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fenfluramine and Borderline Personality Disorder

fenfluramine has been researched along with Borderline Personality Disorder in 7 studies

Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.

Borderline Personality Disorder: A personality disorder marked by a pattern of instability of interpersonal relationships, self-image, and affects, and marked impulsivity beginning by early adulthood and present in a variety of contexts. (DSM-IV)

Research Excerpts

ExcerptRelevanceReference
" We tested the hypothesis that impulsive aggression in borderline personality disorder (BPD) may be associated with diminished serotonergic regulation in the prefrontal cortex, using positron-emission tomography (PET) neuroimaging during pharmacologic challenge with d,l fenfluramine (FEN)."9.09A fenfluramine-activated FDG-PET study of borderline personality disorder. ( Constantine, D; Greer, PJ; Kelly, TM; Meltzer, CC; Soloff, PH, 2000)
"Behavioral impulsivity in borderline personality disorder (BPD) is associated with indices of diminished central serotonergic function, independent of suicidal behavior, depression or alcohol use disorder."5.32Impulsivity, gender, and response to fenfluramine challenge in borderline personality disorder. ( Kelly, TM; Malone, KM; Mann, JJ; Soloff, PH; Strotmeyer, SJ, 2003)
" We tested the hypothesis that impulsive aggression in borderline personality disorder (BPD) may be associated with diminished serotonergic regulation in the prefrontal cortex, using positron-emission tomography (PET) neuroimaging during pharmacologic challenge with d,l fenfluramine (FEN)."5.09A fenfluramine-activated FDG-PET study of borderline personality disorder. ( Constantine, D; Greer, PJ; Kelly, TM; Meltzer, CC; Soloff, PH, 2000)
"Behavioral impulsivity in borderline personality disorder (BPD) is associated with indices of diminished central serotonergic function, independent of suicidal behavior, depression or alcohol use disorder."1.32Impulsivity, gender, and response to fenfluramine challenge in borderline personality disorder. ( Kelly, TM; Malone, KM; Mann, JJ; Soloff, PH; Strotmeyer, SJ, 2003)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (28.57)18.2507
2000's5 (71.43)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Soloff, PH3
Kelly, TM2
Strotmeyer, SJ1
Malone, KM2
Mann, JJ1
Johnson, PA1
Hurley, RA1
Benkelfat, C1
Herpertz, SC1
Taber, KH1
Oquendo, MA1
Krunic, A1
Parsey, RV1
Milak, M1
Anderson, A1
van Heertum, RL1
John Mann, J1
Meltzer, CC2
Becker, C1
Greer, PJ2
Constantine, D2
Coccaro, EF1
Klar, H1
Siever, LJ1
Martial, J1
Paris, J1
Leyton, M1
Zweig-Frank, H1
Schwartz, G1
Teboul, E1
Thavundayil, J1
Larue, S1
Ng Ying Kin, NM1
Vasa van Nair, NP1

Reviews

1 review available for fenfluramine and Borderline Personality Disorder

ArticleYear
Understanding emotion regulation in borderline personality disorder: contributions of neuroimaging.
    The Journal of neuropsychiatry and clinical neurosciences, 2003,Fall, Volume: 15, Issue:4

    Topics: Aspartic Acid; Borderline Personality Disorder; Brain; Brain Mapping; Choline; Compulsive Personalit

2003

Trials

3 trials available for fenfluramine and Borderline Personality Disorder

ArticleYear
Positron emission tomography of regional brain metabolic responses to a serotonergic challenge in major depressive disorder with and without borderline personality disorder.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2005, Volume: 30, Issue:6

    Topics: Adult; Aggression; Borderline Personality Disorder; Brain Chemistry; Cerebral Cortex; Depressive Dis

2005
Reduced prolactin response to fenfluramine challenge in personality disorder patients is not due to deficiency of pituitary lactotrophs.
    Biological psychiatry, 1994, Sep-01, Volume: 36, Issue:5

    Topics: Adult; Borderline Personality Disorder; Fenfluramine; Humans; Hypothalamo-Hypophyseal System; Male;

1994
A fenfluramine-activated FDG-PET study of borderline personality disorder.
    Biological psychiatry, 2000, Mar-15, Volume: 47, Issue:6

    Topics: Adolescent; Adult; Borderline Personality Disorder; Brain; Female; Fenfluramine; Fluorodeoxyglucose

2000

Other Studies

3 other studies available for fenfluramine and Borderline Personality Disorder

ArticleYear
Impulsivity, gender, and response to fenfluramine challenge in borderline personality disorder.
    Psychiatry research, 2003, Jul-15, Volume: 119, Issue:1-2

    Topics: Adult; Aggression; Body Mass Index; Borderline Personality Disorder; Diagnostic and Statistical Manu

2003
Gender differences in a fenfluramine-activated FDG PET study of borderline personality disorder.
    Psychiatry research, 2005, Apr-30, Volume: 138, Issue:3

    Topics: Borderline Personality Disorder; Brain; Female; Fenfluramine; Fluorodeoxyglucose F18; Humans; Male;

2005
Neuroendocrine study of serotonin function in female borderline personality disorder patients: a pilot study.
    Biological psychiatry, 1997, Oct-15, Volume: 42, Issue:8

    Topics: Adult; Borderline Personality Disorder; Female; Fenfluramine; Humans; Hydrocortisone; Luteal Phase;

1997