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fenfluramine and Compensatory Hyperinsulinemia

fenfluramine has been researched along with Compensatory Hyperinsulinemia in 2 studies

Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.

Compensatory Hyperinsulinemia: A GLUCOSE-induced HYPERINSULINEMIA, a marker of insulin-resistant state. It is a mechanism to compensate for reduced sensitivity to insulin.

Research Excerpts

ExcerptRelevanceReference
" Benfluorex treatment improves insulin sensitivity and has antihyperglycemic and hypolipidemic effects in human beings and in experimental animals."4.78[Mode of action of benfluorex. Recent data]. ( Brindley, DN, 1992)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Brindley, DN1

Reviews

1 review available for fenfluramine and Compensatory Hyperinsulinemia

ArticleYear
[Mode of action of benfluorex. Recent data].
    Presse medicale (Paris, France : 1983), 1992, Sep-09, Volume: 21, Issue:28

    Topics: Animals; Arteriosclerosis; Diabetes Mellitus, Type 2; Drug Interactions; Fatty Acids; Female; Fenflu

1992

Other Studies

1 other study available for fenfluramine and Compensatory Hyperinsulinemia

ArticleYear
Insulin resistance, hyperinsulinemia and diabetes--contribution of benfluorex. Prague, 11 September 1992. Symposium proceedings.
    Diabetes/metabolism reviews, 1993, Volume: 9 Suppl 1

    Topics: Animals; Diabetes Mellitus, Type 2; Fenfluramine; Humans; Hyperinsulinism; Hypoglycemic Agents; Insu

1993