fenfluramine has been researched along with Encephalopathy, Toxic in 5 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Drugs were subsequently tested for potential long-lasting effects on brain tissue 5-HT after repeated dosing (2." | 1.31 | Serotonin transporters, serotonin release, and the mechanism of fenfluramine neurotoxicity. ( Ayestas, MA; Baumann, MH; Dersch, CM; Partilla, JS; Rothman, RB, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (80.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lyvers, M | 1 |
| Wolkowitz, OM | 1 |
| Lupien, SJ | 1 |
| Bigler, E | 1 |
| Levin, RB | 1 |
| Canick, J | 1 |
| Achat-Mendes, C | 1 |
| Ali, SF | 1 |
| Itzhak, Y | 1 |
| Poston, WS | 1 |
| Foreyt, JP | 1 |
| Baumann, MH | 1 |
| Ayestas, MA | 1 |
| Dersch, CM | 1 |
| Partilla, JS | 1 |
| Rothman, RB | 1 |
1 review available for fenfluramine and Encephalopathy, Toxic
| Article | Year |
|---|---|
Scientific and legal issues in fenfluramine/dexfenfluramine litigation.
Topics: Anti-Obesity Agents; Dexfenfluramine; Fenfluramine; Heart Valve Diseases; Humans; Hypertension, Pulm | 2000 |
4 other studies available for fenfluramine and Encephalopathy, Toxic
| Article | Year |
|---|---|
Commentary on Halpern et al. (2011): strengthening the case against functionally significant serotonergic neurotoxicity in human MDMA (ecstasy) users.
Topics: Fenfluramine; Hallucinogens; Humans; N-Methyl-3,4-methylenedioxyamphetamine; Neurotoxicity Syndromes | 2011 |
The "steroid dementia syndrome": an unrecognized complication of glucocorticoid treatment.
Topics: Adult; Alopecia Areata; Anti-Inflammatory Agents; Appetite Depressants; Brain; Child; Dementia; Fema | 2004 |
Differential effects of amphetamines-induced neurotoxicity on appetitive and aversive Pavlovian conditioning in mice.
Topics: Amphetamines; Animals; Antimanic Agents; Appetitive Behavior; Avoidance Learning; Central Nervous Sy | 2005 |
Serotonin transporters, serotonin release, and the mechanism of fenfluramine neurotoxicity.
Topics: Analysis of Variance; Animals; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Disease | 2000 |