fenfluramine has been researched along with Drug Overdose in 4 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Drug Overdose: Accidental or deliberate use of a medication or street drug in excess of normal dosage.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fenfluramine was detected in the blood sample collected from the victim at the concentration of 7." | 1.31 | Simple and simultaneous analysis of fenfluramine, amphetamine and methamphetamine in whole blood by gas chromatography-mass spectrometry after headspace-solid phase microextraction and derivatization. ( Hara, K; Imamura, T; Kojima, T; Liu, J; Namera, A; Okajima, K; Yashiki, M, 2000) |
| " Chronic use of fenfluramine was clearly demonstrated by the presence of drug in hair at 14." | 1.28 | Toxicological findings after fatal fenfluramine self-poisoning. ( Kintz, P; Mangin, P, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (75.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Genné, D | 1 |
| De Torrenté, A | 1 |
| Humair, L | 1 |
| Koury, R | 1 |
| Stone, CK | 1 |
| Stapczynski, JS | 1 |
| Blake, J | 1 |
| Namera, A | 1 |
| Yashiki, M | 1 |
| Liu, J | 1 |
| Okajima, K | 1 |
| Hara, K | 1 |
| Imamura, T | 1 |
| Kojima, T | 1 |
| Kintz, P | 1 |
| Mangin, P | 1 |
4 other studies available for fenfluramine and Drug Overdose
| Article | Year |
|---|---|
[Voluntary poisoning with dexfenfluramine (Isomeride)].
Topics: Adolescent; Drug Overdose; Female; Fenfluramine; Humans; Hypertension; Iatrogenic Disease; Poisoning | 1994 |
Sympathetic overactivity from fenfluramine-phentermine overdose.
Topics: Adrenergic Antagonists; Adult; Appetite Depressants; Burns; Drug Combinations; Drug Overdose; Fenflu | 1999 |
Simple and simultaneous analysis of fenfluramine, amphetamine and methamphetamine in whole blood by gas chromatography-mass spectrometry after headspace-solid phase microextraction and derivatization.
Topics: Adult; Amphetamine; Appetite Depressants; Calibration; Central Nervous System Stimulants; Chemical P | 2000 |
Toxicological findings after fatal fenfluramine self-poisoning.
Topics: Adult; Chromatography, Gas; Drug Overdose; Female; Fenfluramine; Humans | 1992 |