fenfluramine has been researched along with Colonic Diseases, Functional in 2 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Colonic Diseases, Functional: Chronic or recurrent colonic disorders without an identifiable structural or biochemical explanation. The widely recognized IRRITABLE BOWEL SYNDROME falls into this category.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gorard, DA | 1 |
| Dewsnap, PA | 1 |
| Medbak, SH | 1 |
| Perry, LA | 1 |
| Libby, GW | 1 |
| Farthing, MJ | 1 |
| Tanum, L | 1 |
| Bråtveit-Johansen, K | 1 |
| Malt, UF | 1 |
1 trial available for fenfluramine and Colonic Diseases, Functional
| Article | Year |
|---|---|
Fenfluramine challenge test predicts outcome in pharmacological treatment of patients with functional gastrointestinal disorder.
Topics: Adult; Aged; Antidepressive Agents, Second-Generation; Colonic Diseases, Functional; Double-Blind Me | 1999 |
1 other study available for fenfluramine and Colonic Diseases, Functional
| Article | Year |
|---|---|
Central 5-hydroxytryptaminergic function in irritable bowel syndrome.
Topics: Adult; Anxiety; Central Nervous System; Colonic Diseases, Functional; Depression; Female; Fenflurami | 1995 |