fenfluramine has been researched along with Callous-Unemotional Traits in 4 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The role of serotonin in aggression and impulsivity was examined by administering the serotonin-releasing drug, d, l-fenfluramine and measuring effects on aggressive and impulsive responding under controlled laboratory conditions." | 9.09 | Effects of d,l-fenfluramine on aggressive and impulsive responding in adult males with a history of conduct disorder. ( Cherek, DR; Lane, SD, 1999) |
| "The role of serotonin in human aggression was evaluated by administering D-fenfluramine and comparing the effects on laboratory measures of aggression, escape and impulsivity among subjects with and without a history of conduct disorder." | 9.09 | Acute effects of D-fenfluramine on simultaneous measures of aggressive escape and impulsive responses of adult males with and without a history of conduct disorder. ( Cherek, DR; Lane, SD, 2001) |
| "The role of serotonin in aggression and impulsivity was examined by administering the serotonin-releasing drug, d, l-fenfluramine and measuring effects on aggressive and impulsive responding under controlled laboratory conditions." | 5.09 | Effects of d,l-fenfluramine on aggressive and impulsive responding in adult males with a history of conduct disorder. ( Cherek, DR; Lane, SD, 1999) |
| "The role of serotonin in human aggression was evaluated by administering D-fenfluramine and comparing the effects on laboratory measures of aggression, escape and impulsivity among subjects with and without a history of conduct disorder." | 5.09 | Acute effects of D-fenfluramine on simultaneous measures of aggressive escape and impulsive responses of adult males with and without a history of conduct disorder. ( Cherek, DR; Lane, SD, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 3 (75.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Halperin, JM | 1 |
| Kalmar, JH | 1 |
| Schulz, KP | 1 |
| Marks, DJ | 1 |
| Sharma, V | 1 |
| Newcorn, JH | 1 |
| Cherek, DR | 2 |
| Lane, SD | 2 |
| Soloff, PH | 1 |
| Lynch, KG | 1 |
| Moss, HB | 1 |
2 trials available for fenfluramine and Callous-Unemotional Traits
| Article | Year |
|---|---|
Effects of d,l-fenfluramine on aggressive and impulsive responding in adult males with a history of conduct disorder.
Topics: Adult; Aggression; Conduct Disorder; Fenfluramine; Humans; Impulsive Behavior; Male; Reinforcement, | 1999 |
Acute effects of D-fenfluramine on simultaneous measures of aggressive escape and impulsive responses of adult males with and without a history of conduct disorder.
Topics: Adult; Aggression; Conduct Disorder; Disruptive, Impulse Control, and Conduct Disorders; Electrocard | 2001 |
2 other studies available for fenfluramine and Callous-Unemotional Traits
| Article | Year |
|---|---|
Elevated childhood serotonergic function protects against adolescent aggression in disruptive boys.
Topics: Adolescent; Adolescent Behavior; Adult; Aggression; Child; Child, Preschool; Conduct Disorder; Fenfl | 2006 |
Serotonin, impulsivity, and alcohol use disorders in the older adolescent: a psychobiological study.
Topics: Adolescent; Adult; Aggression; Alcohol-Induced Disorders; Analysis of Variance; Chi-Square Distribut | 2000 |