fenfluramine has been researched along with Endocarditis, Bacterial in 6 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Endocarditis, Bacterial: Inflammation of the ENDOCARDIUM caused by BACTERIA that entered the bloodstream. The strains of bacteria vary with predisposing factors, such as CONGENITAL HEART DEFECTS; HEART VALVE DISEASES; HEART VALVE PROSTHESIS IMPLANTATION; or intravenous drug use.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The Ministry of Health has recently alerted practitioners to the possible risk of heart valve damage following the long-term use of weight-loss drugs fenfluramine (Ponderax) and dexfenfluramine (Adifax)." | 1.30 | Prevention of infective endocarditis associated with dental treatment and other medical interventions. National Heart Foundation. ( Ellis-Pegler, RB; Hay, KD; Lang, SD; Neutze, JM; Swinburn, BA, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (83.33) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Aurigemma, GP | 1 |
| Gaasch, WH | 1 |
| Biron, CR | 1 |
| Pallasch, TJ | 1 |
| Ellis-Pegler, RB | 1 |
| Hay, KD | 1 |
| Lang, SD | 1 |
| Neutze, JM | 1 |
| Swinburn, BA | 1 |
| Rudin, R | 1 |
| Carpenter, W | 1 |
1 review available for fenfluramine and Endocarditis, Bacterial
| Article | Year |
|---|---|
Current status of fenfluramine/dexfenfluramine-induced cardiac valvulopathy.
Topics: Antibiotic Prophylaxis; Appetite Depressants; Dental Care for Chronically Ill; Dexfenfluramine; Drug | 1999 |
5 other studies available for fenfluramine and Endocarditis, Bacterial
| Article | Year |
|---|---|
Dentists should exercise caution with fen-phen users.
Topics: Anti-Bacterial Agents; Appetite Depressants; Chemoprevention; Dental Care; Endocarditis, Bacterial; | 1997 |
Valve disease and diet pills--where do we stand?
Topics: Adult; Aged; Aged, 80 and over; Appetite Depressants; Dopamine Agents; Drug Therapy, Combination; Ec | 1998 |
Former Fen-Phen users may need prophylactic antibiotic before treatment.
Topics: Antibiotic Prophylaxis; Appetite Depressants; Dental Care for Chronically Ill; Drug Combinations; En | 1998 |
Prevention of infective endocarditis associated with dental treatment and other medical interventions. National Heart Foundation.
Topics: Adult; Anti-Obesity Agents; Antibiotic Prophylaxis; Aortic Valve Insufficiency; Cefuroxime; Cephalos | 1999 |
Diet drugs and cardiac valvulopathy: a survey of dental patients.
Topics: Adult; Antibiotic Prophylaxis; Appetite Depressants; Dental Care; Dexfenfluramine; Endocarditis, Bac | 2000 |