fenfluramine has been researched along with Bulimia in 16 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Bulimia: Eating an excess amount of food in a short period of time, as seen in the disorder of BULIMIA NERVOSA. It is caused by an abnormal craving for food, or insatiable hunger also known as ox hunger.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The purpose of this study was to assess the efficacy of the appetite suppressant d-fenfluramine in the treatment of binge eating disorder." | 9.08 | d-fenfluramine treatment of binge eating disorder. ( Berkowitz, R; Reiss, E; Stunkard, A; Tanrikut, C; Young, L, 1996) |
| "A double-blind, placebo-controlled trial of d-fenfluramine in bulimia nervosa was undertaken in order to assess its efficacy in controlling bulimic behavior and relieving more general symptoms." | 9.06 | A controlled trial of d-fenfluramine in bulimia nervosa. ( Checkley, SA; Eisler, I; Feldman, J; Russell, GF, 1988) |
| "d-Fenfluramine is a 5-HT agonist which decreases food intake and excessive carbohydrate intake in humans." | 6.67 | A placebo-controlled trial of d-fenfluramine in bulimia nervosa. ( Eisler, I; Fahy, TA; Russell, GF, 1993) |
| "The purpose of this study was to assess the efficacy of the appetite suppressant d-fenfluramine in the treatment of binge eating disorder." | 5.08 | d-fenfluramine treatment of binge eating disorder. ( Berkowitz, R; Reiss, E; Stunkard, A; Tanrikut, C; Young, L, 1996) |
| "For patients with bulimia nervosa, the fenfluramine-stimulated increase in serum prolactin concentration was significantly less than for controls." | 5.08 | Decreased serotonin function in bulimia nervosa. ( Cooper, TB; Finkelstein, DM; Jimerson, DC; Levine, JM; Metzger, ED; Wolfe, BE, 1997) |
| "A double-blind, placebo-controlled trial of d-fenfluramine in bulimia nervosa was undertaken in order to assess its efficacy in controlling bulimic behavior and relieving more general symptoms." | 5.06 | A controlled trial of d-fenfluramine in bulimia nervosa. ( Checkley, SA; Eisler, I; Feldman, J; Russell, GF, 1988) |
| "d-Fenfluramine is a 5-HT agonist which decreases food intake and excessive carbohydrate intake in humans." | 2.67 | A placebo-controlled trial of d-fenfluramine in bulimia nervosa. ( Eisler, I; Fahy, TA; Russell, GF, 1993) |
| "Fenfluramine has the potential to be of therapeutic value in patients with bulimia." | 2.38 | The role of pharmacotherapy in anorexia nervosa and bulimia. ( Tolstoi, LG, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (18.75) | 18.7374 |
| 1990's | 11 (68.75) | 18.2507 |
| 2000's | 2 (12.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Solyom, L | 2 |
| Fahy, TA | 3 |
| Eisler, I | 2 |
| Russell, GF | 4 |
| Lee, S | 1 |
| Chan, K | 1 |
| Stunkard, A | 1 |
| Berkowitz, R | 1 |
| Tanrikut, C | 1 |
| Reiss, E | 1 |
| Young, L | 1 |
| Jimerson, DC | 3 |
| Wolfe, BE | 2 |
| Metzger, ED | 2 |
| Finkelstein, DM | 2 |
| Cooper, TB | 2 |
| Levine, JM | 2 |
| Stahl, SM | 1 |
| Monteleone, P | 2 |
| Brambilla, F | 2 |
| Bortolotti, F | 2 |
| Ferraro, C | 1 |
| Maj, M | 2 |
| Kronvall, P | 1 |
| Isaksson, A | 1 |
| Theander, S | 1 |
| Lesem, MD | 1 |
| Hegg, AP | 1 |
| Brewerton, TD | 1 |
| Stevenson, RW | 1 |
| Tolstoi, LG | 1 |
| Checkley, SA | 1 |
| Feldman, J | 1 |
| Blouin, AG | 1 |
| Blouin, JH | 1 |
| Perez, EL | 1 |
| Bushnik, T | 1 |
| Zuro, C | 1 |
| Mulder, E | 1 |
2 reviews available for fenfluramine and Bulimia
| Article | Year |
|---|---|
Serotonin in human eating disorders.
Topics: Anorexia Nervosa; Bulimia; Feeding and Eating Disorders; Feeding Behavior; Fenfluramine; Humans; Ser | 1990 |
The role of pharmacotherapy in anorexia nervosa and bulimia.
Topics: Anorexia Nervosa; Antidepressive Agents; Antidepressive Agents, Tricyclic; Bulimia; Clomiphene; Coun | 1989 |
10 trials available for fenfluramine and Bulimia
| Article | Year |
|---|---|
A placebo-controlled trial of d-fenfluramine in bulimia nervosa.
Topics: Adolescent; Adult; Body Weight; Bulimia; Cognitive Behavioral Therapy; Combined Modality Therapy; Fe | 1993 |
Outcome and prognostic variables in bulimia nervosa.
Topics: Adolescent; Adult; Body Mass Index; Bulimia; Cognitive Behavioral Therapy; Combined Modality Therapy | 1993 |
d-fenfluramine treatment of binge eating disorder.
Topics: Appetite Depressants; Body Mass Index; Bulimia; Double-Blind Method; Female; Fenfluramine; Follow-Up | 1996 |
Decreased serotonin function in bulimia nervosa.
Topics: Adult; Body Weight; Bulimia; Cross-Sectional Studies; Dose-Response Relationship, Drug; Female; Fenf | 1997 |
Plasma prolactin response to D-fenfluramine is blunted in bulimic patients with frequent binge episodes.
Topics: Adult; Bulimia; Double-Blind Method; Female; Fenfluramine; Humans; Male; Prolactin; Psychiatric Stat | 1998 |
Serotonin function following remission from bulimia nervosa.
Topics: Adult; Amino Acids; Bulimia; Female; Fenfluramine; Hormones; Humans; Placebos; Prolactin; Reference | 2000 |
Serotonergic dysfunction across the eating disorders: relationship to eating behaviour, purging behaviour, nutritional status and general psychopathology.
Topics: Adult; Anorexia Nervosa; Bulimia; Double-Blind Method; Feeding Behavior; Female; Fenfluramine; Human | 2000 |
The clinical relevance of salivary amylase monitoring in bulimia nervosa.
Topics: Adult; Amylases; Bulimia; Female; Fenfluramine; Follow-Up Studies; Humans; Personality Inventory; Sa | 1992 |
A controlled trial of d-fenfluramine in bulimia nervosa.
Topics: Adolescent; Adult; Anorexia Nervosa; Attitude; Body Weight; Bulimia; Clinical Trials as Topic; Depre | 1988 |
Treatment of bulimia with fenfluramine and desipramine.
Topics: Adolescent; Adult; Body Weight; Bulimia; Clinical Trials as Topic; Depression; Desipramine; Double-B | 1988 |
4 other studies available for fenfluramine and Bulimia
| Article | Year |
|---|---|
Controlling panic attacks with fenfluramine.
Topics: Adolescent; Adult; Body Mass Index; Body Weight; Bulimia; Depressive Disorder; Female; Fenfluramine; | 1994 |
d-fenfluramine and cognitive therapy in bulimia nervosa.
Topics: Body Weight; Bulimia; Cognitive Behavioral Therapy; Combined Modality Therapy; Female; Fenfluramine; | 1993 |
Serotonin: it's possible to have too much of a good thing.
Topics: Bulimia; Depressive Disorder; Fenfluramine; Heart Valve Diseases; Humans; Obsessive-Compulsive Disor | 1997 |
The aphrodisiac effect of fenfluramine: two case reports of a possible side effect to the use of fenfluramine in the treatment of bulimia.
Topics: Adult; Aphrodisiacs; Bulimia; Dose-Response Relationship, Drug; Female; Fenfluramine; Humans; Libido | 1990 |