fenfluramine has been researched along with Epilepsy, Reflex in 1 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Epilepsy, Reflex: A subtype of epilepsy characterized by seizures that are consistently provoked by a certain specific stimulus. Auditory, visual, and somatosensory stimuli as well as the acts of writing, reading, eating, and decision making are examples of events or activities that may induce seizure activity in affected individuals. (From Neurol Clin 1994 Feb;12(1):57-8)
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study reports on the long-term results for an initial cohort of patients with Sunflower syndrome who enrolled in an open-label study of low-dose fenfluramine as well as the short-term results of a second cohort." | 9.69 | Follow-up to low-dose fenfluramine for Sunflower syndrome: A non-randomized controlled trial. ( Bruno, PL; Dowless, D; Geenen, KR; Patel, S; Thiele, EA, 2023) |
| "This study reports on the long-term results for an initial cohort of patients with Sunflower syndrome who enrolled in an open-label study of low-dose fenfluramine as well as the short-term results of a second cohort." | 5.69 | Follow-up to low-dose fenfluramine for Sunflower syndrome: A non-randomized controlled trial. ( Bruno, PL; Dowless, D; Geenen, KR; Patel, S; Thiele, EA, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Patel, S | 1 |
| Geenen, KR | 1 |
| Dowless, D | 1 |
| Bruno, PL | 1 |
| Thiele, EA | 1 |
1 trial available for fenfluramine and Epilepsy, Reflex
| Article | Year |
|---|---|
Follow-up to low-dose fenfluramine for Sunflower syndrome: A non-randomized controlled trial.
Topics: Anticonvulsants; Epilepsy, Reflex; Fenfluramine; Follow-Up Studies; Helianthus; Humans; Seizures; Sy | 2023 |