fenfluramine has been researched along with Compulsive Personality in 3 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study compared serotonergic function, as assessed by prolactin response to fenfluramine, in males with compulsive personality disorder, males with noncompulsive personality disorders, and normal control subjects." | 3.69 | Impulsivity and serotonergic function in compulsive personality disorder. ( Coccaro, EF; Hollander, E; Mitropoulou, V; Siever, LJ; Stein, DJ; Trestman, RL, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Johnson, PA | 1 |
| Hurley, RA | 1 |
| Benkelfat, C | 1 |
| Herpertz, SC | 1 |
| Taber, KH | 1 |
| Stein, DJ | 1 |
| Trestman, RL | 1 |
| Mitropoulou, V | 1 |
| Coccaro, EF | 1 |
| Hollander, E | 1 |
| Siever, LJ | 1 |
| Netter, P | 1 |
| Hennig, J | 1 |
| Rohrmann, S | 1 |
1 review available for fenfluramine and Compulsive Personality
| Article | Year |
|---|---|
Understanding emotion regulation in borderline personality disorder: contributions of neuroimaging.
Topics: Aspartic Acid; Borderline Personality Disorder; Brain; Brain Mapping; Choline; Compulsive Personalit | 2003 |
1 trial available for fenfluramine and Compulsive Personality
| Article | Year |
|---|---|
Psychobiological differences between the aggression and psychoticism dimension.
Topics: Adult; Aggression; Compulsive Personality Disorder; Cross-Over Studies; Double-Blind Method; Emotion | 1999 |
1 other study available for fenfluramine and Compulsive Personality
| Article | Year |
|---|---|
Impulsivity and serotonergic function in compulsive personality disorder.
Topics: Adult; Compulsive Personality Disorder; Fenfluramine; Humans; Impulsive Behavior; Male; Middle Aged; | 1996 |