fenfluramine has been researched along with Chronic Disease in 15 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fenfluramine was administered to 4 treatment-resistant chronic schizophrenic in-patients." | 6.66 | An open clinical trial of fenfluramine in chronic schizophrenia: a pilot study. ( Gadhvi, H; Kolakowska, T; Molyneux, S, 1987) |
| "Patients with chronic low-back pain and depression were treated double blind with desipramine or doxepin." | 5.06 | Tricyclic antidepressants for chronic low-back pain. Mechanisms of action and predictors of response. ( Ward, NG, 1986) |
| "The authors have evaluated the efficacy of d-fenfluramine, a serotoninergic anorectic drug, in 42 obese patients with non-insulin-dependent diabetes mellitus (NIDDM) who not very responded only to the hypocaloric diet or associated therapy with oral hypoglycemic agents." | 3.69 | [The treatment of the obese non-insulin-dependent patient with d-fenfluramine]. ( Coco, MP; Daniele, E, 1996) |
| "Fenfluramine was administered to 4 treatment-resistant chronic schizophrenic in-patients." | 2.66 | An open clinical trial of fenfluramine in chronic schizophrenia: a pilot study. ( Gadhvi, H; Kolakowska, T; Molyneux, S, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (46.67) | 18.7374 |
| 1990's | 6 (40.00) | 18.2507 |
| 2000's | 2 (13.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Stocker, SD | 1 |
| Muldoon, MF | 1 |
| Sved, AF | 1 |
| Kodas, E | 1 |
| Galineau, L | 1 |
| Bodard, S | 1 |
| Vancassel, S | 1 |
| Guilloteau, D | 1 |
| Besnard, JC | 1 |
| Chalon, S | 1 |
| Gaul, G | 1 |
| Blazek, G | 1 |
| Deutsch, E | 1 |
| Heeger, H | 1 |
| Daniele, E | 1 |
| Coco, MP | 1 |
| Cerda, JJ | 1 |
| Tanum, L | 1 |
| Bråtveit-Johansen, K | 1 |
| Malt, UF | 1 |
| Monteleone, P | 1 |
| Tortorella, A | 1 |
| Borriello, R | 1 |
| Cassandro, P | 1 |
| Maj, M | 1 |
| Krasner, N | 1 |
| Moore, MR | 1 |
| Goldberg, A | 1 |
| Booth, JC | 1 |
| Frame, AH | 1 |
| McLaren, AD | 1 |
| Lemus, CZ | 1 |
| Lieberman, JA | 1 |
| Johns, CA | 1 |
| Mayerhoff, DI | 1 |
| Pollack, S | 1 |
| Cooper, TB | 1 |
| Novacenko, H | 1 |
| Soper, HV | 1 |
| Elliott, RO | 1 |
| Rejzer, AA | 1 |
| Marshall, BD | 1 |
| Kolakowska, T | 1 |
| Gadhvi, H | 1 |
| Molyneux, S | 1 |
| Ward, NG | 1 |
| Shore, D | 1 |
| Korpi, ER | 1 |
| Bigelow, LB | 1 |
| Zec, RF | 1 |
| Wyatt, RJ | 1 |
| Cameron, DC | 1 |
| Kennedy, WP | 1 |
| Samuel, PD | 1 |
| Crompton, GK | 1 |
| Stewart, E | 1 |
8 trials available for fenfluramine and Chronic Disease
| Article | Year |
|---|---|
Fenfluramine and idiopathic pain: a serotonergic study in non-psychiatric patients with functional gastrointestinal disorder.
Topics: Adult; Aging; Analysis of Variance; Chronic Disease; Female; Fenfluramine; Gastrointestinal Diseases | 1998 |
Prolactin hyperresponsiveness to D-fenfluramine in drug-free schizophrenic patients: a placebo-controlled study.
Topics: Adolescent; Adult; Chronic Disease; Double-Blind Method; Female; Fenfluramine; Humans; Hydrocortison | 1999 |
A trial of fenfluramine in the treatment of the chronic alcoholic patient.
Topics: Administration, Oral; Alcoholism; Chronic Disease; Clinical Trials as Topic; Dose-Response Relations | 1976 |
Effects of fenfluramine on neuropsychological and communicative functioning in treatment-refractory schizophrenic patients.
Topics: Adult; Attention; Chronic Disease; Clinical Trials as Topic; Double-Blind Method; Drug Administratio | 1990 |
An open clinical trial of fenfluramine in chronic schizophrenia: a pilot study.
Topics: Adult; Antipsychotic Agents; Chronic Disease; Clinical Trials as Topic; Drug Therapy, Combination; F | 1987 |
Tricyclic antidepressants for chronic low-back pain. Mechanisms of action and predictors of response.
Topics: Adult; Back Pain; Chronic Disease; Clinical Trials as Topic; Depressive Disorder; Desipramine; Doubl | 1986 |
Fenfluramine and chronic schizophrenia.
Topics: Adult; Age Factors; Cerebral Ventricles; Chronic Disease; Clinical Trials as Topic; Double-Blind Met | 1985 |
Fenfluramine in corticosteroid-induced obesity.
Topics: Adult; Appetite; Asthma; Blood Pressure; Body Weight; Chronic Disease; Clinical Trials as Topic; Fem | 1972 |
7 other studies available for fenfluramine and Chronic Disease
| Article | Year |
|---|---|
Blunted fenfluramine-evoked prolactin secretion in hypertensive rats.
Topics: Acute Disease; Adrenergic alpha-Agonists; Animals; Blood Pressure; Chronic Disease; Fenfluramine; Hy | 2003 |
Serotoninergic neurotransmission is affected by n-3 polyunsaturated fatty acids in the rat.
Topics: Age Factors; alpha-Linolenic Acid; Animals; Chronic Disease; Deficiency Diseases; Fatty Acids; Fatty | 2004 |
[A case of chronic pulmonary hypertension after fenfluramine intake].
Topics: Chronic Disease; Female; Fenfluramine; Humans; Hypertension, Pulmonary; Middle Aged; Nifedipine; Obe | 1982 |
[The treatment of the obese non-insulin-dependent patient with d-fenfluramine].
Topics: Adult; Aged; Appetite Depressants; Chronic Disease; Diabetes Mellitus; Diabetes Mellitus, Type 2; Dr | 1996 |
The pharmacologic management of obesity.
Topics: Adult; Anti-Obesity Agents; Appetite Depressants; Body Mass Index; Body Weight; Chronic Disease; Fen | 1997 |
Hormonal response to fenfluramine challenges in clozapine-treated schizophrenic patients.
Topics: Administration, Oral; Adult; Brain; Chronic Disease; Clozapine; Female; Fenfluramine; Humans; Male; | 1991 |
Letter: Fenfluramine.
Topics: Chronic Disease; Fenfluramine; Humans; Obesity; Psoriasis | 1973 |