fenfluramine has been researched along with Brain Disorders in 4 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (75.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Martin, P | 1 |
| Reeder, T | 1 |
| Sourbron, J | 1 |
| de Witte, PAM | 1 |
| Gammaitoni, AR | 1 |
| Galer, BS | 1 |
| Santucci, A | 1 |
| Aguglia, F | 1 |
| Federico, M | 1 |
| De Mattia, G | 1 |
| Harvey, JA | 1 |
| McMaster, SE | 1 |
| Fuller, RW | 1 |
| Sjöholm, B | 1 |
| Sjöholm, M | 1 |
1 review available for fenfluramine and Brain Disorders
| Article | Year |
|---|---|
An Emerging Role for Sigma-1 Receptors in the Treatment of Developmental and Epileptic Encephalopathies.
Topics: Animals; Anticonvulsants; Brain Diseases; Epileptic Syndromes; Fenfluramine; Humans; Receptors, sigm | 2021 |
3 other studies available for fenfluramine and Brain Disorders
| Article | Year |
|---|---|
[Neuroendocrine syndromes with toxoplasmic origin: clinical and therapeutic considerations].
Topics: Adult; Brain Diseases; Child; Chloroquine; Female; Fenfluramine; Humans; Pyrimethamine; Sulfamethoxy | 1980 |
Comparison between the neurotoxic and serotonin-depleting effects of various halogenated derivatives of amphetamine in the rat.
Topics: Amphetamines; Animals; Brain; Brain Diseases; Fenfluramine; Histocytochemistry; Male; Neurons; Pheny | 1977 |
Adverse effects of fenfluramine.
Topics: Animals; Autistic Disorder; Brain Diseases; Child; Fenfluramine; Humans | 1988 |