fenfluramine has been researched along with Choriocarcinoma in 1 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Choriocarcinoma: A malignant metastatic form of trophoblastic tumors. Unlike the HYDATIDIFORM MOLE, choriocarcinoma contains no CHORIONIC VILLI but rather sheets of undifferentiated cytotrophoblasts and syncytiotrophoblasts (TROPHOBLASTS). It is characterized by the large amounts of CHORIONIC GONADOTROPIN produced. Tissue origins can be determined by DNA analyses: placental (fetal) origin or non-placental origin (CHORIOCARCINOMA, NON-GESTATIONAL).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fenfluramine is an amphetamine analogue which has been widely used in the treatment of obesity." | 1.30 | The appetite suppressant d-fenfluramine induces apoptosis in human serotonergic cells. ( Bengel, D; Heils, A; Isaacs, KR; Lesch, KP; Murphy, DL, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bengel, D | 1 |
| Isaacs, KR | 1 |
| Heils, A | 1 |
| Lesch, KP | 1 |
| Murphy, DL | 1 |
1 other study available for fenfluramine and Choriocarcinoma
| Article | Year |
|---|---|
The appetite suppressant d-fenfluramine induces apoptosis in human serotonergic cells.
Topics: Apoptosis; Appetite Depressants; Biological Transport; Carrier Proteins; Cell Nucleus; Cell Size; Ch | 1998 |