Page last updated: 2024-10-26

fenfluramine and Dementia

fenfluramine has been researched along with Dementia in 2 studies

Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.

Dementia: An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness.

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19901 (50.00)18.7374
1990's0 (0.00)18.2507
2000's1 (50.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Wolkowitz, OM1
Lupien, SJ1
Bigler, E1
Levin, RB1
Canick, J1
Pudel, VE1
Oetting, M1

Other Studies

2 other studies available for fenfluramine and Dementia

ArticleYear
The "steroid dementia syndrome": an unrecognized complication of glucocorticoid treatment.
    Annals of the New York Academy of Sciences, 2004, Volume: 1032

    Topics: Adult; Alopecia Areata; Anti-Inflammatory Agents; Appetite Depressants; Brain; Child; Dementia; Fema

2004
Eating in the laboratory: behavioural aspects of the positive energy balance.
    International journal of obesity, 1977, Volume: 1, Issue:4

    Topics: Adult; Aged; Appetite; Child; Child, Preschool; Cues; Dementia; Eating; Energy Intake; Energy Metabo

1977