fenfluramine has been researched along with Diathesis in 3 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Dexfenfluramine and fenfluramine greatly increase the risk of developing pulmonary hypertension (PHT)." | 7.70 | Nitric oxide deficiency in fenfluramine- and dexfenfluramine-induced pulmonary hypertension. ( Archer, SL; Dall'ava-Santucci, J; Dinh-Xuan, AT; Djaballah, K; Fartoukh, M; Humbert, M; Mercier, JC; Simonneau, G; Weir, KE, 1998) |
| "Dexfenfluramine and fenfluramine greatly increase the risk of developing pulmonary hypertension (PHT)." | 3.70 | Nitric oxide deficiency in fenfluramine- and dexfenfluramine-induced pulmonary hypertension. ( Archer, SL; Dall'ava-Santucci, J; Dinh-Xuan, AT; Djaballah, K; Fartoukh, M; Humbert, M; Mercier, JC; Simonneau, G; Weir, KE, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sher, L | 1 |
| Oquendo, MA | 1 |
| Li, S | 1 |
| Ellis, S | 1 |
| Brodsky, BS | 1 |
| Malone, KM | 1 |
| Cooper, TB | 1 |
| Mann, JJ | 1 |
| Marks, DJ | 1 |
| Miller, SR | 1 |
| Schulz, KP | 1 |
| Newcorn, JH | 1 |
| Halperin, JM | 1 |
| Archer, SL | 1 |
| Djaballah, K | 1 |
| Humbert, M | 1 |
| Weir, KE | 1 |
| Fartoukh, M | 1 |
| Dall'ava-Santucci, J | 1 |
| Mercier, JC | 1 |
| Simonneau, G | 1 |
| Dinh-Xuan, AT | 1 |
1 trial available for fenfluramine and Diathesis
| Article | Year |
|---|---|
Prolactin response to fenfluramine administration in patients with unipolar and bipolar depression and healthy controls.
Topics: Adult; Age Distribution; Bipolar Disorder; Depressive Disorder, Major; Disease Susceptibility; Femal | 2003 |
2 other studies available for fenfluramine and Diathesis
| Article | Year |
|---|---|
The interaction of psychosocial adversity and biological risk in childhood aggression.
Topics: Aggression; Antisocial Personality Disorder; Attention Deficit and Disruptive Behavior Disorders; Ch | 2007 |
Nitric oxide deficiency in fenfluramine- and dexfenfluramine-induced pulmonary hypertension.
Topics: Adult; Aged; Angina Pectoris; Appetite Depressants; Case-Control Studies; Dexfenfluramine; Disease S | 1998 |