fenfluramine has been researched along with Embolism, Pulmonary in 2 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
| Excerpt | Relevance | Reference |
|---|---|---|
| "There has been suggestion of a possible relationship between the intake of the appetite suppressant dexfenfluramine and the development of primary pulmonary hypertension." | 7.69 | Effects of dexfenfluramine on hypoxic pulmonary vasoconstriction and embolic pulmonary hypertension in dogs. ( Delcroix, M; Leeman, M; Maggiorini, M; Naeije, R; Wauthy, P, 1995) |
| "There has been suggestion of a possible relationship between the intake of the appetite suppressant dexfenfluramine and the development of primary pulmonary hypertension." | 3.69 | Effects of dexfenfluramine on hypoxic pulmonary vasoconstriction and embolic pulmonary hypertension in dogs. ( Delcroix, M; Leeman, M; Maggiorini, M; Naeije, R; Wauthy, P, 1995) |
| "Precapillary pulmonary hypertension is defined by an increase in mPAP > or =25 mmHg and a pulmonary capillary wedge pressure (PCWP)< or =15 mmHg associated with a normal or reduced cardiac output." | 1.36 | [Diagnosis and classification of pulmonary hypertension]. ( Chaouat, A; Montani, D, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Montani, D | 1 |
| Chaouat, A | 1 |
| Naeije, R | 1 |
| Wauthy, P | 1 |
| Maggiorini, M | 1 |
| Leeman, M | 1 |
| Delcroix, M | 1 |
2 other studies available for fenfluramine and Embolism, Pulmonary
| Article | Year |
|---|---|
[Diagnosis and classification of pulmonary hypertension].
Topics: Activin Receptors, Type II; Anemia, Hemolytic; Bone Morphogenetic Protein Receptors, Type II; Cardia | 2010 |
Effects of dexfenfluramine on hypoxic pulmonary vasoconstriction and embolic pulmonary hypertension in dogs.
Topics: Animals; Dogs; Fenfluramine; Hypertension, Pulmonary; Hypoxia; Ketanserin; Pulmonary Artery; Pulmona | 1995 |