fenfluramine has been researched along with Disease Exacerbation in 6 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Goldberg, E | 1 |
| Grau, JB | 1 |
| Fortier, JH | 1 |
| Salvati, E | 1 |
| Levy, RJ | 1 |
| Ferrari, G | 1 |
| Wee, CC | 1 |
| Phillips, RS | 1 |
| Aurigemma, G | 1 |
| Erban, S | 1 |
| Kriegel, G | 1 |
| Riley, M | 1 |
| Douglas, PS | 1 |
| Prasad, A | 1 |
| Mehra, M | 1 |
| Park, M | 1 |
| Scott, R | 1 |
| Uber, PA | 1 |
| McFadden, PM | 1 |
| St John Sutton, M | 1 |
| Mast, ST | 1 |
| Jollis, JG | 1 |
| Ryan, T | 1 |
| Anstrom, KJ | 1 |
| Crary, JL | 1 |
| Dahl, CF | 1 |
| Allen, MR | 1 |
6 other studies available for fenfluramine and Disease Exacerbation
| Article | Year |
|---|---|
Serotonin and catecholamines in the development and progression of heart valve diseases.
Topics: Animals; Catecholamines; Disease Progression; Fenfluramine; Heart Valve Diseases; Humans; Neurotrans | 2017 |
Risk for valvular heart disease among users of fenfluramine and dexfenfluramine who underwent echocardiography before use of medication.
Topics: Adult; Appetite Depressants; Cohort Studies; Dexfenfluramine; Disease Progression; Echocardiography; | 1998 |
Cardiac allograft valvulopathy: a case of donor-anorexigen-induced valvular disease.
Topics: Adult; Appetite Depressants; Disease Progression; Echocardiography; Echocardiography, Doppler; Femal | 1999 |
Silver lining to the cloud over anorexogen-related cardiac valvulopathy?
Topics: Aortic Valve Insufficiency; Appetite Depressants; Disease Progression; Fenfluramine; Humans; Mitral | 2001 |
The progression of fenfluramine-associated valvular heart disease assessed by echocardiography.
Topics: Adult; Aortic Valve Insufficiency; Appetite Depressants; Cohort Studies; Dexfenfluramine; Disease Pr | 2001 |
Regression and progression of valvulopathy associated with fenfluramine and phentermine.
Topics: Aortic Valve Insufficiency; Appetite Depressants; Disease Progression; Drug Therapy, Combination; Ec | 2002 |