fenfluramine has been researched along with Child Behavior Disorders in 10 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Child Behavior Disorders: Disturbances considered to be pathological based on age and stage appropriateness, e.g., conduct disturbances and anaclitic depression. This concept does not include psychoneuroses, psychoses, or personality disorders with fixed patterns.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fifteen children with autism were treated with 60 mg d,l-fenfluramine (FEN) or placebo in a double-blind A-B-A protocol followed immediately by double-blind placebo-controlled crossover administration of FEN (total duration 62 weeks)." | 9.07 | Clinical and neurochemical effects of fenfluramine in children with autism. ( Cook, EH; Freedman, DX; Heller, W; Leventhal, BL; Morford, M; Ravitz, AJ, 1993) |
| "Fifteen children with autism were treated with 60 mg d,l-fenfluramine (FEN) or placebo in a double-blind A-B-A protocol followed immediately by double-blind placebo-controlled crossover administration of FEN (total duration 62 weeks)." | 5.07 | Clinical and neurochemical effects of fenfluramine in children with autism. ( Cook, EH; Freedman, DX; Heller, W; Leventhal, BL; Morford, M; Ravitz, AJ, 1993) |
| " This study examines the prolactin response to fenfluramine hydrochloride challenge in young boys who show clinically significant aggressive behavior or who are raised in a social environment that is conducive to the development of chronic aggression." | 3.69 | Neuroendocrine response to fenfluramine challenge in boys. Associations with aggressive behavior and adverse rearing. ( Cooper, TB; Coplan, JD; Davies, M; Fried, JE; Greenhill, L; Miller, LS; Parsons, B; Pine, DS; Shaffer, D; Wasserman, GA, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (30.00) | 18.7374 |
| 1990's | 5 (50.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Halperin, JM | 2 |
| Schulz, KP | 1 |
| McKay, KE | 2 |
| Sharma, V | 1 |
| Newcorn, JH | 2 |
| Gastaut, H | 1 |
| Leventhal, BL | 1 |
| Cook, EH | 1 |
| Morford, M | 1 |
| Ravitz, AJ | 1 |
| Heller, W | 1 |
| Freedman, DX | 1 |
| Koda, VH | 1 |
| Schwartz, ST | 1 |
| Pine, DS | 1 |
| Coplan, JD | 1 |
| Wasserman, GA | 1 |
| Miller, LS | 1 |
| Fried, JE | 1 |
| Davies, M | 1 |
| Cooper, TB | 2 |
| Greenhill, L | 1 |
| Shaffer, D | 1 |
| Parsons, B | 1 |
| Cherek, DR | 1 |
| Lane, SD | 1 |
| Stoff, DM | 2 |
| Pasatiempo, AP | 2 |
| Yeung, J | 1 |
| Bridger, WH | 2 |
| Rabinovich, H | 2 |
| Yeung, JH | 1 |
| McDermott, JF | 1 |
| De Villard, R | 1 |
| Dalery, J | 1 |
| Maillet, J | 1 |
| Chauvin, C | 1 |
| Flachaire, E | 1 |
| Renaud, B | 1 |
| Quincy, C | 1 |
3 trials available for fenfluramine and Child Behavior Disorders
| Article | Year |
|---|---|
Clinical and neurochemical effects of fenfluramine in children with autism.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adolescent; Autistic Disorder; Child; Child Behavior Disorders; Chil | 1993 |
Fenfluramine effects on impulsivity in a sample of adults with and without history of conduct disorder.
Topics: Adult; Child Behavior Disorders; Dopamine; Dose-Response Relationship, Drug; Fenfluramine; Humans; I | 2000 |
Neuroendocrine responses to challenge with dl-fenfluramine and aggression in disruptive behavior disorders of children and adolescents.
Topics: Adolescent; Aggression; Attention Deficit Disorder with Hyperactivity; Child; Child Behavior Disorde | 1992 |
7 other studies available for fenfluramine and Child Behavior Disorders
| Article | Year |
|---|---|
Familial correlates of central serotonin function in children with disruptive behavior disorders.
Topics: Aggression; Attention Deficit and Disruptive Behavior Disorders; Child; Child Behavior Disorders; Fe | 2003 |
[Efficacy of fenfluramine for the treatment of compulsive behavior disorders in psychotic children].
Topics: Child; Child Behavior Disorders; Compulsive Behavior; Fenfluramine; Humans; Psychotic Disorders | 1984 |
Gender differences in the prolactin response to fenfluramine challenge in children with disruptive behavior disorders.
Topics: Child; Child Behavior Disorders; Female; Fenfluramine; Humans; Male; Prolactin; Sex Factors; Time Fa | 1996 |
Neuroendocrine response to fenfluramine challenge in boys. Associations with aggressive behavior and adverse rearing.
Topics: Aggression; Child; Child Abuse; Child Behavior Disorders; Child Rearing; Fenfluramine; Humans; Male; | 1997 |
Test-retest reliability of the prolactin and cortisol responses to D,L-fenfluramine challenge in disruptive behavior disorders.
Topics: Arousal; Attention Deficit Disorder with Hyperactivity; Child; Child Behavior Disorders; Fenfluramin | 1992 |
Elvis Presley and the Rieger Award.
Topics: Autistic Disorder; Awards and Prizes; Child; Child Behavior Disorders; Fenfluramine; Humans; Psychia | 1989 |
[New indications for fenfluramine].
Topics: Child; Child Behavior Disorders; Fenfluramine; Humans | 1986 |