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fenfluramine and Cell Transformation, Neoplastic

fenfluramine has been researched along with Cell Transformation, Neoplastic in 1 studies

Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.

Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bouchard, C1
Marquardt, J1
BrĂ¡s, A1
Medema, RH1
Eilers, M1

Other Studies

1 other study available for fenfluramine and Cell Transformation, Neoplastic

ArticleYear
Myc-induced proliferation and transformation require Akt-mediated phosphorylation of FoxO proteins.
    The EMBO journal, 2004, Jul-21, Volume: 23, Issue:14

    Topics: Animals; Cell Line; Cell Proliferation; Cell Transformation, Neoplastic; Chromatin Immunoprecipitati

2004