fenfluramine has been researched along with Dyskinesia Syndromes in 8 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Since dietary thiamine deficiency (TD) in mice is considered as a putative model of WKS, it was used in the present study to investigate the function of serotonergic neurons in this disorder." | 3.74 | Enhanced head-twitch response to 5-HT-related agonists in thiamine-deficient mice. ( Arai, Y; Mitazaki, S; Murata, A; Nakagawasai, O; Niijima, F; Ohba, A; Tadano, T; Tan-No, K; Wakui, K, 2007) |
| "Fenfluramine was intermediate in its effects on reproduction and growth and had behavioral effects that were revealed in tests of preweaning development." | 1.26 | Psychotropic drugs as behavioral teratogens. ( Brunner, RL; Butcher, RE; Vorhees, CV, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (75.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hayashi, Y | 1 |
| Jacob-Vadakot, S | 1 |
| Dugan, EA | 1 |
| McBride, S | 1 |
| Olexa, R | 1 |
| Simansky, K | 1 |
| Murray, M | 1 |
| Shumsky, JS | 1 |
| Nakagawasai, O | 1 |
| Murata, A | 1 |
| Arai, Y | 1 |
| Ohba, A | 1 |
| Wakui, K | 1 |
| Mitazaki, S | 1 |
| Niijima, F | 1 |
| Tan-No, K | 1 |
| Tadano, T | 1 |
| Broekkamp, CL | 1 |
| LePichon, M | 1 |
| Lloyd, KG | 1 |
| Vorhees, CV | 1 |
| Brunner, RL | 1 |
| Butcher, RE | 1 |
| Gerber, R | 1 |
| Barbaz, BJ | 1 |
| Martin, LL | 1 |
| Neale, R | 1 |
| Williams, M | 1 |
| Liebman, JM | 1 |
| Shoulson, I | 1 |
| Chase, TN | 1 |
| Sananman, ML | 1 |
| Brandon, S | 1 |
8 other studies available for fenfluramine and Dyskinesia Syndromes
| Article | Year |
|---|---|
5-HT precursor loading, but not 5-HT receptor agonists, increases motor function after spinal cord contusion in adult rats.
Topics: 5-Hydroxytryptophan; Animals; Carbidopa; Cervical Vertebrae; Disease Models, Animal; Dose-Response R | 2010 |
Enhanced head-twitch response to 5-HT-related agonists in thiamine-deficient mice.
Topics: Amphetamines; Animals; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Toleran | 2007 |
Akinesia after locally applied morphine near the nucleus raphe pontis of the rat.
Topics: Animals; Brain Mapping; Drug Synergism; Fenfluramine; Morphine; Movement Disorders; Pons; Raphe Nucl | 1984 |
Psychotropic drugs as behavioral teratogens.
Topics: Animals; Behavior, Animal; Brain Chemistry; Dextropropoxyphene; Disease Models, Animal; Female; Fenf | 1979 |
Antagonism of L-5-hydroxytryptophan-induced head twitching in rats by lisuride: a mixed 5-hydroxytryptamine agonist-antagonist?
Topics: 5-Hydroxytryptophan; Animals; Dopamine; Ergolines; Fenfluramine; Lisuride; Lysergic Acid Diethylamid | 1985 |
Letter: Fenfluramine and dyskinesias.
Topics: Chemoreceptor Cells; Dopamine; Fenfluramine; Humans; Movement Disorders; Serotonin; Stimulation, Che | 1974 |
Letter: Dyskinesia after fenfluramine.
Topics: Adult; Diphenhydramine; Female; Fenfluramine; Humans; Injections, Intravenous; Movement Disorders; T | 1974 |
Unusual effect of fenfluramine.
Topics: Adolescent; Appetite Depressants; Cognition Disorders; Drug Synergism; Female; Fenfluramine; Fluorin | 1969 |