fenfluramine has been researched along with Depression in 40 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The ability of d-fenfluramine, a drug that releases brain serotonin and blocks its reuptake, to relieve premenstrual depression and excessive calorie and carbohydrate intakes was examined in 17 women with premenstrual syndrome." | 9.06 | d-Fenfluramine suppresses the increased calorie and carbohydrate intakes and improves the mood of women with premenstrual depression. ( Brzezinski, AA; Gleason, R; Greenfield, J; Nader, T; Wurtman, JJ; Wurtman, RJ, 1990) |
| "Measurements of subjective feeling in 20 patients receiving fenfluramine alternating with placebo and in 19 patients receiving phentermine alternating with placebo indicated that depression of mood occurred four days after fenfluramine withdrawal but no such depression was seen with phentermine." | 9.03 | Withdrawal depression in obese patients after fenfluramine treatment. ( Briggs, M; Steel, JM, 1972) |
| "The ability of d-fenfluramine, a drug that releases brain serotonin and blocks its reuptake, to relieve premenstrual depression and excessive calorie and carbohydrate intakes was examined in 17 women with premenstrual syndrome." | 5.06 | d-Fenfluramine suppresses the increased calorie and carbohydrate intakes and improves the mood of women with premenstrual depression. ( Brzezinski, AA; Gleason, R; Greenfield, J; Nader, T; Wurtman, JJ; Wurtman, RJ, 1990) |
| "Measurements of subjective feeling in 20 patients receiving fenfluramine alternating with placebo and in 19 patients receiving phentermine alternating with placebo indicated that depression of mood occurred four days after fenfluramine withdrawal but no such depression was seen with phentermine." | 5.03 | Withdrawal depression in obese patients after fenfluramine treatment. ( Briggs, M; Steel, JM, 1972) |
| " Lowering tryptophan levels by means of a tryptophan-deficient amino acid mixture, which reduced plasma tryptophan and serotonin (5-HT) levels, produced a lowering of mood in a subset of male subjects (that had no personal or family history of depression) relative to subjects that received a balanced amino acid mixture." | 3.70 | Influence of acute tryptophan depletion on mood and immune measures in healthy males. ( Anisman, H; Griffiths, J; Knott, VJ; Merali, Z; Ravindran, AV, 1999) |
| "22 severe binge eaters, 17 moderate binge eaters, and 16 non-binge eaters received phentermine resin 15mg/day and dl-fenfluramine 20mg three times daily over a 6 month period for weight loss." | 3.70 | Beneficial effects of pharmacotherapy on weight loss, depressive symptoms, and eating patterns in obese binge eaters and non-binge eaters. ( Alger, SA; Cerulli, J; Fein, S; Howard, L; Malone, M, 1999) |
| " Examples are cited from our studies of the effects of monoamine oxidase inhibitors and other antidepressants on noradrenergic-serotonergic interactions that affect melatonin release and other neuroendocrine responses, on some additional functional end-points, and on depressive mood and other symptoms in patients with depression or other tricyclic-responsive disorders." | 3.67 | How antidepressants work: cautionary conclusions based on clinical and laboratory studies of the longer-term consequences of antidepressant drug treatment. ( Aulakh, CS; Garrick, NA; Murphy, DL, 1986) |
| "Measures of subjective feeling used by five patients indicated that depression of mood occurred about four days after fenfluramine withdrawal." | 3.65 | Drugs of dependence though not of abuse: fenfluramine and imipramine. ( Brezinova, V; Briggs, M; Dunleavy, DL; Lewis, SA; Oswald, I, 1971) |
| " There was also a significant reduction in plasma dopamine beta-hydroxylase activity during fenfluramine treatment, suggesting that chronic administration may induce antiadrenergic effects which may be useful in the treatment of disorders affected by circulating catecholamines." | 2.64 | Reduction in plasma norepinephrine during fenfluramine treatment. ( de la Vega, CE; Lake, CR; Murphy, DL; Slater, S; Ziegler, MG, 1977) |
| "Fenfluramine was particularly effective in alleviating anxiety in patients who were initially higher in anxiety." | 2.64 | Emotional symptomatology in obese patients treated with fenfluramine and dextroamphetamine. ( Fisher, E; Hesbacher, P; Perloff, MM; Rickels, K; Rosenfeld, H, 1976) |
| "Dexfenfluramine also has an original effect on some food intake disorders." | 2.38 | [Dexfenfluramine and feeding behavior. Clinical and pharmacoclinical studies]. ( Fantino, M, 1989) |
| " The findings suggest that clonidine at a dosage of 1." | 1.28 | Growth hormone and other hormonal responses to clonidine in melancholic and nonmelancholic depressed subjects and controls. ( Boyce, P; Brodaty, H; Hickie, I; Mitchell, P; Parker, G; Smythe, G; Wilhelm, K, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (52.50) | 18.7374 |
| 1990's | 11 (27.50) | 18.2507 |
| 2000's | 7 (17.50) | 29.6817 |
| 2010's | 1 (2.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sher, L | 1 |
| Stanley, BH | 1 |
| Cooper, TB | 2 |
| Malone, KM | 2 |
| Mann, JJ | 2 |
| Oquendo, MA | 1 |
| Polter, A | 1 |
| Yang, S | 1 |
| Zmijewska, AA | 1 |
| van Groen, T | 1 |
| Paik, JH | 1 |
| Depinho, RA | 1 |
| Peng, SL | 1 |
| Jope, RS | 1 |
| Li, X | 1 |
| Licht, CL | 1 |
| Marcussen, AB | 1 |
| Wegener, G | 1 |
| Overstreet, DH | 1 |
| Aznar, S | 1 |
| Knudsen, GM | 1 |
| Jacobsen, JP | 1 |
| Siesser, WB | 1 |
| Sachs, BD | 1 |
| Peterson, S | 1 |
| Cools, MJ | 1 |
| Setola, V | 1 |
| Folgering, JH | 1 |
| Flik, G | 1 |
| Caron, MG | 1 |
| Rajewska, J | 1 |
| Rybakowski, JK | 1 |
| Johnson, PA | 1 |
| Hurley, RA | 1 |
| Benkelfat, C | 1 |
| Herpertz, SC | 1 |
| Taber, KH | 1 |
| McBride, PA | 1 |
| DeMeo, M | 1 |
| Keilp, J | 1 |
| Gorard, DA | 1 |
| Dewsnap, PA | 1 |
| Medbak, SH | 1 |
| Perry, LA | 1 |
| Libby, GW | 1 |
| Farthing, MJ | 1 |
| Herpertz, S | 1 |
| Steinmeyer, SM | 1 |
| Marx, D | 1 |
| Oidtmann, A | 1 |
| Sass, H | 1 |
| Cleare, AJ | 1 |
| McGregor, A | 1 |
| O'Keane, V | 1 |
| Gerra, G | 2 |
| Caccavari, R | 1 |
| Zaimovic, A | 2 |
| Palladino, M | 1 |
| Chittolini, B | 1 |
| Giucastro, G | 1 |
| Maestri, D | 1 |
| Monica, C | 1 |
| Fertonani-Affini, G | 1 |
| Delsignore, R | 2 |
| Brambilla, F | 2 |
| Coccaro, EF | 2 |
| Kavoussi, RJ | 1 |
| Trestman, RL | 1 |
| Gabriel, SM | 1 |
| Siever, LJ | 2 |
| Ramasubbu, R | 1 |
| Flint, A | 1 |
| Brown, G | 1 |
| Awad, G | 1 |
| Kennedy, S | 1 |
| Ravindran, AV | 1 |
| Griffiths, J | 1 |
| Merali, Z | 1 |
| Knott, VJ | 1 |
| Anisman, H | 1 |
| Alger, SA | 1 |
| Malone, M | 1 |
| Cerulli, J | 1 |
| Fein, S | 1 |
| Howard, L | 1 |
| Zambelli, U | 1 |
| Baroni, MC | 1 |
| Laviola, G | 1 |
| Macchia, T | 1 |
| Duval, F | 1 |
| Mokrani, MC | 1 |
| Correa, H | 1 |
| Bailey, P | 1 |
| Valdebenito, M | 1 |
| Monreal, J | 1 |
| Crocq, MA | 1 |
| Macher, JP | 1 |
| de la Vega, CE | 1 |
| Slater, S | 1 |
| Ziegler, MG | 1 |
| Lake, CR | 1 |
| Murphy, DL | 2 |
| Hudson, KD | 1 |
| Reuter, CJ | 1 |
| Rickels, K | 1 |
| Hesbacher, P | 1 |
| Fisher, E | 1 |
| Perloff, MM | 1 |
| Rosenfeld, H | 1 |
| Schindler, H | 1 |
| Bielesz, G | 1 |
| Mitchell, P | 1 |
| Smythe, G | 1 |
| Parker, G | 1 |
| Wilhelm, K | 1 |
| Brodaty, H | 1 |
| Boyce, P | 1 |
| Hickie, I | 1 |
| Brzezinski, AA | 1 |
| Wurtman, JJ | 1 |
| Wurtman, RJ | 1 |
| Gleason, R | 1 |
| Greenfield, J | 1 |
| Nader, T | 1 |
| Fantino, M | 1 |
| Aulakh, CS | 1 |
| Garrick, NA | 1 |
| Blouin, AG | 1 |
| Blouin, JH | 1 |
| Perez, EL | 1 |
| Bushnik, T | 1 |
| Zuro, C | 1 |
| Mulder, E | 1 |
| Benjamin, E | 1 |
| Rubinstein, K | 1 |
| Davis, KL | 1 |
| Oswald, I | 2 |
| Shannon, PJ | 1 |
| Leonard, D | 1 |
| Kidson, MA | 1 |
| Dykes, MH | 1 |
| Levin, A | 1 |
| Gaind, R | 1 |
| Steel, JM | 1 |
| Briggs, M | 2 |
| Ziance, RJ | 1 |
| Sipes, IG | 1 |
| Kinnard, WJ | 1 |
| Buckley, JP | 1 |
| Harding, T | 2 |
| Lewis, SA | 1 |
| Dunleavy, DL | 1 |
| Brezinova, V | 1 |
| Imlah, NW | 1 |
| Golding, D | 1 |
3 reviews available for fenfluramine and Depression
| Article | Year |
|---|---|
Understanding emotion regulation in borderline personality disorder: contributions of neuroimaging.
Topics: Aspartic Acid; Borderline Personality Disorder; Brain; Brain Mapping; Choline; Compulsive Personalit | 2003 |
A review of the CNS effects of fenfluramine, 780SE and norfenfluramine on animals and man.
Topics: Acetylcholine; Amphetamine; Analgesia; Animals; Behavior; Biogenic Amines; Body Temperature Regulati | 1975 |
[Dexfenfluramine and feeding behavior. Clinical and pharmacoclinical studies].
Topics: Animals; Depression; Feeding Behavior; Fenfluramine; Humans; Hyperphagia; Models, Biological; Obesit | 1989 |
10 trials available for fenfluramine and Depression
| Article | Year |
|---|---|
Serotonergic responses in depressed patients with or without a history of alcohol use disorders and healthy controls.
Topics: Adult; Aggression; Alcohol-Related Disorders; Depression; Emergency Services, Psychiatric; Female; F | 2008 |
The significance of aggression and impulsivity for self-mutilative behavior.
Topics: Adult; Aggression; Biomarkers; Depression; Disruptive, Impulse Control, and Conduct Disorders; Femal | 1995 |
Diminished serotonin-mediated prolactin responses in nondepressed stroke patients compared with healthy normal subjects.
Topics: Administration, Oral; Aged; Aged, 80 and over; Cerebrovascular Disorders; Cross-Over Studies; Depres | 1998 |
Reduction in plasma norepinephrine during fenfluramine treatment.
Topics: Adult; Blood Pressure; Body Weight; Clinical Trials as Topic; Depression; Depression, Chemical; Dopa | 1977 |
Emotional symptomatology in obese patients treated with fenfluramine and dextroamphetamine.
Topics: Adult; Anxiety; Body Weight; Clinical Trials as Topic; Depression; Dextroamphetamine; Emotions; Fema | 1976 |
d-Fenfluramine suppresses the increased calorie and carbohydrate intakes and improves the mood of women with premenstrual depression.
Topics: Adult; Appetite Regulation; Depression; Dietary Carbohydrates; Energy Intake; Female; Fenfluramine; | 1990 |
Treatment of bulimia with fenfluramine and desipramine.
Topics: Adolescent; Adult; Body Weight; Bulimia; Clinical Trials as Topic; Depression; Desipramine; Double-B | 1988 |
Evaluation of three anorexiants. Clortermine hydrochloride (voranil), fenfluramine hydrochloride (pondimin), and mazindol (sanorex).
Topics: Adolescent; Adult; Age Factors; Appetite Depressants; Clinical Trials as Topic; Depression; Diet, Re | 1974 |
Fenfluramine (Ponderax) in the treatment of obese psychiatric out-patients.
Topics: Anxiety Disorders; Appetite Depressants; Body Weight; Clinical Trials as Topic; Depression; Diarrhea | 1969 |
Withdrawal depression in obese patients after fenfluramine treatment.
Topics: Adult; Appetite; Appetite Depressants; Depression; Female; Fenfluramine; Humans; Middle Aged; Obesit | 1972 |
27 other studies available for fenfluramine and Depression
| Article | Year |
|---|---|
Forkhead box, class O transcription factors in brain: regulation and behavioral manifestation.
Topics: Affect; Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Anxiety; Behavior, Animal; | 2009 |
The brain 5-HT4 receptor binding is down-regulated in the Flinders Sensitive Line depression model and in response to paroxetine administration.
Topics: Animals; Antidepressive Agents, Second-Generation; Autoradiography; Brain; Citalopram; Depression; D | 2009 |
Deficient serotonin neurotransmission and depression-like serotonin biomarker alterations in tryptophan hydroxylase 2 (Tph2) loss-of-function mice.
Topics: Animals; Behavior, Animal; Biomarkers; Corticosterone; Depression; Disease Models, Animal; Extracell | 2012 |
Depression in premenopausal women: gonadal hormones and serotonergic system assessed by D-fenfluramine challenge test.
Topics: Adult; Depression; Estradiol; Female; Fenfluramine; Follicle Stimulating Hormone; Humans; Hydrocorti | 2003 |
Blunted serotonergic responsivity in depressed inpatients.
Topics: Administration, Oral; Adult; Age Factors; Depression; Female; Fenfluramine; Humans; Male; Middle Age | 1995 |
Central 5-hydroxytryptaminergic function in irritable bowel syndrome.
Topics: Adult; Anxiety; Central Nervous System; Colonic Diseases, Functional; Depression; Female; Fenflurami | 1995 |
Neuroendocrine evidence for an association between hypothyroidism, reduced central 5-HT activity and depression.
Topics: Adult; Depression; Female; Fenfluramine; Humans; Hydrocortisone; Hypothyroidism; Male; Middle Aged; | 1995 |
Serotonergic function in mothers of opioid addicts: correlation with comorbid depression.
Topics: Adult; Aggression; Analysis of Variance; Antisocial Personality Disorder; Case-Control Studies; Code | 1997 |
Serotonin function in human subjects: intercorrelations among central 5-HT indices and aggressiveness.
Topics: Adult; Aggression; Depression; Female; Fenfluramine; Humans; Male; Middle Aged; Personality Disorder | 1997 |
Influence of acute tryptophan depletion on mood and immune measures in healthy males.
Topics: Adolescent; Adult; Affect; Amino Acids; Cell Division; Depression; Fenfluramine; Humans; Interleukin | 1999 |
Beneficial effects of pharmacotherapy on weight loss, depressive symptoms, and eating patterns in obese binge eaters and non-binge eaters.
Topics: Adult; Appetite Depressants; Depression; Eating; Feeding and Eating Disorders; Female; Fenfluramine; | 1999 |
Neuroendocrine correlates of depression in abstinent heroin-dependent subjects.
Topics: Adrenergic alpha-Agonists; Adult; Analysis of Variance; Biomarkers; Brain; Bromocriptine; Case-Contr | 2000 |
Lack of effect of HPA axis hyperactivity on hormonal responses to d-fenfluramine in major depressed patients: implications for pathogenesis of suicidal behaviour.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Adult; Depression; Dexamethasone; Female; Fenfluramine; | 2001 |
The anorectic and hypotensive effect of fenfluramine in obesity.
Topics: Adolescent; Adult; Aged; Blood Pressure; Depression; Female; Fenfluramine; Humans; Male; Middle Aged | 1977 |
[Treatment of obesity with fenfluramine].
Topics: Adult; Aged; Blood Pressure; Body Weight; Depression; Drug Evaluation; Female; Fenfluramine; Humans; | 1975 |
Growth hormone and other hormonal responses to clonidine in melancholic and nonmelancholic depressed subjects and controls.
Topics: Adrenocorticotropic Hormone; Adult; Blood Pressure; Clonidine; Depression; Depressive Disorder; Fema | 1991 |
How antidepressants work: cautionary conclusions based on clinical and laboratory studies of the longer-term consequences of antidepressant drug treatment.
Topics: Adrenergic Fibers; Animals; Antidepressive Agents; Brain; Catecholamines; Depression; Fenfluramine; | 1986 |
Adrenergic and serotonergic receptor responsiveness in depression.
Topics: Clonidine; Depression; Fenfluramine; Growth Hormone; Humans; Middle Aged; Norepinephrine; Prolactin; | 1986 |
Letter: Fenfluramine and psychosis.
Topics: Depression; Fenfluramine; Humans; Psychoses, Substance-Induced; Sleep Wake Disorders | 1974 |
Letter: Fenfluramine and psychosis.
Topics: Adult; Depression; Female; Fenfluramine; Humans; Obesity; Psychoses, Substance-Induced; Schizophreni | 1974 |
Abuse of fenfluramine.
Topics: Depression; Euphoria; Fenfluramine; Humans; Male; Perception; Substance-Related Disorders; Thermosen | 1973 |
Central nervous system effects of fenfluramine hydrochloride.
Topics: Animals; Brain; Brain Chemistry; Central Nervous System; Depression; Dextroamphetamine; Dopamine; Dr | 1972 |
Depression following fenfluramine withdrawal.
Topics: Adult; Depression; Female; Fenfluramine; Humans; Middle Aged; Obesity; Substance Withdrawal Syndrome | 1972 |
Drugs of dependence though not of abuse: fenfluramine and imipramine.
Topics: Adult; Appetite Depressants; Body Weight; Depression; Dreams; Female; Fenfluramine; Fluorine; Humans | 1971 |
Unusual effect of fenfluramine.
Topics: Adult; Appetite Depressants; Depersonalization; Depression; Female; Fenfluramine; Fluorine; Humans; | 1970 |
Unusual effect of fenfluramine.
Topics: Appetite Depressants; Depression; Fenfluramine; Fluorine; Humans; Phenethylamines; Substance Withdra | 1970 |
Fenfluramine dependence.
Topics: Adult; Appetite Depressants; Depression; Female; Fenfluramine; Fluorine; Humans; Obesity; Phenethyla | 1971 |