fenfluramine has been researched along with Cognition Disorders in 4 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Cognition Disorders: Disorders characterized by disturbances in mental processes related to learning, thinking, reasoning, and judgment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fenfluramine dosage was gradually increased to a standardized dose of 1." | 2.67 | Fenfluramine and methylphenidate in children with mental retardation and attention deficit hyperactivity disorder: laboratory effects. ( Aman, MG; Arnold, LE; Kern, RA; McGhee, DE, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ayala, ME | 1 |
| Aman, MG | 1 |
| Kern, RA | 1 |
| McGhee, DE | 1 |
| Arnold, LE | 1 |
| McCann, UD | 1 |
| Eligulashvili, V | 1 |
| Ricaurte, GA | 1 |
| Brandon, S | 1 |
1 trial available for fenfluramine and Cognition Disorders
| Article | Year |
|---|---|
Fenfluramine and methylphenidate in children with mental retardation and attention deficit hyperactivity disorder: laboratory effects.
Topics: Adolescent; Attention; Attention Deficit Disorder with Hyperactivity; Child; Child, Preschool; Cogni | 1993 |
3 other studies available for fenfluramine and Cognition Disorders
| Article | Year |
|---|---|
Brain serotonin, psychoactive drugs, and effects on reproduction.
Topics: Affect; Amphetamine-Related Disorders; Animals; Biological Clocks; Brain; Cognition Disorders; Depre | 2009 |
Adverse neuropsychiatric events associated with dexfenfluramine and fenfluramine.
Topics: Adolescent; Adult; Affect; Aged; Anxiety; Appetite Depressants; Cognition Disorders; Dexfenfluramine | 1998 |
Unusual effect of fenfluramine.
Topics: Adolescent; Appetite Depressants; Cognition Disorders; Drug Synergism; Female; Fenfluramine; Fluorin | 1969 |