fenfluramine has been researched along with Chemical and Drug Induced Liver Injury in 9 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Two patients developed fulminant hepatic failure: 1 patient required liver transplantation, and the other patient died." | 1.32 | Hepatic injury in 12 patients taking the herbal weight loss AIDS Chaso or Onshido. ( Adachi, M; Horie, Y; Ishii, H; Kato, S; Kobayashi, H; Saito, H; Yoshioka, M, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (33.33) | 18.2507 |
| 2000's | 6 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kanda, T | 1 |
| Yokosuka, O | 1 |
| Tada, M | 1 |
| Kurihara, T | 1 |
| Yoshida, S | 1 |
| Suzuki, Y | 1 |
| Nagao, K | 1 |
| Saisho, H | 1 |
| Adachi, M | 1 |
| Saito, H | 1 |
| Kobayashi, H | 1 |
| Horie, Y | 1 |
| Kato, S | 1 |
| Yoshioka, M | 1 |
| Ishii, H | 1 |
| Kawaguchi, T | 1 |
| Harada, M | 1 |
| Arimatsu, H | 1 |
| Nagata, S | 1 |
| Koga, Y | 1 |
| Kuwahara, R | 1 |
| Hisamochi, A | 1 |
| Hino, T | 1 |
| Taniguchi, E | 1 |
| Kumemura, H | 1 |
| Hanada, S | 1 |
| Maeyama, M | 1 |
| Koga, H | 1 |
| Tomiyasu, N | 1 |
| Toyomasu, H | 1 |
| Kawaguchi, M | 1 |
| Kage, M | 1 |
| Kumashiro, R | 1 |
| Tanikawa, K | 1 |
| Sata, M | 1 |
| Kaddoumi, A | 1 |
| Wada, M | 1 |
| Nakashima, MN | 1 |
| Nakashima, K | 1 |
| Satoh, K | 1 |
| Nonaka, R | 1 |
| Tada, Y | 1 |
| Fukumori, N | 1 |
| Ogata, A | 1 |
| Yamada, A | 1 |
| Satoh, T | 1 |
| Nagai, F | 1 |
| Nightingale, SL | 1 |
| Lin, X | 1 |
| Levitsky, DA | 1 |
| King, JM | 1 |
| Campbell, TC | 1 |
| Mostefa-Kara, N | 1 |
| Pauwels, A | 1 |
| Pines, E | 1 |
| Biour, M | 1 |
| Levy, VG | 1 |
9 other studies available for fenfluramine and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
N-nitroso-fenfluramine hepatotoxicity resembling chronic hepatitis.
Topics: Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Drugs, Chinese Herbal; Female; Fenf | 2003 |
Hepatic injury in 12 patients taking the herbal weight loss AIDS Chaso or Onshido.
Topics: Adult; Chemical and Drug Induced Liver Injury; Dietary Supplements; Drugs, Chinese Herbal; Female; F | 2003 |
Summaries for patients. Liver injury in 12 patients taking the herbal weight loss aids Chaso or Onshido.
Topics: Adult; Chemical and Drug Induced Liver Injury; Dietary Supplements; Drugs, Chinese Herbal; Female; F | 2003 |
Severe hepatotoxicity associated with a N-nitrosofenfluramine-containing weight-loss supplement: report of three cases.
Topics: Adult; Anti-Obesity Agents; Chemical and Drug Induced Liver Injury; Dietary Supplements; Female; Fen | 2004 |
Hair analysis for fenfluramine and norfenfluramine as biomarkers for N-nitrosofenfluramine ingestion.
Topics: Animals; Appetite Depressants; Biomarkers; Chemical and Drug Induced Liver Injury; Chromatography, H | 2004 |
Effects of N-nitrosofenfluramine, a component of Chinese dietary supplement for weight loss, on CD-1 mice.
Topics: Administration, Oral; Animals; Anti-Obesity Agents; Brain; Chemical and Drug Induced Liver Injury; C | 2006 |
From the Food and Drug Administration.
Topics: Appetite Depressants; Chemical and Drug Induced Liver Injury; Chromans; Drug Labeling; Fenfluramine; | 1997 |
The promotion effect of anorectic drugs on aflatoxin B(1)-induced hepatic preneoplastic foci.
Topics: Adipose Tissue, Brown; Aflatoxin B1; Amphetamine; Animals; Appetite Depressants; Biomarkers; Body Te | 1999 |
Fatal hepatitis after herbal tea.
Topics: Aged; Beverages; Chemical and Drug Induced Liver Injury; Female; Fenfluramine; Humans; Necrosis | 1992 |