fenfluramine has been researched along with Cirrhosis in 3 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The authors describe the case of a simultaneous mitral bioprosthesis hypertrophic scaring and native aortic valve fibrosis during benfluorex therapy in a 40-year-old woman." | 7.78 | Mitral bioprosthesis hypertrophic scaring and native aortic valve fibrosis during benfluorex therapy. ( Ayme-Dietrich, E; Bischoff, N; Dallemand, R; Gasser, B; Lawson, R; Monassier, L, 2012) |
| "The authors describe the case of a simultaneous mitral bioprosthesis hypertrophic scaring and native aortic valve fibrosis during benfluorex therapy in a 40-year-old woman." | 3.78 | Mitral bioprosthesis hypertrophic scaring and native aortic valve fibrosis during benfluorex therapy. ( Ayme-Dietrich, E; Bischoff, N; Dallemand, R; Gasser, B; Lawson, R; Monassier, L, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bhattacharyya, S | 1 |
| Schapira, AH | 1 |
| Mikhailidis, DP | 1 |
| Davar, J | 1 |
| Ayme-Dietrich, E | 1 |
| Lawson, R | 1 |
| Gasser, B | 1 |
| Dallemand, R | 1 |
| Bischoff, N | 1 |
| Monassier, L | 1 |
| Rafel Ribera, J | 1 |
| Casañas Muñoz, R | 1 |
| Anguera Ferrando, N | 1 |
| Batalla Sahún, N | 1 |
| Castro Cels, A | 1 |
| Pujadas Capmany, R | 1 |
1 review available for fenfluramine and Cirrhosis
| Article | Year |
|---|---|
Drug-induced fibrotic valvular heart disease.
Topics: Antiparkinson Agents; Appetite Depressants; Cabergoline; Dexfenfluramine; Dopamine Agonists; Drug Mo | 2009 |
2 other studies available for fenfluramine and Cirrhosis
| Article | Year |
|---|---|
Mitral bioprosthesis hypertrophic scaring and native aortic valve fibrosis during benfluorex therapy.
Topics: Adult; Aortic Valve; Bioprosthesis; Cicatrix, Hypertrophic; Female; Fenfluramine; Fibrosis; Heart Va | 2012 |
[Valvular heart disease associated with benfluorex].
Topics: Appetite Depressants; Female; Fenfluramine; Fibrosis; Heart Valve Diseases; Heart Valve Prosthesis I | 2003 |