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fenfluramine and Catatonia

fenfluramine has been researched along with Catatonia in 1 studies

Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.

Catatonia: A neuropsychiatric disorder characterized by one or more of the following essential features: immobility, mutism, negativism (active or passive refusal to follow commands), mannerisms, stereotypies, posturing, grimacing, excitement, echolalia, echopraxia, muscular rigidity, and stupor; sometimes punctuated by sudden violent outbursts, panic, or hallucinations. This condition may be associated with psychiatric illnesses (e.g., SCHIZOPHRENIA; MOOD DISORDERS) or organic disorders (NEUROLEPTIC MALIGNANT SYNDROME; ENCEPHALITIS, etc.). (From DSM-IV, 4th ed, 1994; APA, Thesaurus of Psychological Index Terms, 1994)

Research Excerpts

ExcerptRelevanceReference
"Baclofen, a GABAB receptor agonist can induce catatonia in rats."7.69Baclofen-induced catatonia: modification by serotonergic agents. ( Chopde, CT; Kasture, SB; Mandhane, SN, 1996)
"Baclofen, a GABAB receptor agonist can induce catatonia in rats."3.69Baclofen-induced catatonia: modification by serotonergic agents. ( Chopde, CT; Kasture, SB; Mandhane, SN, 1996)

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kasture, SB1
Mandhane, SN1
Chopde, CT1

Other Studies

1 other study available for fenfluramine and Catatonia

ArticleYear
Baclofen-induced catatonia: modification by serotonergic agents.
    Neuropharmacology, 1996, Volume: 35, Issue:5

    Topics: Animals; Baclofen; Catatonia; Fenfluramine; Male; Pindolol; Rats; Rats, Wistar; Serotonin Receptor A

1996