Page last updated: 2024-10-27

fenfluramine and Cognition Disorders

fenfluramine has been researched along with Cognition Disorders in 4 studies

Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.

Cognition Disorders: Disorders characterized by disturbances in mental processes related to learning, thinking, reasoning, and judgment.

Research Excerpts

ExcerptRelevanceReference
"Fenfluramine dosage was gradually increased to a standardized dose of 1."2.67Fenfluramine and methylphenidate in children with mental retardation and attention deficit hyperactivity disorder: laboratory effects. ( Aman, MG; Arnold, LE; Kern, RA; McGhee, DE, 1993)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19901 (25.00)18.7374
1990's2 (50.00)18.2507
2000's1 (25.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ayala, ME1
Aman, MG1
Kern, RA1
McGhee, DE1
Arnold, LE1
McCann, UD1
Eligulashvili, V1
Ricaurte, GA1
Brandon, S1

Trials

1 trial available for fenfluramine and Cognition Disorders

ArticleYear
Fenfluramine and methylphenidate in children with mental retardation and attention deficit hyperactivity disorder: laboratory effects.
    Journal of autism and developmental disorders, 1993, Volume: 23, Issue:3

    Topics: Adolescent; Attention; Attention Deficit Disorder with Hyperactivity; Child; Child, Preschool; Cogni

1993

Other Studies

3 other studies available for fenfluramine and Cognition Disorders

ArticleYear
Brain serotonin, psychoactive drugs, and effects on reproduction.
    Central nervous system agents in medicinal chemistry, 2009, Volume: 9, Issue:4

    Topics: Affect; Amphetamine-Related Disorders; Animals; Biological Clocks; Brain; Cognition Disorders; Depre

2009
Adverse neuropsychiatric events associated with dexfenfluramine and fenfluramine.
    Progress in neuro-psychopharmacology & biological psychiatry, 1998, Volume: 22, Issue:7

    Topics: Adolescent; Adult; Affect; Aged; Anxiety; Appetite Depressants; Cognition Disorders; Dexfenfluramine

1998
Unusual effect of fenfluramine.
    British medical journal, 1969, Nov-29, Volume: 4, Issue:5682

    Topics: Adolescent; Appetite Depressants; Cognition Disorders; Drug Synergism; Female; Fenfluramine; Fluorin

1969