fenfluramine has been researched along with Depressive Disorder in 85 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Depressive Disorder: An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Patients suffering from major depression in the post-stroke period have a blunted prolactin response to D-fenfluramine." | 9.10 | Blunted prolactin response to D-fenfluramine in post-stroke major depression. ( Hopwood, M; Maguire, K; Morris, P; Norman, T; Schweitzer, I, 2003) |
| "A double-blind, placebo-controlled trial of d-fenfluramine in bulimia nervosa was undertaken in order to assess its efficacy in controlling bulimic behavior and relieving more general symptoms." | 9.06 | A controlled trial of d-fenfluramine in bulimia nervosa. ( Checkley, SA; Eisler, I; Feldman, J; Russell, GF, 1988) |
| "We describe the use of dexfenfluramine (Redux) in six patients with mood disorders (bipolar disorder = 3; major depression = 3) who developed significant weight gain as a result of their psychotropics." | 7.69 | Dexfenfluramine for weight gain secondary to psychotropics. ( Gupta, S; Masand, PS, 1997) |
| "Cortisol and prolactin responses to d-fenfluramine were measured in 10 drug-free normothymic patients with obsessive-compulsive disorder (OCD)." | 7.68 | Cortisol and prolactin responses to d-fenfluramine in non-depressed patients with obsessive-compulsive disorder: a comparison with depressed and healthy controls. ( Butcher, G; Clare, AW; Dinan, TG; Lucey, JV; O'Keane, V, 1992) |
| "Adinazolam treatment did not alter the platelet shape change response." | 6.67 | Downregulation of serotonin receptor subtypes by nortriptyline and adinazolam in major depressive disorder: neuroendocrine and platelet markers. ( Fleishaker, JC; Hauger, RL; Hubbell-Alberts, E; Rausch, JL; Stahl, SM, 1993) |
| "Hypothyroidism is associated with both reduced central 5-HT function and an increased incidence of depression." | 5.29 | Thyroxine replacement increases central 5-hydroxytryptamine activity and reduces depressive symptoms in hypothyroidism. ( Chambers, SM; Cleare, AJ; Dawling, S; McGregor, A; O'Keane, V, 1996) |
| "Patients suffering from major depression in the post-stroke period have a blunted prolactin response to D-fenfluramine." | 5.10 | Blunted prolactin response to D-fenfluramine in post-stroke major depression. ( Hopwood, M; Maguire, K; Morris, P; Norman, T; Schweitzer, I, 2003) |
| "The authors studied 19 outpatients with major depressive disorder using prolactin response to d-fenfluramine as a measure of central serotonergic functioning." | 5.09 | Prolactin response to d-fenfluramine in major depression before and after treatment with serotonin reuptake inhibitors. ( Coccaro, EF; Hauger, RL; Kavoussi, RJ, 1999) |
| " Under randomized double-blind conditions, prolactin and cortisol responses to the serotonin-releasing agent d,l-fenfluramine hydrochloride (60 mg orally) and placebo were examined in 30 normal subjects (15 men, 15 women; age range 21-84 years) and 39 patients with major depressive disorder, endogenous subtype (14 men, 25 women; age range 29-72 years)." | 5.08 | Interrelationship of age, depression, and central serotonergic function: evidence from fenfluramine challenge studies. ( Gelfin, Y; Gillon, D; Gorfine, M; Lerer, B; Lichtenberg, P; Shapira, B, 1996) |
| "Prolactin (PRL) and cortisol responses to oral administration of d-1 fenfluramine hydrochloride (60 mg) and placebo were examined in patients with endogenous major depressive disorder on three separate occasions: prior to treatment with clomipramine (CMI), after 4 weeks of CMI administration (175-250) mg/day), and 3 weeks after addition of lithium (Li) carbonate (serum level 0." | 5.07 | Effect of clomipramine and lithium on fenfluramine-induced hormone release in major depression. ( Gropp, C; Lerer, B; Newman, M; Shapira, B; Yagmur, MJ, 1992) |
| "Fenfluramine, and indirect serotonergic agonist, was administered to nine women with panic disorder, nine women with major depressive disorder, and nine women controls." | 5.06 | Fenfluramine provocation of anxiety in patients with panic disorder. ( Marshall, LE; Targum, SD, 1989) |
| "We examined the utility of d-fenfluramine, a serotonin-releasing drug previously shown to diminish carbohydrate craving and weight gain in obese people, in treating patients with seasonal affective disorder (SAD), a variant of depression that occurs each fall and winter and is usually associated with hyperphagia and carbohydrate craving." | 5.06 | Nutrient imbalances in depressive disorders. Possible brain mechanisms. ( O'Rourke, D; Wurtman, JJ; Wurtman, RJ, 1989) |
| "Patients with chronic low-back pain and depression were treated double blind with desipramine or doxepin." | 5.06 | Tricyclic antidepressants for chronic low-back pain. Mechanisms of action and predictors of response. ( Ward, NG, 1986) |
| "A double-blind, placebo-controlled trial of d-fenfluramine in bulimia nervosa was undertaken in order to assess its efficacy in controlling bulimic behavior and relieving more general symptoms." | 5.06 | A controlled trial of d-fenfluramine in bulimia nervosa. ( Checkley, SA; Eisler, I; Feldman, J; Russell, GF, 1988) |
| " In order to test the serotonin hypothesis of depression, the authors compared 20 outpatients with major depressive disorder to 20 normal control subjects using prolactin response to D-fenfluramine as a measure of central serotonergic (5-HT) functioning." | 3.70 | Prolactin response to D-fenfluramine in outpatients with major depression. ( Coccaro, EF; Hauger, RL; Kavoussi, RJ; Kramer, J, 1998) |
| "We describe the use of dexfenfluramine (Redux) in six patients with mood disorders (bipolar disorder = 3; major depression = 3) who developed significant weight gain as a result of their psychotropics." | 3.69 | Dexfenfluramine for weight gain secondary to psychotropics. ( Gupta, S; Masand, PS, 1997) |
| "Cortisol and prolactin responses to d-fenfluramine were measured in 10 drug-free normothymic patients with obsessive-compulsive disorder (OCD)." | 3.68 | Cortisol and prolactin responses to d-fenfluramine in non-depressed patients with obsessive-compulsive disorder: a comparison with depressed and healthy controls. ( Butcher, G; Clare, AW; Dinan, TG; Lucey, JV; O'Keane, V, 1992) |
| "Prolactin release in response to fenfluramine hydrochloride (60 mg orally) and placebo was evaluated in 18 medication-free patients with RDC major depressive disorder, endogenous subtype, before and after a series of bilateral treatments with ECT." | 3.68 | Enhanced serotonergic responsivity following electroconvulsive therapy in patients with major depression. ( Calev, A; Cooper, T; Gropp, C; Kindler, S; Lerer, B; Lichtenberg, P; Shapira, B, 1992) |
| "Anxiogenic challenge studies (intravenous lactate infusion and oral fenfluramine challenge) were conducted in 17 patients with panic disorder (PD), 12 patients with major depressive disorder and a history of panic attacks (MDD-PD), 27 patients with major depression and no history of panic (MDD), and 12 normal controls." | 3.68 | Differential responses to anxiogenic challenge studies in patients with major depressive disorder and panic disorder. ( Targum, SD, 1990) |
| "Treatment with paroxetine significantly increased the baseline prolactin level independently of treatment response but positively correlated with paroxetine dose." | 2.70 | Prolactin response to dl-fenfluramine challenge before and after treatment with paroxetine. ( Dulchin, MC; Ellis, SP; Li, S; Malone, KM; Mann, JJ; Oquendo, MA, 2001) |
| "Adinazolam treatment did not alter the platelet shape change response." | 2.67 | Downregulation of serotonin receptor subtypes by nortriptyline and adinazolam in major depressive disorder: neuroendocrine and platelet markers. ( Fleishaker, JC; Hauger, RL; Hubbell-Alberts, E; Rausch, JL; Stahl, SM, 1993) |
| " The apparently complex influence of weight loss on prolactin response to serotonergic challenge remains to be clarified as well as the role played by the bioavailability of the challenge drug and its metabolite." | 2.67 | Hormone responses to fenfluramine and placebo challenge in endogenous depression. ( Cooper, TB; Gillon, D; Kindler, S; Lerer, B; Lichtenberg, P; Newman, ME; Shapira, B, 1992) |
| "Fenfluramine 40-120 mg/day was then added to the ongoing desipramine in a placebo substitution design." | 2.67 | Fenfluramine augmentation in tricyclic-refractory depression. ( Charney, DS; Delgado, PL; Heninger, GR; Price, LH, 1990) |
| "Hypothyroidism is associated with both reduced central 5-HT function and an increased incidence of depression." | 1.29 | Thyroxine replacement increases central 5-hydroxytryptamine activity and reduces depressive symptoms in hypothyroidism. ( Chambers, SM; Cleare, AJ; Dawling, S; McGregor, A; O'Keane, V, 1996) |
| " The findings suggest that clonidine at a dosage of 1." | 1.28 | Growth hormone and other hormonal responses to clonidine in melancholic and nonmelancholic depressed subjects and controls. ( Boyce, P; Brodaty, H; Hickie, I; Mitchell, P; Parker, G; Smythe, G; Wilhelm, K, 1991) |
| "Patients with endogenous depression (melancholia) as defined by each of ICD-9, DSM-III, RDC and Newcastle scale demonstrated a reduced prolactin response to 60 mg oral fenfluramine when compared with non-endogenous subjects." | 1.28 | Hormonal responses to fenfluramine in depressive subtypes. ( Boyce, P; Brodaty, H; Hickie, I; Mitchell, P; Parker, G; Smythe, G; Wilhelm, K, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (22.35) | 18.7374 |
| 1990's | 57 (67.06) | 18.2507 |
| 2000's | 8 (9.41) | 29.6817 |
| 2010's | 1 (1.18) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ayala, ME | 1 |
| Lanctôt, KL | 1 |
| Herrmann, N | 1 |
| Eryavec, G | 1 |
| van Reekum, R | 1 |
| Reed, K | 1 |
| Naranjo, CA | 1 |
| Oquendo, MA | 4 |
| Placidi, GP | 1 |
| Malone, KM | 7 |
| Campbell, C | 1 |
| Keilp, J | 1 |
| Brodsky, B | 1 |
| Kegeles, LS | 1 |
| Cooper, TB | 10 |
| Parsey, RV | 1 |
| van Heertum, RL | 1 |
| Mann, JJ | 12 |
| Waternaux, C | 1 |
| Haas, GL | 1 |
| Li, S | 3 |
| Morris, P | 1 |
| Hopwood, M | 1 |
| Maguire, K | 1 |
| Norman, T | 1 |
| Schweitzer, I | 1 |
| Sher, L | 1 |
| Galfalvy, HC | 1 |
| Keilp, JG | 1 |
| Stanley, BH | 1 |
| Burke, AK | 1 |
| Lechin, F | 1 |
| Van der Dijs, B | 1 |
| Gómez, F | 1 |
| Arocha, L | 1 |
| Acosta, E | 1 |
| Lechin, E | 1 |
| Siever, LJ | 4 |
| Uhde, TW | 1 |
| Jimerson, DC | 1 |
| Kafka, MS | 1 |
| Lake, CR | 1 |
| Targum, S | 1 |
| Murphy, DL | 3 |
| Silverstone, T | 1 |
| Slater, S | 1 |
| de la Vega, E | 1 |
| Lipper, S | 1 |
| Thase, ME | 2 |
| Mieczkowski, T | 3 |
| Myers, JE | 4 |
| Stull, SD | 1 |
| Williamson, DJ | 4 |
| McTavish, SF | 2 |
| Park, SB | 3 |
| Cowen, PJ | 4 |
| Thakore, JH | 1 |
| Dinan, TG | 4 |
| Toornvliet, AC | 1 |
| Pijl, H | 1 |
| Meinders, AE | 1 |
| Thompson, PA | 1 |
| Maes, M | 3 |
| Meltzer, HY | 1 |
| Stahl, SM | 2 |
| Hauger, RL | 3 |
| Rausch, JL | 1 |
| Fleishaker, JC | 1 |
| Hubbell-Alberts, E | 1 |
| Solyom, L | 1 |
| Perel, J | 3 |
| Abbondanza, D | 1 |
| Buysse, DJ | 1 |
| Miewald, JM | 1 |
| Kupfer, DJ | 1 |
| Shapira, B | 7 |
| Cohen, J | 1 |
| Newman, ME | 2 |
| Lerer, B | 7 |
| Cleare, AJ | 6 |
| Bearn, J | 1 |
| Allain, T | 1 |
| McGregor, A | 2 |
| Wessely, S | 1 |
| Murray, RM | 5 |
| O'Keane, V | 10 |
| Diehl, DJ | 1 |
| Mintun, MA | 1 |
| Gerra, G | 1 |
| Fertonani, G | 1 |
| Tagliavini, P | 1 |
| Zaimovic, A | 1 |
| Delsignore, R | 1 |
| Maestri, D | 1 |
| Avanzini, P | 1 |
| Caccavari, R | 1 |
| Brambilla, F | 1 |
| Abel, KM | 2 |
| Gillon, D | 2 |
| Lichtenberg, P | 4 |
| Gorfine, M | 1 |
| Gelfin, Y | 1 |
| Chambers, SM | 1 |
| Dawling, S | 1 |
| Corbitt, EM | 1 |
| Schenck, CH | 1 |
| Mahowald, MW | 1 |
| Kostić, VS | 1 |
| Lecić, D | 1 |
| Doder, M | 1 |
| Marinković, J | 1 |
| Filipović, S | 1 |
| Brown, GM | 2 |
| Raison, CL | 1 |
| Klein, HM | 1 |
| Mokrani, MC | 1 |
| Duval, F | 1 |
| Crocq, MA | 1 |
| Bailey, P | 1 |
| Macher, JP | 1 |
| Masand, PS | 1 |
| Gupta, S | 1 |
| Mannel, M | 1 |
| Müller-Oerlinghausen, B | 2 |
| Czernik, A | 1 |
| Sauer, H | 1 |
| Flory, JD | 1 |
| Manuck, SB | 1 |
| Muldoon, MF | 1 |
| Wadman, M | 1 |
| Kavoussi, RJ | 2 |
| Kramer, J | 1 |
| Coccaro, EF | 5 |
| Meyer, JH | 1 |
| Kennedy, S | 1 |
| Baumann, MH | 1 |
| Rothman, RB | 1 |
| Sarchiapone, M | 1 |
| Camardese, G | 1 |
| Roy, A | 1 |
| Della Casa, S | 1 |
| Satta, MA | 1 |
| Gonzalez, B | 1 |
| Berman, J | 1 |
| De Risio, S | 1 |
| Dulchin, MC | 1 |
| Ellis, SP | 1 |
| McBride, PA | 1 |
| Brown, RP | 1 |
| Linnoila, M | 1 |
| Leon, AC | 1 |
| DeMeo, M | 1 |
| Stanley, M | 1 |
| Lucey, JV | 1 |
| Butcher, G | 1 |
| Clare, AW | 1 |
| Kindler, S | 2 |
| McLoughlin, D | 1 |
| Newman, M | 2 |
| Yagmur, MJ | 1 |
| Gropp, C | 3 |
| Cooper, T | 1 |
| Calev, A | 2 |
| Blacker, M | 1 |
| Mitchell, PB | 1 |
| Smythe, GA | 1 |
| Mitchell, P | 3 |
| Smythe, G | 3 |
| Parker, G | 2 |
| Wilhelm, K | 2 |
| Brodaty, H | 2 |
| Boyce, P | 2 |
| Hickie, I | 2 |
| D'Hondt, P | 1 |
| Suy, E | 2 |
| Minner, B | 2 |
| Vandervorst, C | 1 |
| Raus, J | 2 |
| Harvey, PD | 1 |
| Kupsaw-Lawrence, E | 1 |
| Herbert, JL | 1 |
| Bernstein, DP | 1 |
| Price, LH | 1 |
| Charney, DS | 1 |
| Delgado, PL | 1 |
| Heninger, GR | 1 |
| Targum, SD | 3 |
| Kasper, S | 2 |
| Vieira, A | 2 |
| Schmidt, R | 2 |
| Richter, P | 1 |
| Jacobs, MP | 1 |
| López-Ibor, JJ | 1 |
| Saiz-Ruiz, J | 1 |
| Moral Iglesias, L | 1 |
| Marshall, LE | 1 |
| O'Rourke, D | 2 |
| Wurtman, JJ | 2 |
| Wurtman, RJ | 2 |
| Chebli, R | 1 |
| Gleason, R | 1 |
| Klar, HM | 1 |
| Maurer, G | 1 |
| Cochrane, K | 1 |
| Mohs, RC | 1 |
| Davis, KL | 2 |
| Ward, NG | 2 |
| Weizman, A | 1 |
| Mark, M | 1 |
| Gil-Ad, I | 1 |
| Tyano, S | 1 |
| Laron, Z | 1 |
| Mühlbauer, HD | 1 |
| Russell, GF | 1 |
| Checkley, SA | 1 |
| Feldman, J | 1 |
| Eisler, I | 1 |
| Pope, HG | 1 |
| Hudson, JI | 1 |
| Wehr, TA | 1 |
| Kick, H | 1 |
| Voll, G | 1 |
| Asnis, GM | 1 |
| Eisenberg, J | 1 |
| van Praag, HM | 1 |
| Lemus, CZ | 1 |
| Friedman, JM | 1 |
| Miller, AH | 1 |
| Klar, H | 1 |
| Rubenstein, K | 1 |
| Benjamin, E | 1 |
| Ang, J | 1 |
| Pavinich, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Pimavanserin on Aggression and Social Cognition.[NCT05895513] | Phase 2 | 35 participants (Anticipated) | Interventional | 2024-01-31 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for fenfluramine and Depressive Disorder
| Article | Year |
|---|---|
The clinical pharmacology of appetite--its relevance to psychiatry.
Topics: Amphetamine; Anorexia; Appetite; Bipolar Disorder; Brain Chemistry; Depressive Disorder; Dopamine; F | 1983 |
Antidepressant drug therapy for bulimia: current status.
Topics: Antidepressive Agents; Bupropion; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method | 1986 |
30 trials available for fenfluramine and Depressive Disorder
| Article | Year |
|---|---|
Blunted prolactin response to D-fenfluramine in post-stroke major depression.
Topics: Aged; Depressive Disorder; Female; Fenfluramine; Humans; Magnetic Resonance Imaging; Male; Middle Ag | 2003 |
Future suicide attempt and responses to serotonergic challenge.
Topics: Adult; Affect; Age Factors; Area Under Curve; Depressive Disorder; Fatigue; Female; Fenfluramine; Fo | 2010 |
Effect of valine on 5-HT-mediated prolactin release in healthy volunteers, and on mood in remitted depressed patients.
Topics: Adult; Affect; Aged; Amino Acids, Branched-Chain; Amitriptyline; Antidepressive Agents; Blood-Brain | 1995 |
Effect of the placebo control condition in neuroendocrine challenge studies.
Topics: 5-Hydroxytryptophan; Antipsychotic Agents; Apomorphine; Bias; Buspirone; Data Interpretation, Statis | 1994 |
Downregulation of serotonin receptor subtypes by nortriptyline and adinazolam in major depressive disorder: neuroendocrine and platelet markers.
Topics: Anti-Anxiety Agents; Antidepressive Agents; Benzodiazepines; Biomarkers; Blood Platelets; Body Tempe | 1993 |
Prolactin response to fenfluramine and placebo challenge following maintenance pharmacotherapy withdrawal in remitted depressed patients.
Topics: Clomipramine; Depressive Disorder; Drug Therapy, Combination; Female; Fenfluramine; Follow-Up Studie | 1993 |
Reduced prolactin and cortisol responses to d-fenfluramine in depressed compared to healthy matched control subjects.
Topics: Adult; Depressive Disorder; Female; Fenfluramine; Humans; Hydrocortisone; Male; Middle Aged; Prolact | 1996 |
Do the endocrine and subjective effects of d-fenfluramine predict response to selective serotonin reuptake inhibitors?
Topics: Adolescent; Adult; Depressive Disorder; Double-Blind Method; Female; Fenfluramine; Humans; Male; Mid | 1995 |
Interrelationship of age, depression, and central serotonergic function: evidence from fenfluramine challenge studies.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Brain; Depressive Disorder; Double-Blind Method; Female | 1996 |
5-HT neuroendocrine function in major depression: prolactin and cortisol responses to D-fenfluramine.
Topics: Adult; Analysis of Variance; Area Under Curve; Case-Control Studies; Depressive Disorder; Double-Bli | 1996 |
HPA axis dysfunction in depression: correlation with monoamine system abnormalities.
Topics: Adrenergic alpha-Agonists; Adult; Apomorphine; Biogenic Monoamines; Clonidine; Depressive Disorder; | 1997 |
Serotonergic function and negative and depressive symptomatology in schizophrenia and major depression.
Topics: Adult; Anxiety; Depressive Disorder; Female; Fenfluramine; Humans; Hydrocortisone; Male; Prolactin; | 1997 |
5-HT brain function in affective disorder: d,l-fenfluramine-induced hormone release and clinical outcome in long-term lithium/carbamazepine prophylaxis.
Topics: Adult; Affective Disorders, Psychotic; Carbamazepine; Depressive Disorder; Female; Fenfluramine; Hum | 1997 |
Recovery from major depression is not associated with normalization of serotonergic function.
Topics: Adult; Depressive Disorder; Female; Fenfluramine; Humans; Male; Middle Aged; Prolactin; Selective Se | 1998 |
Assessment of serotonergic function in major depression using d-fenfluramine: relation to clinical variables and antidepressant response.
Topics: Adult; Area Under Curve; Depressive Disorder; Female; Fenfluramine; Humans; Hydrocortisone; Male; Mi | 1998 |
Prolactin response to d-fenfluramine in major depression before and after treatment with serotonin reuptake inhibitors.
Topics: Adult; Analysis of Variance; Depressive Disorder; Double-Blind Method; Female; Fenfluramine; Fluoxet | 1999 |
Prolactin response to dl-fenfluramine challenge before and after treatment with paroxetine.
Topics: Aged; Biomarkers; Depressive Disorder; Female; Fenfluramine; Humans; Male; Middle Aged; Paroxetine; | 2001 |
Hormone responses to fenfluramine and placebo challenge in endogenous depression.
Topics: Adult; Affective Disorders, Psychotic; Aged; Bipolar Disorder; Depressive Disorder; Double-Blind Met | 1992 |
D-fenfluramine-induced prolactin and cortisol release in major depression: response to treatment.
Topics: Adolescent; Adult; Amitriptyline; Depressive Disorder; Electroconvulsive Therapy; Female; Fenflurami | 1992 |
Serotonergic mechanisms of ECT: neuroendocrine evidence.
Topics: Antidepressive Agents; Depressive Disorder; Double-Blind Method; Electroconvulsive Therapy; Fenflura | 1992 |
Effect of clomipramine and lithium on fenfluramine-induced hormone release in major depression.
Topics: Adult; Bipolar Disorder; Clomipramine; Depressive Disorder; Double-Blind Method; Drug Therapy, Combi | 1992 |
Effect of fenfluramine on mood: a double-blind placebo-controlled trial.
Topics: Adult; Affect; Arousal; Bipolar Disorder; Depressive Disorder; Double-Blind Method; Female; Fenflura | 1992 |
Fenfluramine augmentation in tricyclic-refractory depression.
Topics: Adult; Aged; Bipolar Disorder; Depressive Disorder; Desipramine; Drug Therapy, Combination; Female; | 1990 |
Fenfluramine provocation of anxiety in patients with panic disorder.
Topics: Adult; Anxiety Disorders; Arousal; Clinical Trials as Topic; Depressive Disorder; Fear; Female; Fenf | 1989 |
Treatment of seasonal depression with d-fenfluramine.
Topics: Adult; Ambulatory Care; Clinical Trials as Topic; Depressive Disorder; Dietary Carbohydrates; Double | 1989 |
Nutrient imbalances in depressive disorders. Possible brain mechanisms.
Topics: Adult; Appetite; Brain; Clinical Trials as Topic; Depressive Disorder; Dietary Carbohydrates; Double | 1989 |
Tricyclic antidepressants for chronic low-back pain. Mechanisms of action and predictors of response.
Topics: Adult; Back Pain; Chronic Disease; Clinical Trials as Topic; Depressive Disorder; Desipramine; Doubl | 1986 |
A controlled trial of d-fenfluramine in bulimia nervosa.
Topics: Adolescent; Adult; Anorexia Nervosa; Attitude; Body Weight; Bulimia; Clinical Trials as Topic; Depre | 1988 |
Antidepressant drug therapy for bulimia: current status.
Topics: Antidepressive Agents; Bupropion; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method | 1986 |
A comparison of the acute effects of dextroamphetamine and fenfluramine in depression.
Topics: Adult; Aged; Clinical Trials as Topic; Depressive Disorder; Dextroamphetamine; Double-Blind Method; | 1985 |
54 other studies available for fenfluramine and Depressive Disorder
| Article | Year |
|---|---|
Brain serotonin, psychoactive drugs, and effects on reproduction.
Topics: Affect; Amphetamine-Related Disorders; Animals; Biological Clocks; Brain; Cognition Disorders; Depre | 2009 |
Central serotonergic activity is related to the aggressive behaviors of Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Aggression; Alzheimer Disease; Brain; Depressive Disorder; Down-Regulation; | 2002 |
Positron emission tomography of regional brain metabolic responses to a serotonergic challenge and lethality of suicide attempts in major depression.
Topics: Adult; Age Factors; Brain; Depressive Disorder; Female; Fenfluramine; Fluorodeoxyglucose F18; Glucos | 2003 |
Cigarette smoking, suicidal behavior, and serotonin function in major psychiatric disorders.
Topics: Adolescent; Adult; Aged; Comorbidity; Depressive Disorder; Female; Fenfluramine; Humans; Hydrocortis | 2003 |
The number of previous depressive episodes is positively associated with cortisol response to fenfluramine administration.
Topics: Adult; Depressive Disorder; Female; Fenfluramine; Humans; Hydrocortisone; Male; Middle Aged; Psychia | 2004 |
Distal colon motility as a predictor of antidepressant response to fenfluramine, imipramine and clomipramine.
Topics: Adolescent; Adult; Clomipramine; Colon; Depressive Disorder; Double-Blind Method; Female; Fenflurami | 1983 |
Clinical studies of monoamine receptors in the affective disorders and receptor changes with antidepressant treatment.
Topics: Clonidine; Clorgyline; Depressive Disorder; Fenfluramine; Growth Hormone; Humans; Hydrocortisone; Me | 1983 |
Plasma prolactin changes following fenfluramine in depressed patients compared to controls: an evaluation of central serotonergic responsivity in depression.
Topics: Adult; Depressive Disorder; Dopamine; Double-Blind Method; Female; Fenfluramine; Humans; Male; Prola | 1984 |
Fenfluramine challenge test as a predictor of outcome in major depression.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Depressive Disorder; Female; Fenfluramine; Humans; Hydro | 1993 |
Cortisol synthesis inhibition: a new treatment strategy for the clinical and endocrine manifestations of depression.
Topics: Adult; Depressive Disorder; Dose-Response Relationship, Drug; Female; Fenfluramine; Humans; Hydrocor | 1995 |
Major depression during dexfenfluramine treatment.
Topics: Depressive Disorder; Fenfluramine; Humans; Male; Middle Aged; Obesity | 1994 |
Controlling panic attacks with fenfluramine.
Topics: Adolescent; Adult; Body Mass Index; Body Weight; Bulimia; Depressive Disorder; Female; Fenfluramine; | 1994 |
Abnormal behavioral responses to fenfluramine in patients with affective and personality disorders. Correlation with increased serotonergic responsivity.
Topics: Adult; Anxiety; Arousal; Brain; Depressive Disorder; Female; Fenfluramine; Humans; Male; Middle Aged | 1994 |
The effects of fenfluramine on sleep and prolactin in depressed inpatients: a comparison of potential indices of brain serotonergic responsivity.
Topics: Adult; Brain; Depressive Disorder; Electroencephalography; Female; Fenfluramine; Humans; Male; Prola | 1993 |
Contrasting neuroendocrine responses in depression and chronic fatigue syndrome.
Topics: Adult; Depressive Disorder; Fatigue Syndrome, Chronic; Female; Fenfluramine; Humans; Hydrocortisone; | 1995 |
Demonstration in vivo of reduced serotonin responsivity in the brain of untreated depressed patients.
Topics: Adult; Brain; Deoxyglucose; Depressive Disorder; Female; Fenfluramine; Fluorodeoxyglucose F18; Gluco | 1996 |
Serotonin function in detoxified heroin abusers: prolactin and cortisol responses to fenfluramine challenge.
Topics: Adult; Aggression; Antisocial Personality Disorder; Depressive Disorder; Fenfluramine; Heroin Depend | 1995 |
Re: Endocrine responses to fenfluramine challenge in chronic fatigue syndrome.
Topics: Comorbidity; Depressive Disorder; Fatigue Syndrome, Chronic; Fenfluramine; Humans; Hydrocortisone; P | 1996 |
Enhancement of the prolactin response to d-fenfluramine in drug-naive schizophrenic patients.
Topics: Adult; Anxiety Disorders; Brain; Depressive Disorder; Female; Fenfluramine; Guilt; Humans; Hydrocort | 1996 |
Thyroxine replacement increases central 5-hydroxytryptamine activity and reduces depressive symptoms in hypothyroidism.
Topics: Adult; Depressive Disorder; Female; Fenfluramine; Humans; Hypothyroidism; Male; Middle Aged; Prognos | 1996 |
Prolactin response to fenfluramine and suicide attempt lethality in major depression.
Topics: Adult; Body Weight; Depressive Disorder; Female; Fenfluramine; Humans; Hydrocortisone; Longitudinal | 1996 |
Potential hazard of serotonin syndrome associated with dexfenfluramine hydrochloride (Redux)
Topics: Contraindications; Depressive Disorder; Drug Interactions; Fenfluramine; Humans; Obesity; Serotonin | 1996 |
Prolactin and cortisol responses to fenfluramine in Parkinson's disease.
Topics: Adult; Aged; Brain; Depressive Disorder; Female; Fenfluramine; Humans; Hydrocortisone; Male; Middle | 1996 |
Effect of valine on 5-HT neurotransmission and mood.
Topics: 1-Naphthylamine; Adult; Affect; Amino Acids, Branched-Chain; Amitriptyline; Analysis of Variance; An | 1996 |
Reduced serotonin responsivity in depression.
Topics: Brain; Cerebral Cortex; Depressive Disorder; Female; Fenfluramine; Functional Laterality; Glucose; H | 1997 |
Psychotic mania associated with fenfluramine and phentermine use.
Topics: 1-Naphthylamine; Bipolar Disorder; Depressive Disorder; Female; Fenfluramine; Humans; Middle Aged; O | 1997 |
Dexfenfluramine for weight gain secondary to psychotropics.
Topics: Adult; Antidepressive Agents; Appetite Depressants; Depressive Disorder; Female; Fenfluramine; Human | 1997 |
Serotonin: it's possible to have too much of a good thing.
Topics: Bulimia; Depressive Disorder; Fenfluramine; Heart Valve Diseases; Humans; Obsessive-Compulsive Disor | 1997 |
Banned drug 'still used until this month'.
Topics: Adolescent; Brain; Depressive Disorder; Ethics, Medical; Fenfluramine; Humans; Informed Consent; New | 1998 |
Prolactin response to D-fenfluramine in outpatients with major depression.
Topics: Adult; Analysis of Variance; Case-Control Studies; Depressive Disorder; Female; Fenfluramine; Humans | 1998 |
No effect of depression on [(15)O]H2O PET response to intravenous d-fenfluramine.
Topics: Administration, Oral; Adult; Brain; Cognition; Depressive Disorder; Female; Fenfluramine; Fluorodeox | 1998 |
Alterations in serotonergic responsiveness during cocaine withdrawal in rats: similarities to major depression in humans.
Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Behavior, Animal | 1998 |
Cholesterol and serotonin indices in depressed and suicidal patients.
Topics: Adult; Analysis of Variance; Bipolar Disorder; Case-Control Studies; Cholesterol; Depressive Disorde | 2001 |
Relationship between central and peripheral serotonin indexes in depressed and suicidal psychiatric inpatients.
Topics: Adult; Blood Platelets; Depressive Disorder; Female; Fenfluramine; Hospitalization; Humans; Hydroxyi | 1992 |
Cortisol and prolactin responses to d-fenfluramine in non-depressed patients with obsessive-compulsive disorder: a comparison with depressed and healthy controls.
Topics: Adult; Arousal; Brain; Depressive Disorder; Fenfluramine; Humans; Hydrocortisone; Male; Middle Aged; | 1992 |
Enhanced serotonergic responsivity following electroconvulsive therapy in patients with major depression.
Topics: Depressive Disorder; Double-Blind Method; Electroconvulsive Therapy; Female; Fenfluramine; Humans; M | 1992 |
Elevated cortisol concentrations and the diminished prolactin response to fenfluramine.
Topics: Depressive Disorder; Fenfluramine; Humans; Hydrocortisone; Prolactin | 1992 |
Growth hormone and other hormonal responses to clonidine in melancholic and nonmelancholic depressed subjects and controls.
Topics: Adrenocorticotropic Hormone; Adult; Blood Pressure; Clonidine; Depression; Depressive Disorder; Fema | 1991 |
HPA-axis hormones and prolactin responses to dextro-fenfluramine in depressed patients and healthy controls.
Topics: Adrenocorticotropic Hormone; Brain Chemistry; Depressive Disorder; Dexamethasone; Endorphins; Fenflu | 1991 |
Development of neuropharmacologically based behavioral assessments of impulsive aggressive behavior.
Topics: Adult; Aggression; Anger; Depressive Disorder; Female; Fenfluramine; Humans; Hypothalamus; Impulsive | 1991 |
Prolactin and cortisol responses to d-fenfluramine in major depression: evidence for diminished responsivity of central serotonergic function.
Topics: Adult; Ambulatory Care; Day Care, Medical; Depressive Disorder; Female; Fenfluramine; Hospitalizatio | 1991 |
Hormonal responses to fenfluramine in depressive subtypes.
Topics: Administration, Oral; Adult; Depressive Disorder; Female; Fenfluramine; Humans; Hydrocortisone; Male | 1990 |
Hormonal responses to fenfluramine in depressed and control subjects.
Topics: Adult; Bipolar Disorder; Depressive Disorder; Diazepam; Female; Fenfluramine; Humans; Hydrocortisone | 1990 |
Mechanisms of anxiogenic vulnerability in panic disorder.
Topics: Anxiety Disorders; Arousal; Depressive Disorder; Fear; Fenfluramine; Humans; Hydrocortisone; Panic; | 1990 |
Multiple hormone responses to stimulation with dl-fenfluramine in patients with major depression before and after antidepressive treatment.
Topics: Adult; Aged; Antidepressive Agents; Depressive Disorder; Female; Fenfluramine; Growth Hormone; Hormo | 1990 |
Differential responses to anxiogenic challenge studies in patients with major depressive disorder and panic disorder.
Topics: Administration, Oral; Adult; Anxiety Disorders; Arousal; Depressive Disorder; Diagnosis, Differentia | 1990 |
Cortisol, ACTH, prolactin and beta-endorphin responses to fenfluramine administration in major-depressed patients.
Topics: Adrenocorticotropic Hormone; Adult; beta-Endorphin; Brain; Depressive Disorder; Female; Fenfluramine | 1989 |
Neuroendocrine challenges in the diagnosis of depressive disorders.
Topics: Adult; Depressive Disorder; Female; Fenfluramine; Growth Hormone; Humans; Hydrocortisone; Male; Midd | 1989 |
Serotonergic studies in patients with affective and personality disorders. Correlates with suicidal and impulsive aggressive behavior.
Topics: Adult; Aggression; Alcoholism; Depressive Disorder; Fenfluramine; Humans; Impulsive Behavior; Male; | 1989 |
Plasma cortisol, prolactin, growth hormone, and immunoreactive beta-endorphin response to fenfluramine challenge in depressed patients.
Topics: Adult; beta-Endorphin; Depressive Disorder; Female; Fenfluramine; Growth Hormone; Humans; Hydrocorti | 1988 |
Fenfluramine stimulation of serum cortisol in patients with major affective disorders and healthy controls: further evidence for a central serotonergic action of lithium in man.
Topics: Adult; Bipolar Disorder; Blood Glucose; Depressive Disorder; Female; Fenfluramine; Humans; Hydrocort | 1985 |
Serotonergically induced hormonal responses and the antidepressant effect of total sleep deprivation in patients with major depression.
Topics: Depressive Disorder; Female; Fenfluramine; Hormones; Humans; Serotonin; Sleep Deprivation | 1988 |
The neuroendocrine response to fenfluramine in depressives and normal controls.
Topics: Adult; Depressive Disorder; Female; Fenfluramine; Humans; Hydrocortisone; Male; Middle Aged; Prolact | 1988 |
Diminished prolactin responses to repeated fenfluramine challenge in man.
Topics: Adult; Aged; Depressive Disorder; Fenfluramine; Humans; Male; Middle Aged; Personality Disorders; Pr | 1987 |