Page last updated: 2024-10-27

fenfluramine and Cirrhosis

fenfluramine has been researched along with Cirrhosis in 3 studies

Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.

Research Excerpts

ExcerptRelevanceReference
"The authors describe the case of a simultaneous mitral bioprosthesis hypertrophic scaring and native aortic valve fibrosis during benfluorex therapy in a 40-year-old woman."7.78Mitral bioprosthesis hypertrophic scaring and native aortic valve fibrosis during benfluorex therapy. ( Ayme-Dietrich, E; Bischoff, N; Dallemand, R; Gasser, B; Lawson, R; Monassier, L, 2012)
"The authors describe the case of a simultaneous mitral bioprosthesis hypertrophic scaring and native aortic valve fibrosis during benfluorex therapy in a 40-year-old woman."3.78Mitral bioprosthesis hypertrophic scaring and native aortic valve fibrosis during benfluorex therapy. ( Ayme-Dietrich, E; Bischoff, N; Dallemand, R; Gasser, B; Lawson, R; Monassier, L, 2012)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (66.67)29.6817
2010's1 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bhattacharyya, S1
Schapira, AH1
Mikhailidis, DP1
Davar, J1
Ayme-Dietrich, E1
Lawson, R1
Gasser, B1
Dallemand, R1
Bischoff, N1
Monassier, L1
Rafel Ribera, J1
Casañas Muñoz, R1
Anguera Ferrando, N1
Batalla Sahún, N1
Castro Cels, A1
Pujadas Capmany, R1

Reviews

1 review available for fenfluramine and Cirrhosis

ArticleYear
Drug-induced fibrotic valvular heart disease.
    Lancet (London, England), 2009, Aug-15, Volume: 374, Issue:9689

    Topics: Antiparkinson Agents; Appetite Depressants; Cabergoline; Dexfenfluramine; Dopamine Agonists; Drug Mo

2009

Other Studies

2 other studies available for fenfluramine and Cirrhosis

ArticleYear
Mitral bioprosthesis hypertrophic scaring and native aortic valve fibrosis during benfluorex therapy.
    Fundamental & clinical pharmacology, 2012, Volume: 26, Issue:2

    Topics: Adult; Aortic Valve; Bioprosthesis; Cicatrix, Hypertrophic; Female; Fenfluramine; Fibrosis; Heart Va

2012
[Valvular heart disease associated with benfluorex].
    Revista espanola de cardiologia, 2003, Volume: 56, Issue:2

    Topics: Appetite Depressants; Female; Fenfluramine; Fibrosis; Heart Valve Diseases; Heart Valve Prosthesis I

2003