Page last updated: 2024-10-27

fenfluramine and Chronic Illness

fenfluramine has been researched along with Chronic Illness in 15 studies

Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.

Research Excerpts

ExcerptRelevanceReference
"Fenfluramine was administered to 4 treatment-resistant chronic schizophrenic in-patients."6.66An open clinical trial of fenfluramine in chronic schizophrenia: a pilot study. ( Gadhvi, H; Kolakowska, T; Molyneux, S, 1987)
"Patients with chronic low-back pain and depression were treated double blind with desipramine or doxepin."5.06Tricyclic antidepressants for chronic low-back pain. Mechanisms of action and predictors of response. ( Ward, NG, 1986)
"The authors have evaluated the efficacy of d-fenfluramine, a serotoninergic anorectic drug, in 42 obese patients with non-insulin-dependent diabetes mellitus (NIDDM) who not very responded only to the hypocaloric diet or associated therapy with oral hypoglycemic agents."3.69[The treatment of the obese non-insulin-dependent patient with d-fenfluramine]. ( Coco, MP; Daniele, E, 1996)
"Fenfluramine was administered to 4 treatment-resistant chronic schizophrenic in-patients."2.66An open clinical trial of fenfluramine in chronic schizophrenia: a pilot study. ( Gadhvi, H; Kolakowska, T; Molyneux, S, 1987)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19907 (46.67)18.7374
1990's6 (40.00)18.2507
2000's2 (13.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Stocker, SD1
Muldoon, MF1
Sved, AF1
Kodas, E1
Galineau, L1
Bodard, S1
Vancassel, S1
Guilloteau, D1
Besnard, JC1
Chalon, S1
Gaul, G1
Blazek, G1
Deutsch, E1
Heeger, H1
Daniele, E1
Coco, MP1
Cerda, JJ1
Tanum, L1
BrÄtveit-Johansen, K1
Malt, UF1
Monteleone, P1
Tortorella, A1
Borriello, R1
Cassandro, P1
Maj, M1
Krasner, N1
Moore, MR1
Goldberg, A1
Booth, JC1
Frame, AH1
McLaren, AD1
Lemus, CZ1
Lieberman, JA1
Johns, CA1
Mayerhoff, DI1
Pollack, S1
Cooper, TB1
Novacenko, H1
Soper, HV1
Elliott, RO1
Rejzer, AA1
Marshall, BD1
Kolakowska, T1
Gadhvi, H1
Molyneux, S1
Ward, NG1
Shore, D1
Korpi, ER1
Bigelow, LB1
Zec, RF1
Wyatt, RJ1
Cameron, DC1
Kennedy, WP1
Samuel, PD1
Crompton, GK1
Stewart, E1

Trials

8 trials available for fenfluramine and Chronic Illness

ArticleYear
Fenfluramine and idiopathic pain: a serotonergic study in non-psychiatric patients with functional gastrointestinal disorder.
    Scandinavian journal of gastroenterology, 1998, Volume: 33, Issue:7

    Topics: Adult; Aging; Analysis of Variance; Chronic Disease; Female; Fenfluramine; Gastrointestinal Diseases

1998
Prolactin hyperresponsiveness to D-fenfluramine in drug-free schizophrenic patients: a placebo-controlled study.
    Biological psychiatry, 1999, Jun-15, Volume: 45, Issue:12

    Topics: Adolescent; Adult; Chronic Disease; Double-Blind Method; Female; Fenfluramine; Humans; Hydrocortison

1999
A trial of fenfluramine in the treatment of the chronic alcoholic patient.
    The British journal of psychiatry : the journal of mental science, 1976, Volume: 128

    Topics: Administration, Oral; Alcoholism; Chronic Disease; Clinical Trials as Topic; Dose-Response Relations

1976
Effects of fenfluramine on neuropsychological and communicative functioning in treatment-refractory schizophrenic patients.
    Journal of clinical psychopharmacology, 1990, Volume: 10, Issue:3

    Topics: Adult; Attention; Chronic Disease; Clinical Trials as Topic; Double-Blind Method; Drug Administratio

1990
An open clinical trial of fenfluramine in chronic schizophrenia: a pilot study.
    International clinical psychopharmacology, 1987, Volume: 2, Issue:1

    Topics: Adult; Antipsychotic Agents; Chronic Disease; Clinical Trials as Topic; Drug Therapy, Combination; F

1987
Tricyclic antidepressants for chronic low-back pain. Mechanisms of action and predictors of response.
    Spine, 1986, Volume: 11, Issue:7

    Topics: Adult; Back Pain; Chronic Disease; Clinical Trials as Topic; Depressive Disorder; Desipramine; Doubl

1986
Fenfluramine and chronic schizophrenia.
    Biological psychiatry, 1985, Volume: 20, Issue:3

    Topics: Adult; Age Factors; Cerebral Ventricles; Chronic Disease; Clinical Trials as Topic; Double-Blind Met

1985
Fenfluramine in corticosteroid-induced obesity.
    Current medical research and opinion, 1972, Volume: 1, Issue:3

    Topics: Adult; Appetite; Asthma; Blood Pressure; Body Weight; Chronic Disease; Clinical Trials as Topic; Fem

1972

Other Studies

7 other studies available for fenfluramine and Chronic Illness

ArticleYear
Blunted fenfluramine-evoked prolactin secretion in hypertensive rats.
    Hypertension (Dallas, Tex. : 1979), 2003, Volume: 42, Issue:4

    Topics: Acute Disease; Adrenergic alpha-Agonists; Animals; Blood Pressure; Chronic Disease; Fenfluramine; Hy

2003
Serotoninergic neurotransmission is affected by n-3 polyunsaturated fatty acids in the rat.
    Journal of neurochemistry, 2004, Volume: 89, Issue:3

    Topics: Age Factors; alpha-Linolenic Acid; Animals; Chronic Disease; Deficiency Diseases; Fatty Acids; Fatty

2004
[A case of chronic pulmonary hypertension after fenfluramine intake].
    Wiener klinische Wochenschrift, 1982, Nov-26, Volume: 94, Issue:22

    Topics: Chronic Disease; Female; Fenfluramine; Humans; Hypertension, Pulmonary; Middle Aged; Nifedipine; Obe

1982
[The treatment of the obese non-insulin-dependent patient with d-fenfluramine].
    La Clinica terapeutica, 1996, Volume: 147, Issue:4

    Topics: Adult; Aged; Appetite Depressants; Chronic Disease; Diabetes Mellitus; Diabetes Mellitus, Type 2; Dr

1996
The pharmacologic management of obesity.
    The Journal of the Florida Medical Association, 1997, Volume: 84, Issue:2

    Topics: Adult; Anti-Obesity Agents; Appetite Depressants; Body Mass Index; Body Weight; Chronic Disease; Fen

1997
Hormonal response to fenfluramine challenges in clozapine-treated schizophrenic patients.
    Biological psychiatry, 1991, Apr-01, Volume: 29, Issue:7

    Topics: Administration, Oral; Adult; Brain; Chronic Disease; Clozapine; Female; Fenfluramine; Humans; Male;

1991
Letter: Fenfluramine.
    The Medical journal of Australia, 1973, Nov-03, Volume: 2, Issue:18

    Topics: Chronic Disease; Fenfluramine; Humans; Obesity; Psoriasis

1973