fenfluramine has been researched along with Depression, Involutional in 23 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Depression, Involutional: Form of depression in those MIDDLE AGE with feelings of ANXIETY.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The prolactin response to fenfluramine (PRF) is generally believed to reflect the activity of the 5HT system and has been previously used to investigate 5HT activity in a variety of conditions, including alcoholism." | 3.74 | Prolactin response to fenfluramine in abstinent, alcohol-dependent patients. ( Davies, J; Frampton, C; Joyce, PR; Porter, RJ; Sellman, D, 2008) |
| "Patients with major depressive disorder (MDD) may have significant differences in cholesterol levels compared with healthy adults, while MDD patients with elevated cholesterol have a poorer prognosis for treatment response." | 1.32 | Serum cholesterol and serotonergic function in major depressive disorder. ( Alpert, JE; Fava, M; Hughes, ME; Mischoulon, D; Nierenberg, AA; Papakostas, GI; Petersen, T; Rosenbaum, JF, 2003) |
| "A D-fenfluramine test was performed in a sample of 18 healthy control subjects and in 85 drug-free inpatients with a DSM-III-R diagnosis of major depressive episode (49 with a history of suicide attempt, 36 without)." | 1.31 | Prolactin response to D-fenfluramine and suicidal behavior in depressed patients. ( Bailey, P; Corrêa, H; Crocq, MA; Diep, TS; Duval, F; Hodé, Y; Macher, JP; Mokrani, M; Staner, L; Trémeau, F, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (13.04) | 18.2507 |
| 2000's | 18 (78.26) | 29.6817 |
| 2010's | 2 (8.70) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sublette, ME | 2 |
| Milak, MS | 3 |
| Galfalvy, HC | 4 |
| Oquendo, MA | 8 |
| Malone, KM | 7 |
| Mann, JJ | 7 |
| Hibbeln, JR | 1 |
| Keilp, JG | 2 |
| Porter, RJ | 3 |
| Mulder, RT | 3 |
| Joyce, PR | 4 |
| Kegeles, LS | 1 |
| Slifstein, M | 1 |
| Ellis, SP | 1 |
| Xanthopoulos, E | 1 |
| Campbell, C | 2 |
| Oquendo, M | 1 |
| Van Heertum, RL | 2 |
| Meyer, JH | 1 |
| McMain, S | 1 |
| Kennedy, SH | 1 |
| Korman, L | 1 |
| Brown, GM | 1 |
| DaSilva, JN | 1 |
| Wilson, AA | 1 |
| Blak, T | 1 |
| Eynan-Harvey, R | 1 |
| Goulding, VS | 1 |
| Houle, S | 1 |
| Links, P | 1 |
| Echavarria, G | 1 |
| Grunebaum, MF | 1 |
| Burke, A | 1 |
| Barrera, A | 1 |
| Cooper, TB | 4 |
| John Mann, J | 2 |
| Sher, L | 4 |
| Li, S | 1 |
| Ellis, S | 1 |
| Brodsky, BS | 1 |
| Papakostas, GI | 1 |
| Petersen, T | 1 |
| Mischoulon, D | 1 |
| Hughes, ME | 1 |
| Alpert, JE | 2 |
| Nierenberg, AA | 2 |
| Rosenbaum, JF | 2 |
| Fava, M | 2 |
| Anderson, AD | 1 |
| Parsey, RV | 3 |
| Krunic, A | 1 |
| Milak, M | 1 |
| Anderson, A | 1 |
| Zalsman, G | 1 |
| Carballo, JJ | 1 |
| Sellman, D | 1 |
| Davies, J | 1 |
| Frampton, C | 1 |
| Duval, F | 2 |
| Mokrani, MC | 1 |
| Bailey, P | 2 |
| Correa, H | 2 |
| Diep, TS | 2 |
| Crocq, MA | 2 |
| Macher, JP | 2 |
| Degl'Innocenti, A | 1 |
| Agren, H | 1 |
| Zachrisson, O | 1 |
| Bäckman, L | 1 |
| New, AS | 1 |
| Woo-Ming, A | 1 |
| Mitropoulou, V | 1 |
| Silverman, J | 1 |
| Reynolds, D | 1 |
| Schopick, F | 1 |
| Trestman, RL | 1 |
| Siever, LJ | 1 |
| Mokrani, M | 1 |
| Trémeau, F | 1 |
| Staner, L | 1 |
| Hodé, Y | 1 |
| Vuolo, RD | 1 |
| Wright, EC | 1 |
| Gerra, G | 1 |
| Zaimovic, A | 1 |
| Zambelli, U | 1 |
| Delsignore, R | 1 |
| Baroni, MC | 1 |
| Laviola, G | 1 |
| Macchia, T | 1 |
| Brambilla, F | 1 |
| Patten, SB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Efficacy of the Proximate Administration of Oxytocin After a Traumatic Event in Preventing the Development of Post Traumatic Stress Disorder[NCT01039766] | 24 participants (Anticipated) | Interventional | 2010-02-28 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 trials available for fenfluramine and Depression, Involutional
| Article | Year |
|---|---|
Regional brain glucose uptake distinguishes suicide attempters from non-attempters in major depression.
Topics: Adult; Bipolar Disorder; Brain; Case-Control Studies; Caudate Nucleus; Depressive Disorder, Major; F | 2013 |
Baseline prolactin and L-tryptophan availability predict response to antidepressant treatment in major depression.
Topics: Administration, Oral; Adolescent; Adult; Antidepressive Agents, Tricyclic; Biological Availability; | 2003 |
Response of cortical metabolic deficits to serotonergic challenge in familial mood disorders.
Topics: Adult; Affect; Bipolar Disorder; Blood Glucose; Brain Mapping; Depressive Disorder, Major; Energy Me | 2003 |
Dysfunctional attitudes and 5-HT2 receptors during depression and self-harm.
Topics: Adolescent; Adult; Attitude; Brain Mapping; Cerebral Cortex; Clonidine; Depressive Disorder, Major; | 2003 |
The prolactin response to fenfluramine in depression: effects of melancholia and baseline cortisol.
Topics: Adolescent; Adult; Area Under Curve; Body Mass Index; Depressive Disorder, Major; Enzyme-Linked Immu | 2003 |
Prolactin response to fenfluramine administration in patients with unipolar and bipolar depression and healthy controls.
Topics: Adult; Age Distribution; Bipolar Disorder; Depressive Disorder, Major; Disease Susceptibility; Femal | 2003 |
Positron emission tomography of regional brain metabolic responses to a serotonergic challenge in major depressive disorder with and without borderline personality disorder.
Topics: Adult; Aggression; Borderline Personality Disorder; Brain Chemistry; Cerebral Cortex; Depressive Dis | 2005 |
Serotonin and the prediction of response time to fluoxetine in patients with mild depression.
Topics: Adult; Antidepressive Agents, Second-Generation; Depressive Disorder, Major; Double-Blind Method; Fe | 1999 |
15 other studies available for fenfluramine and Depression, Involutional
| Article | Year |
|---|---|
Polyunsaturated fatty acid associations with dopaminergic indices in major depressive disorder.
Topics: Adult; Aged; Analysis of Variance; Antidepressive Agents; Depressive Disorder, Major; Fatty Acids, U | 2014 |
Lower cortisol levels in depressed patients with comorbid post-traumatic stress disorder.
Topics: Adult; Analysis of Variance; Chi-Square Distribution; Comorbidity; Depressive Disorder, Major; Epile | 2003 |
Serum cholesterol and serotonergic function in major depressive disorder.
Topics: Adult; Cholesterol; Depressive Disorder, Major; Female; Fenfluramine; Humans; Hydrocortisone; Male; | 2003 |
Regional brain responses to serotonin in major depressive disorder.
Topics: Brain; Depressive Disorder, Major; Fenfluramine; Fluorodeoxyglucose F18; Glucose; Humans; Male; Pari | 2004 |
Posttraumatic mood disorder: a new concept.
Topics: Comorbidity; Depressive Disorder, Major; Fenfluramine; Humans; Hydrocortisone; Reference Values; Sel | 2005 |
Higher cortisol levels in spring and fall in patients with major depression.
Topics: Adult; Depressive Disorder, Major; Female; Fenfluramine; Humans; Hydrocortisone; Male; Prolactin; Se | 2005 |
Positron emission tomography study of regional brain metabolic responses to a serotonergic challenge in major depressive disorder with and without comorbid lifetime alcohol dependence.
Topics: Adult; Alcoholism; Brain; Brain Mapping; Depressive Disorder, Major; Female; Fenfluramine; Fluorodeo | 2007 |
Prolactin response to fenfluramine in abstinent, alcohol-dependent patients.
Topics: Adult; Alcoholism; Depressive Disorder, Major; Diagnostic and Statistical Manual of Mental Disorders | 2008 |
Thyroid axis activity and serotonin function in major depressive episode.
Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Depressive Disorder, Major; Female; Fenfluramine; Hu | 1999 |
The influence of prolactin response to d-fenfluramine on executive functioning in major depression.
Topics: Adult; Age Factors; Aged; Cognition; Depressive Disorder, Major; Female; Fenfluramine; Humans; Male; | 1999 |
Prolactin response to D-fenfluramine and suicidal behavior in depressed patients.
Topics: Adult; Depressive Disorder, Major; Female; Fenfluramine; Humans; Male; Middle Aged; Prolactin; Refer | 2000 |
Fenfluramine challenge in unipolar depression with and without anger attacks.
Topics: Adult; Aggression; Analysis of Variance; Anger; Depressive Disorder, Major; Female; Fenfluramine; Hu | 2000 |
Neuroendocrine correlates of depression in abstinent heroin-dependent subjects.
Topics: Adrenergic alpha-Agonists; Adult; Analysis of Variance; Biomarkers; Brain; Bromocriptine; Case-Contr | 2000 |
"Diet pills" and major depression in the Canadian population.
Topics: Appetite Depressants; Canada; Cross-Sectional Studies; Depressive Disorder, Major; Diet Fads; Female | 2001 |
Relationship of temperament and behaviour measures to the prolactin response to fenfluramine in depressed men.
Topics: Adolescent; Adult; Depressive Disorder, Major; Fenfluramine; Humans; Male; Mental Disorders; Middle | 2002 |