fenfluramine has been researched along with Diarrhea in 11 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Diarrhea: An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sian, MS | 1 |
| Rains, AJ | 1 |
| Stunkard, A | 1 |
| Rickels, K | 1 |
| Hesbacher, P | 1 |
| Opitz, K | 1 |
| Abdel-Kader, MM | 1 |
| Mashaly, M | 1 |
| Abdel-Aziz, MT | 1 |
| Lele, RD | 1 |
| Joshi, VR | 1 |
| Nathwani, AN | 1 |
| Greenwood, MH | 1 |
| Haug, E | 1 |
| Myklebust, R | 1 |
| Jervell, J | 1 |
| Gaind, R | 1 |
| Munro, JF | 1 |
| Seaton, DA | 1 |
| Duncan, LJ | 1 |
1 review available for fenfluramine and Diarrhea
| Article | Year |
|---|---|
[Side effects associated with prolonged use of fenfluramine].
Topics: Depersonalization; Diarrhea; Fatigue; Fenfluramine; Humans; Libido; Sleep; Substance-Related Disorde | 1973 |
5 trials available for fenfluramine and Diarrhea
| Article | Year |
|---|---|
Fenfluramine in the treatment of obesity.
Topics: Adult; Appetite Depressants; Body Weight; Clinical Trials as Topic; Constipation; Dextroamphetamine; | 1973 |
A double-blind clinical trial of fenfluramine.
Topics: Appetite Regulation; Blood Pressure; Body Height; Body Weight; Clinical Trials as Topic; Diarrhea; F | 1972 |
[The therapeutic effect of Fenfluramine on body weight in overweight patients. A controlled clinical study].
Topics: Adolescent; Adult; Blood Pressure; Clinical Trials as Topic; Constipation; Depression, Chemical; Dia | 1973 |
Fenfluramine (Ponderax) in the treatment of obese psychiatric out-patients.
Topics: Anxiety Disorders; Appetite Depressants; Body Weight; Clinical Trials as Topic; Depression; Diarrhea | 1969 |
Treatment of refractory obesity with fenfluramine.
Topics: Adult; Aged; Appetite Depressants; Clinical Trials as Topic; Diarrhea; Female; Fenfluramine; Humans; | 1966 |
5 other studies available for fenfluramine and Diarrhea
| Article | Year |
|---|---|
Bile acid, neutral sterol and faecal fat excretion in subjects treated with fenfluramine and its relationship to fenfluramine-induced diarrhoea.
Topics: Bile Acids and Salts; Body Weight; Diarrhea; Feces; Fenfluramine; Humans; Lipid Metabolism; Sterols | 1979 |
[Anorexigenic phenylalkylamines and serotonin metabolism].
Topics: 5-Hydroxytryptophan; Animals; Appetite Depressants; Chlorphentermine; Diarrhea; Eating; Feeding and | 1967 |
Clinical and biochemical studies on obese subjects using fenfluramine.
Topics: Anorexia Nervosa; Blood Pressure; Diarrhea; Fatigue; Female; Fenfluramine; Glucose Tolerance Test; H | 1974 |
No. 7 fenfluramine "Ponderax".
Topics: Administration, Oral; Amphetamine; Diarrhea; Diet, Reducing; Fenfluramine; Obesity | 1972 |
[Drug therapy of obesity].
Topics: Diarrhea; Fatigue; Fenfluramine; Humans; Obesity | 1973 |