fenfluramine has been researched along with Choline Deficiency in 1 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Choline Deficiency: A condition produced by a deficiency of CHOLINE in animals. Choline is known as a lipotropic agent because it has been shown to promote the transport of excess fat from the liver under certain conditions in laboratory animals. Combined deficiency of choline (included in the B vitamin complex) and all other methyl group donors causes liver cirrhosis in some animals. Unlike compounds normally considered as vitamins, choline does not serve as a cofactor in enzymatic reactions. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Serum triacylglycerol levels were decreased 60-76% by Pluronic L-81, fenfluramine, and choline deficiency compared with fat-fed controls." | 3.69 | A possible role for rat intestinal surfactant-like particles in transepithelial triacylglycerol transport. ( Alpers, DH; DeSchryver-Kecskemeti, K; Eliakim, R; Gramlich, TL; Mahmood, A; Yamagishi, F, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mahmood, A | 1 |
| Yamagishi, F | 1 |
| Eliakim, R | 1 |
| DeSchryver-Kecskemeti, K | 1 |
| Gramlich, TL | 1 |
| Alpers, DH | 1 |
1 other study available for fenfluramine and Choline Deficiency
| Article | Year |
|---|---|
A possible role for rat intestinal surfactant-like particles in transepithelial triacylglycerol transport.
Topics: Animals; Choline Deficiency; Chylomicrons; Corn Oil; Dietary Fats; Enzyme-Linked Immunosorbent Assay | 1994 |