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fenfluramine and Embolism, Pulmonary

fenfluramine has been researched along with Embolism, Pulmonary in 2 studies

Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.

Research Excerpts

ExcerptRelevanceReference
"There has been suggestion of a possible relationship between the intake of the appetite suppressant dexfenfluramine and the development of primary pulmonary hypertension."7.69Effects of dexfenfluramine on hypoxic pulmonary vasoconstriction and embolic pulmonary hypertension in dogs. ( Delcroix, M; Leeman, M; Maggiorini, M; Naeije, R; Wauthy, P, 1995)
"There has been suggestion of a possible relationship between the intake of the appetite suppressant dexfenfluramine and the development of primary pulmonary hypertension."3.69Effects of dexfenfluramine on hypoxic pulmonary vasoconstriction and embolic pulmonary hypertension in dogs. ( Delcroix, M; Leeman, M; Maggiorini, M; Naeije, R; Wauthy, P, 1995)
"Precapillary pulmonary hypertension is defined by an increase in mPAP > or =25 mmHg and a pulmonary capillary wedge pressure (PCWP)< or =15 mmHg associated with a normal or reduced cardiac output."1.36[Diagnosis and classification of pulmonary hypertension]. ( Chaouat, A; Montani, D, 2010)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (50.00)18.2507
2000's0 (0.00)29.6817
2010's1 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Montani, D1
Chaouat, A1
Naeije, R1
Wauthy, P1
Maggiorini, M1
Leeman, M1
Delcroix, M1

Other Studies

2 other studies available for fenfluramine and Embolism, Pulmonary

ArticleYear
[Diagnosis and classification of pulmonary hypertension].
    Presse medicale (Paris, France : 1983), 2010, Volume: 39 Suppl 1

    Topics: Activin Receptors, Type II; Anemia, Hemolytic; Bone Morphogenetic Protein Receptors, Type II; Cardia

2010
Effects of dexfenfluramine on hypoxic pulmonary vasoconstriction and embolic pulmonary hypertension in dogs.
    American journal of respiratory and critical care medicine, 1995, Volume: 151, Issue:3 Pt 1

    Topics: Animals; Dogs; Fenfluramine; Hypertension, Pulmonary; Hypoxia; Ketanserin; Pulmonary Artery; Pulmona

1995