fenfluramine has been researched along with Decerebrate Posturing in 5 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The threshold dose was two to three times higher in CD rats than in their intact controls, but the dynamic range of the dose-response curves of the two groups were overlapping with similar slopes of decline and with comparable maximal intake suppression." | 5.30 | Contribution of caudal brainstem to d-fenfluramine anorexia. ( Donahey, JC; Grill, HJ; Kaplan, JM; King, L, 1997) |
| " The threshold dose was two to three times higher in CD rats than in their intact controls, but the dynamic range of the dose-response curves of the two groups were overlapping with similar slopes of decline and with comparable maximal intake suppression." | 1.30 | Contribution of caudal brainstem to d-fenfluramine anorexia. ( Donahey, JC; Grill, HJ; Kaplan, JM; King, L, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 4 (80.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Grill, HJ | 1 |
| Donahey, JC | 1 |
| King, L | 1 |
| Kaplan, JM | 1 |
| Maj, J | 1 |
| Palider, W | 1 |
| Baran, L | 1 |
| Leitch, IM | 1 |
| Rawlow, A | 2 |
| Rechtman, MP | 1 |
| King, RG | 1 |
| Blackburn, TP | 1 |
| Cox, B | 1 |
| Thornber, CW | 1 |
| Pearce, RJ | 1 |
5 other studies available for fenfluramine and Decerebrate Posturing
| Article | Year |
|---|---|
Contribution of caudal brainstem to d-fenfluramine anorexia.
Topics: Animals; Anorexia; Appetite Depressants; Brain Stem; Decerebrate State; Fenfluramine; Male; Rats; Ra | 1997 |
The effects of serotonergic and antiserotonergic drugs on the flexor reflex of spinal rat: a proposed model to evaluate the action on the central serotonin receptor.
Topics: 5-Hydroxytryptophan; Amphetamine; Animals; Anthracenes; Clonidine; Cyproheptadine; Decerebrate State | 1976 |
Pharmacological evaluation of two novel analogues of mianserin: 2-N-carboxamidinonormianserin (FCC5) and 2-N-carboxamidonormianserin (FCC13).
Topics: Animals; Blood Pressure; Bronchoconstriction; Catalepsy; Central Nervous System; Decerebrate State; | 1992 |
A novel in vivo test for drugs affecting central serotonergic and adrenergic systems.
Topics: 5-Hydroxytryptophan; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Albuterol; Animals; Cl | 1990 |
Pharmacological studies in vivo with ICI 169,369, a chemically novel 5-HT2/5-HT1C receptor antagonist.
Topics: Amphetamine; Animals; Behavior, Animal; Blood Pressure; Body Temperature; Decerebrate State; Dogs; F | 1990 |