fenfluramine has been researched along with Diseases, Metabolic in 4 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Benfluorex was well tolerated by all patients and no adverse event was reported." | 2.66 | Effects of benfluorex in obese patients with metabolic disorders. ( di Martino, G; Federico, P; Jacono, G; Mattera, E, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tramoni, M | 1 |
| Glikmanas, M | 2 |
| di Martino, G | 1 |
| Federico, P | 1 |
| Mattera, E | 1 |
| Jacono, G | 1 |
| Rini, GB | 1 |
| Di Fede, G | 1 |
| Renda, G | 1 |
1 trial available for fenfluramine and Diseases, Metabolic
| Article | Year |
|---|---|
Effects of benfluorex in obese patients with metabolic disorders.
Topics: Blood Glucose; Female; Fenfluramine; Hormones; Humans; Hypolipidemic Agents; Lipids; Male; Metabolic | 1989 |
3 other studies available for fenfluramine and Diseases, Metabolic
| Article | Year |
|---|---|
[Value of benfluorex in the treatment of metabolic disorders associated with diabetes].
Topics: Diabetes Complications; Fenfluramine; Humans; Metabolic Diseases | 1981 |
[Efficacy of benfluorex in the treatment of multiple metabolic overloads: preliminary results concerning 1609 cases].
Topics: Body Weight; Carbohydrate Metabolism; Fenfluramine; Humans; Hypolipidemic Agents; Lipid Metabolism; | 1980 |
Possibilities for the management of multiple metabolic disorders with benfluorex.
Topics: Adult; Appetite Depressants; Fenfluramine; Humans; Male; Metabolic Diseases; Middle Aged | 1987 |