fenfluramine has been researched along with Chemical Dependence in 42 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Excerpt | Relevance | Reference |
---|---|---|
"Fenfluramine has been used for a number of years as a short-term adjunct to diet in the management of obesity." | 8.75 | Fenfluramine: a review of its pharmacological properties and therapeutic efficacy in obesity. ( Avery, GS; Brogden, RN; Pinder, RM; Sawyer, PR; Speight, TM, 1975) |
"Smokers had a blunted prolactin response to fenfluramine compared with nonsmokers without any alcoholism or antisocial personality effects." | 5.09 | Cigarette smoking decreases the prolactin response to serotonergic stimulation in subgroups of alcoholics and controls. ( Anthenelli, RM; Maxwell, RA, 2000) |
"Fenfluramine has been used for a number of years as a short-term adjunct to diet in the management of obesity." | 4.75 | Fenfluramine: a review of its pharmacological properties and therapeutic efficacy in obesity. ( Avery, GS; Brogden, RN; Pinder, RM; Sawyer, PR; Speight, TM, 1975) |
"Sixty male offenders with DSM-III-R personality disorders and 27 healthy staff controls were assessed using the Special Hospital Assessment of Personality and Socialisation (SHAPS), impulsivity and aggression ratings, d-fenfluramine challenge and plasma hormone concentrations." | 3.71 | Relationship between 5-HT function and impulsivity and aggression in male offenders with personality disorders. ( Anderson, IM; Deakin, JF; Dolan, M, 2001) |
"003 to 3 milligrams per kilogram of body weight, failed to maintain self-injection behavior in rhesus monkeys that had initiated and maintained responding for cocaine or methohexital." | 3.65 | Fenfluramine: amphetamine congener that fails to maintain drug-taking behavior in the rhesus monkey. ( Tessel, RE; Woods, JH, 1974) |
"Measures of subjective feeling used by five patients indicated that depression of mood occurred about four days after fenfluramine withdrawal." | 3.65 | Drugs of dependence though not of abuse: fenfluramine and imipramine. ( Brezinova, V; Briggs, M; Dunleavy, DL; Lewis, SA; Oswald, I, 1971) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 26 (61.90) | 18.7374 |
1990's | 4 (9.52) | 18.2507 |
2000's | 10 (23.81) | 29.6817 |
2010's | 2 (4.76) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Suyama, JA | 1 |
Sakloth, F | 1 |
Kolanos, R | 1 |
Glennon, RA | 1 |
Lazenka, MF | 1 |
Negus, SS | 2 |
Banks, ML | 2 |
Rothman, RB | 2 |
Blough, BE | 2 |
Baumann, MH | 2 |
Ayala, ME | 1 |
Johanson, CE | 1 |
Uhlenhuth, EH | 1 |
Kramer, K | 1 |
Azmitia, EC | 1 |
Whitaker-Azmitia, PM | 1 |
Locke, KW | 1 |
Levesque, TR | 1 |
Nicholson, KL | 1 |
Balster, RL | 1 |
Buydens-Branchey, L | 1 |
Branchey, M | 1 |
Hudson, J | 1 |
Rothman, M | 1 |
Fergeson, P | 1 |
McKernin, C | 1 |
Gerra, G | 2 |
Zaimovic, A | 1 |
Ferri, M | 1 |
Zambelli, U | 1 |
Timpano, M | 1 |
Neri, E | 1 |
Marzocchi, GF | 1 |
Delsignore, R | 1 |
Brambilla, F | 1 |
Rada, PV | 1 |
Hoebel, BG | 1 |
Lawless-Liday, C | 1 |
Force, RW | 1 |
Anthenelli, RM | 1 |
Maxwell, RA | 1 |
Dolan, M | 2 |
Anderson, IM | 1 |
Deakin, JF | 1 |
Haney, M | 1 |
Ward, AS | 1 |
Foltin, RW | 1 |
Deakin, WJ | 1 |
Roberts, N | 1 |
Anderson, I | 1 |
Griffiths, RR | 2 |
Brady, JV | 1 |
Snell, JD | 1 |
Bigelow, GE | 1 |
Liebson, I | 1 |
Kaliszak, J | 1 |
Götestam, KG | 3 |
Pinder, RM | 1 |
Brogden, RN | 1 |
Sawyer, PR | 1 |
Speight, TM | 1 |
Avery, GS | 1 |
Dare, GL | 1 |
Goldney, RD | 1 |
Rosenvinge, HP | 1 |
Levin, A | 4 |
Goudie, AJ | 1 |
Thornton, EW | 1 |
Andersson, BE | 1 |
Byrne, A | 1 |
Fishbein, DH | 1 |
Lozovsky, D | 1 |
Jaffe, JH | 1 |
Woods, JH | 1 |
Tessel, RE | 1 |
Oswald, I | 4 |
Gunne, LM | 1 |
Jorgensen, F | 1 |
Greenwood, MH | 1 |
Dykes, MH | 1 |
Lewis, SA | 1 |
Dunleavy, DL | 1 |
Brezinova, V | 1 |
Briggs, M | 1 |
Hawks, DV | 1 |
Harding, T | 1 |
De Groot, JC | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Treatment With Lorcaserin for Cocaine Use: The TLC Study[NCT03192995] | Phase 2 | 22 participants (Actual) | Interventional | 2018-01-01 | Terminated (stopped due to FDA alert regarding study drug safety) | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
To evaluate the adherence of lorcaserin vs. placebo, the investigators measured adherence as the frequency of taking the study drug as measured by the number of MEMS cap openings (wireless medication monitoring devices that record each opening as a real-time medication event). Cumulative percent adherence was calculated by dividing the frequency of openings at a given time point divided by the number of days since baseline. (NCT03192995)
Timeframe: 12 weeks
Intervention | percent adherence (Mean) |
---|---|
Experimental | 51.6 |
Control | 66.2 |
To determine the feasibility of retaining individuals on lorcaserin vs. placebo, the investigators have calculated the mean weekly percentage of follow-up visits of those randomized in the study (NCT03192995)
Timeframe: 12 weeks
Intervention | mean percent of visit retention (Mean) | |
---|---|---|
Treatment Group | Control Group | |
Mean Percent of Weekly Follow-up Visits by Treatment and Control Arms | 83 | 81 |
The outcome measure determines the proportion of self-reported past week cocaine use by Time-Line-Follow-back (TLFB) among lorcaserin and placebo groups at Baseline and at 12 weeks. (NCT03192995)
Timeframe: 12 weeks
Intervention | Participants (Count of Participants) | |
---|---|---|
Proportion of self-reported weekly cocaine use by Time-Line-Follow-Up (TLFU) at baseline | Proportion of self-reported weekly cocaine use by TLFU at Week 12 | |
Control | 6 | 6 |
Experimental | 12 | 7 |
The outcome measure determines the proportion of urine-positive samples with cocaine positivity among lorcaserin and placebo groups at Baseline and at Week 12 (NCT03192995)
Timeframe: Week 12
Intervention | Participants (Count of Participants) | |
---|---|---|
Urine positive samples with cocaine use at baseline | Urine positive samples with cocaine use at Week 12 | |
Control | 0 | 1 |
Treatment | 8 | 7 |
4 reviews available for fenfluramine and Chemical Dependence
Article | Year |
---|---|
Dopamine/serotonin releasers as medications for stimulant addictions.
Topics: Animals; Behavior, Addictive; Central Nervous System Stimulants; Cocaine; Dopamine; Dopamine Agents; | 2008 |
Fenfluramine: a review of its pharmacological properties and therapeutic efficacy in obesity.
Topics: Adult; Age Factors; Analgesics; Anticonvulsants; Appetite Depressants; Body Temperature; Central Ner | 1975 |
[Fenfluramine and drug dependence].
Topics: Appetite Depressants; Fenfluramine; Humans; Obesity; Psychoses, Substance-Induced; Substance-Related | 1973 |
[Side effects associated with prolonged use of fenfluramine].
Topics: Depersonalization; Diarrhea; Fatigue; Fenfluramine; Humans; Libido; Sleep; Substance-Related Disorde | 1973 |
6 trials available for fenfluramine and Chemical Dependence
Article | Year |
---|---|
Serotonergic function in cocaine addicts: prolactin responses to sequential D,L-fenfluramine challenges.
Topics: Administration, Oral; Adult; Alcoholism; Child of Impaired Parents; Cocaine-Related Disorders; Fathe | 1999 |
Cigarette smoking decreases the prolactin response to serotonergic stimulation in subgroups of alcoholics and controls.
Topics: Adolescent; Adult; Alcoholism; Analysis of Variance; Chi-Square Distribution; Fenfluramine; Humans; | 2000 |
Impulsivity, aggression, and neuroendocrine responses to serotonergic stimulation in substance abusers.
Topics: Adult; Aggression; Fenfluramine; Humans; Hydrocortisone; Impulsive Behavior; Male; Prolactin; Psycho | 1989 |
Subjective effects of two anorexigenic agents fenfluramine and AN 448 in amphetamine-dependent subjects.
Topics: Adult; Amphetamine; Appetite Depressants; Fenfluramine; Humans; Imidazoles; Male; Substance-Related | 1972 |
Evaluation of three anorexiants. Clortermine hydrochloride (voranil), fenfluramine hydrochloride (pondimin), and mazindol (sanorex).
Topics: Adolescent; Adult; Age Factors; Appetite Depressants; Clinical Trials as Topic; Depression; Diet, Re | 1974 |
Drugs and sleep.
Topics: Appetite Depressants; Clinical Trials as Topic; Diethylpropion; Fenfluramine; Humans; Phenethylamine | 1968 |
32 other studies available for fenfluramine and Chemical Dependence
Article | Year |
---|---|
Abuse-Related Neurochemical Effects of Para-Substituted Methcathinone Analogs in Rats: Microdialysis Studies of Nucleus Accumbens Dopamine and Serotonin.
Topics: Amphetamine; Animals; Behavior, Animal; Designer Drugs; Dopamine; Dopamine Plasma Membrane Transport | 2016 |
Decoding the Structure of Abuse Potential for New Psychoactive Substances: Structure-Activity Relationships for Abuse-Related Effects of 4-Substituted Methcathinone Analogs.
Topics: Amphetamine; Animals; Behavior, Animal; Dopamine Plasma Membrane Transport Proteins; Fenfluramine; H | 2017 |
Brain serotonin, psychoactive drugs, and effects on reproduction.
Topics: Affect; Amphetamine-Related Disorders; Animals; Biological Clocks; Brain; Cognition Disorders; Depre | 2009 |
Drug preferences in humans.
Topics: Adult; Arousal; Dextroamphetamine; Diazepam; Emotions; Fenfluramine; Humans; Reinforcement, Psycholo | 1982 |
In vitro release of [3H]5-hydroxytryptamine from fetal and maternal brain by drugs of abuse.
Topics: 3,4-Methylenedioxyamphetamine; Animals; Brain; Brain Chemistry; Cocaine; Designer Drugs; Female; Fen | 1994 |
Dexfenfluramine lacks amphetamine-like abuse potential.
Topics: Amphetamine; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Fenfluramine; Macaca mulat | 1996 |
Long-lasting effects of (+/-)3,4-methylenedioxymethamphetamine (ecstasy) on serotonin system function in humans.
Topics: Adolescent; Adult; Exploratory Behavior; Fenfluramine; Hallucinogens; Hostility; Humans; Hydrocortis | 2000 |
Supraadditive effect of d-fenfluramine plus phentermine on extracellular acetylcholine in the nucleus accumbens: possible mechanism for inhibition of excessive feeding and drug abuse.
Topics: Acetylcholine; Animals; Appetite Depressants; Dopamine; Drug Synergism; Feeding Behavior; Fenflurami | 2000 |
Lessons from the fenfluramines: antiobesity medications are frequently misused.
Topics: Anti-Obesity Agents; Appetite Depressants; Fenfluramine; Heart Valve Diseases; Humans; Substance-Rel | 2000 |
Relationship between 5-HT function and impulsivity and aggression in male offenders with personality disorders.
Topics: Adult; Aggression; Fenfluramine; Humans; Hydrocortisone; Impulsive Behavior; Male; Personality Disor | 2001 |
Neuroendocrine effects of d-fenfluramine and bromocriptine following repeated smoked cocaine in humans.
Topics: Adult; Analysis of Variance; Bromocriptine; Crack Cocaine; Fenfluramine; Humans; Hydrocortisone; Mal | 2001 |
Serotonergic and cognitive impairment in impulsive aggressive personality disordered offenders: are there implications for treatment?
Topics: Adult; Aggression; Analysis of Variance; Cluster Analysis; Fenfluramine; Humans; Hydrocortisone; Imp | 2002 |
Appetite suppressants as agonist substitution therapies for stimulant dependence.
Topics: Aminorex; Animals; Appetite Depressants; Dopamine; Fenfluramine; Male; Methamphetamine; Microdialysi | 2002 |
Relationship between anorectic and reinforcing properties of appetite suppressant drugs: implications for assessment of abuse liability.
Topics: Animals; Appetite; Appetite Depressants; Chlorphentermine; Cocaine; Dextroamphetamine; Diethylpropio | 1978 |
Therapeutic self-medication as a context for drug abuse research.
Topics: Adult; Body Weight; Dextroamphetamine; Drug Prescriptions; Female; Fenfluramine; Humans; Male; Metha | 1978 |
The discriminative properties of amphetamine analogues tested in self-administering rats under maintained stimulus control.
Topics: Amphetamines; Animals; Conditioning, Operant; Dextroamphetamine; Diethylpropion; Discrimination, Psy | 1977 |
Fenfluramine abuse.
Topics: Adolescent; Adult; Female; Fenfluramine; Humans; Male; Substance-Related Disorders | 1976 |
Letter: Abuse of fenfluramine.
Topics: Adult; Drug Tolerance; Female; Fenfluramine; Humans; Substance-Related Disorders | 1975 |
The non-medical misuse of fenfluramine by drug-dependent young South Africans.
Topics: Adolescent; Adult; Fenfluramine; Humans; Male; South Africa; Substance-Related Disorders | 1975 |
Effects of drug experience on drug induced conditioned taste aversions: studies with amphetamine and fenfluramine.
Topics: Animals; Avoidance Learning; Body Weight; Choice Behavior; Conditioning, Psychological; Dextroamphet | 1975 |
Assessment of reinforcing properties of amphetamine analogues in self-administering rats.
Topics: Amphetamine; Animals; Behavior, Animal; Diethylpropion; Fenfluramine; Humans; Male; Phenmetrazine; R | 1975 |
Probing dexfenfluramine.
Topics: Adult; Brain; Female; Fenfluramine; Humans; Male; Middle Aged; Substance-Related Disorders | 1992 |
Fenfluramine: amphetamine congener that fails to maintain drug-taking behavior in the rhesus monkey.
Topics: Animals; Behavior, Animal; Body Weight; Cocaine; Conditioning, Operant; Dose-Response Relationship, | 1974 |
Sleep.
Topics: Amobarbital; Appetite Depressants; Barbiturates; Dreams; Electroencephalography; Fenfluramine; Fluor | 1969 |
The pattern of drug-taking among drug-dependent South African national servicemen.
Topics: Adolescent; Adult; Age Factors; Alcoholism; Amphetamine; Barbiturates; Cannabis; Cocaine; Datura str | 1972 |
Drug-taking patterns in the National Service.
Topics: Cannabis; Fenfluramine; Heroin Dependence; Humans; Lysergic Acid Diethylamide; Military Medicine; So | 1973 |
Abuse of fenfluramine.
Topics: Depression; Euphoria; Fenfluramine; Humans; Male; Perception; Substance-Related Disorders; Thermosen | 1973 |
Drugs of dependence though not of abuse: fenfluramine and imipramine.
Topics: Adult; Appetite Depressants; Body Weight; Depression; Dreams; Female; Fenfluramine; Fluorine; Humans | 1971 |
Unusual effect of fenfluramine.
Topics: Appetite Depressants; Central Nervous System; Female; Fenfluramine; Fluorine; Humans; Male; Phenethy | 1969 |
Unusual effect of fenfluramine.
Topics: Appetite Depressants; Fenfluramine; Fluorine; Humans; Phenethylamines; Substance-Related Disorders | 1970 |
Fenfluramine dependence.
Topics: Adult; Appetite Depressants; Depression; Female; Fenfluramine; Fluorine; Humans; Obesity; Phenethyla | 1971 |
A survey of the usage of amphetamines in parts of the Sidney community.
Topics: Amphetamine; Australia; Diethylpropion; Fenfluramine; Humans; Phenmetrazine; Sleep; Substance-Relate | 1968 |