fenfluramine has been researched along with Cholera Infantum in 2 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shuster, J | 1 |
| Tanum, L | 1 |
| Bråtveit-Johansen, K | 1 |
| Malt, UF | 1 |
1 trial available for fenfluramine and Cholera Infantum
| Article | Year |
|---|---|
Fenfluramine and idiopathic pain: a serotonergic study in non-psychiatric patients with functional gastrointestinal disorder.
Topics: Adult; Aging; Analysis of Variance; Chronic Disease; Female; Fenfluramine; Gastrointestinal Diseases | 1998 |
1 other study available for fenfluramine and Cholera Infantum
| Article | Year |
|---|---|
Fenfluramine and phentermine.
Topics: Adult; Appetite Depressants; Female; Fenfluramine; Gastrointestinal Diseases; Humans; Obesity; Phent | 1997 |