: a case report.
Topics: Adult; Body Weight; Brain Damage, Chronic; Dose-Response Relationship, Drug; Fenfluramine; Fluoxetin | 1996 |