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fenfluramine and Fasting Hypoglycemia

fenfluramine has been researched along with Fasting Hypoglycemia in 4 studies

Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.

Fasting Hypoglycemia: HYPOGLYCEMIA expressed in the postabsorptive state, after prolonged FASTING, or an overnight fast.

Research Excerpts

ExcerptRelevanceReference
" We hypothesized that CFS is mediated by changes in hypothalamopituitary function and so measured the adrenocorticotrophic hormone (ACTH), cortisol, growth hormone, and prolactin responses to insulin-induced hypoglycemia, and the ACTH, cortisol, and prolactin responses to serotoninergic stimulation with dexfenfluramine in nondepressed CFS patients and normal controls."7.69Neuroendocrine responses to d-fenfluramine and insulin-induced hypoglycemia in chronic fatigue syndrome. ( Allain, T; Bearn, J; Butler, J; Coskeran, P; McGregor, A; Munro, N; Wessely, S, 1995)
"In order to study the hypothesized impairment of the serotoninergic system in human obesity, an insulin tolerance test (ITT) was carried out on 12 obese normoprolactinemic women and on 6 normal-weight women before (A) and after (B) the administration of a serotoninergic drug, fenfluramine (60 mg twice a day per os for 7 days)."7.67Effects of fenfluramine and ritanserin on prolactin response to insulin-induced hypoglycemia in obese patients: evidence for failure of the serotoninergic system. ( Argenio, GF; Bernini, GP; Del Corso, C; Franchi, F; Luisi, M; Sgrò, M; Vivaldi, MS, 1989)
" We hypothesized that CFS is mediated by changes in hypothalamopituitary function and so measured the adrenocorticotrophic hormone (ACTH), cortisol, growth hormone, and prolactin responses to insulin-induced hypoglycemia, and the ACTH, cortisol, and prolactin responses to serotoninergic stimulation with dexfenfluramine in nondepressed CFS patients and normal controls."3.69Neuroendocrine responses to d-fenfluramine and insulin-induced hypoglycemia in chronic fatigue syndrome. ( Allain, T; Bearn, J; Butler, J; Coskeran, P; McGregor, A; Munro, N; Wessely, S, 1995)
"In order to study the hypothesized impairment of the serotoninergic system in human obesity, an insulin tolerance test (ITT) was carried out on 12 obese normoprolactinemic women and on 6 normal-weight women before (A) and after (B) the administration of a serotoninergic drug, fenfluramine (60 mg twice a day per os for 7 days)."3.67Effects of fenfluramine and ritanserin on prolactin response to insulin-induced hypoglycemia in obese patients: evidence for failure of the serotoninergic system. ( Argenio, GF; Bernini, GP; Del Corso, C; Franchi, F; Luisi, M; Sgrò, M; Vivaldi, MS, 1989)
"Ritanserin is a new selective 5-HT2 blocker receptor agent."2.67Impaired growth hormone response to insulin-induced hypoglycaemia in obese patients: restoration blocked by ritanserin after fenfluramine administration. ( Argenio, GF; Bernini, GP; Birindelli, R; Del Corso, C; Franchi, F; Luisi, M; Vivaldi, MS, 1990)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19902 (50.00)18.7374
1990's2 (50.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bearn, J1
Allain, T1
Coskeran, P1
Munro, N1
Butler, J1
McGregor, A1
Wessely, S1
Bernini, GP2
Argenio, GF2
Vivaldi, MS2
Del Corso, C2
Birindelli, R1
Luisi, M2
Franchi, F2
Sgrò, M1
Turtle, JR1
Burgess, JA1

Trials

1 trial available for fenfluramine and Fasting Hypoglycemia

ArticleYear
Impaired growth hormone response to insulin-induced hypoglycaemia in obese patients: restoration blocked by ritanserin after fenfluramine administration.
    Clinical endocrinology, 1990, Volume: 32, Issue:4

    Topics: Adult; Blood Glucose; Female; Fenfluramine; Growth Hormone; Humans; Hypoglycemia; Insulin; Middle Ag

1990

Other Studies

3 other studies available for fenfluramine and Fasting Hypoglycemia

ArticleYear
Neuroendocrine responses to d-fenfluramine and insulin-induced hypoglycemia in chronic fatigue syndrome.
    Biological psychiatry, 1995, Feb-15, Volume: 37, Issue:4

    Topics: Adrenocorticotropic Hormone; Adult; Fatigue Syndrome, Chronic; Female; Fenfluramine; Growth Hormone;

1995
Effects of fenfluramine and ritanserin on prolactin response to insulin-induced hypoglycemia in obese patients: evidence for failure of the serotoninergic system.
    Hormone research, 1989, Volume: 31, Issue:3

    Topics: Adolescent; Adult; Female; Fenfluramine; Humans; Hypoglycemia; Insulin; Middle Aged; Obesity; Piperi

1989
Hypoglycemic action of fenfluramine in diabetes mellitus.
    Diabetes, 1973, Volume: 22, Issue:11

    Topics: Adipose Tissue; Antigens; Blood Glucose; Diabetes Mellitus; Diet, Diabetic; Fatty Acids, Nonesterifi

1973