fenfluramine has been researched along with Disruptive, Impulse Control, and Conduct Disorders in 4 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Disruptive, Impulse Control, and Conduct Disorders: Disorders whose essential features are the failure to resist an impulse, drive, or temptation to perform an act that is harmful to the individual or to others. Individuals experience an increased sense of tension prior to the act and pleasure, gratification or release of tension at the time of committing the act.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The role of serotonin in human aggression was evaluated by administering D-fenfluramine and comparing the effects on laboratory measures of aggression, escape and impulsivity among subjects with and without a history of conduct disorder." | 9.09 | Acute effects of D-fenfluramine on simultaneous measures of aggressive escape and impulsive responses of adult males with and without a history of conduct disorder. ( Cherek, DR; Lane, SD, 2001) |
| "Behavioral impulsivity in borderline personality disorder (BPD) is associated with indices of diminished central serotonergic function, independent of suicidal behavior, depression or alcohol use disorder." | 5.32 | Impulsivity, gender, and response to fenfluramine challenge in borderline personality disorder. ( Kelly, TM; Malone, KM; Mann, JJ; Soloff, PH; Strotmeyer, SJ, 2003) |
| "The role of serotonin in human aggression was evaluated by administering D-fenfluramine and comparing the effects on laboratory measures of aggression, escape and impulsivity among subjects with and without a history of conduct disorder." | 5.09 | Acute effects of D-fenfluramine on simultaneous measures of aggressive escape and impulsive responses of adult males with and without a history of conduct disorder. ( Cherek, DR; Lane, SD, 2001) |
| "Behavioral impulsivity in borderline personality disorder (BPD) is associated with indices of diminished central serotonergic function, independent of suicidal behavior, depression or alcohol use disorder." | 1.32 | Impulsivity, gender, and response to fenfluramine challenge in borderline personality disorder. ( Kelly, TM; Malone, KM; Mann, JJ; Soloff, PH; Strotmeyer, SJ, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Coccaro, EF | 1 |
| Lee, R | 1 |
| Kavoussi, RJ | 1 |
| Soloff, PH | 1 |
| Kelly, TM | 1 |
| Strotmeyer, SJ | 1 |
| Malone, KM | 1 |
| Mann, JJ | 1 |
| Herpertz, S | 1 |
| Steinmeyer, SM | 1 |
| Marx, D | 1 |
| Oidtmann, A | 1 |
| Sass, H | 1 |
| Cherek, DR | 1 |
| Lane, SD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Pimavanserin on Aggression and Social Cognition.[NCT05895513] | Phase 2 | 35 participants (Anticipated) | Interventional | 2024-01-31 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for fenfluramine and Disruptive, Impulse Control, and Conduct Disorders
| Article | Year |
|---|---|
Aggression, suicidality, and intermittent explosive disorder: serotonergic correlates in personality disorder and healthy control subjects.
Topics: Adult; Aggression; Analysis of Variance; Disruptive, Impulse Control, and Conduct Disorders; Female; | 2010 |
The significance of aggression and impulsivity for self-mutilative behavior.
Topics: Adult; Aggression; Biomarkers; Depression; Disruptive, Impulse Control, and Conduct Disorders; Femal | 1995 |
Acute effects of D-fenfluramine on simultaneous measures of aggressive escape and impulsive responses of adult males with and without a history of conduct disorder.
Topics: Adult; Aggression; Conduct Disorder; Disruptive, Impulse Control, and Conduct Disorders; Electrocard | 2001 |
1 other study available for fenfluramine and Disruptive, Impulse Control, and Conduct Disorders
| Article | Year |
|---|---|
Impulsivity, gender, and response to fenfluramine challenge in borderline personality disorder.
Topics: Adult; Aggression; Body Mass Index; Borderline Personality Disorder; Diagnostic and Statistical Manu | 2003 |