fenfluramine has been researched along with Borderline Personality Disorder in 7 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Borderline Personality Disorder: A personality disorder marked by a pattern of instability of interpersonal relationships, self-image, and affects, and marked impulsivity beginning by early adulthood and present in a variety of contexts. (DSM-IV)
| Excerpt | Relevance | Reference |
|---|---|---|
| " We tested the hypothesis that impulsive aggression in borderline personality disorder (BPD) may be associated with diminished serotonergic regulation in the prefrontal cortex, using positron-emission tomography (PET) neuroimaging during pharmacologic challenge with d,l fenfluramine (FEN)." | 9.09 | A fenfluramine-activated FDG-PET study of borderline personality disorder. ( Constantine, D; Greer, PJ; Kelly, TM; Meltzer, CC; Soloff, PH, 2000) |
| "Behavioral impulsivity in borderline personality disorder (BPD) is associated with indices of diminished central serotonergic function, independent of suicidal behavior, depression or alcohol use disorder." | 5.32 | Impulsivity, gender, and response to fenfluramine challenge in borderline personality disorder. ( Kelly, TM; Malone, KM; Mann, JJ; Soloff, PH; Strotmeyer, SJ, 2003) |
| " We tested the hypothesis that impulsive aggression in borderline personality disorder (BPD) may be associated with diminished serotonergic regulation in the prefrontal cortex, using positron-emission tomography (PET) neuroimaging during pharmacologic challenge with d,l fenfluramine (FEN)." | 5.09 | A fenfluramine-activated FDG-PET study of borderline personality disorder. ( Constantine, D; Greer, PJ; Kelly, TM; Meltzer, CC; Soloff, PH, 2000) |
| "Behavioral impulsivity in borderline personality disorder (BPD) is associated with indices of diminished central serotonergic function, independent of suicidal behavior, depression or alcohol use disorder." | 1.32 | Impulsivity, gender, and response to fenfluramine challenge in borderline personality disorder. ( Kelly, TM; Malone, KM; Mann, JJ; Soloff, PH; Strotmeyer, SJ, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 5 (71.43) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Soloff, PH | 3 |
| Kelly, TM | 2 |
| Strotmeyer, SJ | 1 |
| Malone, KM | 2 |
| Mann, JJ | 1 |
| Johnson, PA | 1 |
| Hurley, RA | 1 |
| Benkelfat, C | 1 |
| Herpertz, SC | 1 |
| Taber, KH | 1 |
| Oquendo, MA | 1 |
| Krunic, A | 1 |
| Parsey, RV | 1 |
| Milak, M | 1 |
| Anderson, A | 1 |
| van Heertum, RL | 1 |
| John Mann, J | 1 |
| Meltzer, CC | 2 |
| Becker, C | 1 |
| Greer, PJ | 2 |
| Constantine, D | 2 |
| Coccaro, EF | 1 |
| Klar, H | 1 |
| Siever, LJ | 1 |
| Martial, J | 1 |
| Paris, J | 1 |
| Leyton, M | 1 |
| Zweig-Frank, H | 1 |
| Schwartz, G | 1 |
| Teboul, E | 1 |
| Thavundayil, J | 1 |
| Larue, S | 1 |
| Ng Ying Kin, NM | 1 |
| Vasa van Nair, NP | 1 |
1 review available for fenfluramine and Borderline Personality Disorder
| Article | Year |
|---|---|
Understanding emotion regulation in borderline personality disorder: contributions of neuroimaging.
Topics: Aspartic Acid; Borderline Personality Disorder; Brain; Brain Mapping; Choline; Compulsive Personalit | 2003 |
3 trials available for fenfluramine and Borderline Personality Disorder
| Article | Year |
|---|---|
Positron emission tomography of regional brain metabolic responses to a serotonergic challenge in major depressive disorder with and without borderline personality disorder.
Topics: Adult; Aggression; Borderline Personality Disorder; Brain Chemistry; Cerebral Cortex; Depressive Dis | 2005 |
Reduced prolactin response to fenfluramine challenge in personality disorder patients is not due to deficiency of pituitary lactotrophs.
Topics: Adult; Borderline Personality Disorder; Fenfluramine; Humans; Hypothalamo-Hypophyseal System; Male; | 1994 |
A fenfluramine-activated FDG-PET study of borderline personality disorder.
Topics: Adolescent; Adult; Borderline Personality Disorder; Brain; Female; Fenfluramine; Fluorodeoxyglucose | 2000 |
3 other studies available for fenfluramine and Borderline Personality Disorder
| Article | Year |
|---|---|
Impulsivity, gender, and response to fenfluramine challenge in borderline personality disorder.
Topics: Adult; Aggression; Body Mass Index; Borderline Personality Disorder; Diagnostic and Statistical Manu | 2003 |
Gender differences in a fenfluramine-activated FDG PET study of borderline personality disorder.
Topics: Borderline Personality Disorder; Brain; Female; Fenfluramine; Fluorodeoxyglucose F18; Humans; Male; | 2005 |
Neuroendocrine study of serotonin function in female borderline personality disorder patients: a pilot study.
Topics: Adult; Borderline Personality Disorder; Female; Fenfluramine; Humans; Hydrocortisone; Luteal Phase; | 1997 |