fenfluramine has been researched along with Body Weight in 295 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of the serotonergic agent dexfenfluramine on weight loss, blood pressure, insulin sensitivity and serum lipid levels was determined in a 3-month randomised, double-blind, placebo controlled parallel design study in 50 obese subjects (body mass index 30-44 kg/m2)." | 9.08 | Effect of dexfenfluramine on body weight, blood pressure, insulin resistance and serum cholesterol in obese individuals. ( Gamble, G; Holdaway, IM; Wallace, E; Westbrooke, L, 1995) |
| "3 ng/mL, means +/- SE), the clinical and metabolic effects of benfluorex (B), a lipid-lowering drug able to improve insulin sensitivity." | 9.08 | Benfluorex in obese noninsulin dependent diabetes mellitus patients poorly controlled by insulin: a double blind study versus placebo. ( Camisasca, R; Cassisa, C; Pacchioni, M; Piatti, PM; Pontiroli, AE; Pozza, G, 1996) |
| "Dexfenfluramine lowers body weight in obese patients with upper and lower body obesity and reduces the cardiovascular risk factors clustering in upper body obesity." | 9.08 | The effects of dexfenfluramine on weight loss and cardiovascular risk factors in female patients with upper and lower body obesity. ( Adler, G; Ditschuneit, HH; Flechtner-Mors, M, 1996) |
| "To identify parameters predictive of weight loss during treatment with d-fenfluramine." | 9.08 | Predictors of weight loss during treatment with d-fenfluramine. ( Hopman, E; Meinders, AE; Pijl, H; Toornvliet, AC; Westendorp, RG, 1997) |
| "The aim of this work was to investigate the long-term changes of body weight and cardiovascular risk factors after weight reduction with dexfenfluramine (dF) compared to placebo (pI) and additional group therapy." | 9.07 | Long-term changes of body weight and cardiovascular risk factors after weight reduction with group therapy and dexfenfluramine. ( Blomberg, I; Luft, D; Pfohl, M; Schmülling, RM, 1994) |
| "The purpose of this study was to determine the effects of dexfenfluramine on body weight and post-prandial thermogenesis in obese subjects." | 9.07 | Effects of dexfenfluramine treatment on body weight and postprandial thermogenesis in obese subjects. A double-blind placebo-controlled study. ( Lafreniere, F; Lambert, J; Rasio, E; Serri, O, 1993) |
| " Pharmacological treatment of obesity has evolved in recent years with the development and licensing of potent serotonin agonists, such as dexfenfluramine (D-F)." | 9.07 | Body weight evolution during dexfenfluramine treatment after initial weight control. ( Finer, N, 1992) |
| "The effect of dexfenfluramine (dF) on body weight, blood pressure and noradrenergic activity were studied in 30 obese hypertensive patients randomly divided into two groups and treated for 3 months either with dF (30 mg daily; 16 subjects) or placebo (Pl; 14 subjects)." | 9.07 | Effect of dexfenfluramine treatment on body weight, blood pressure and noradrenergic activity in obese hypertensive patients. ( Detry, JM; Kolanowski, J; Vanbutsele, R; Younis, LT, 1992) |
| "We report a 12 month double-blind randomized crossover trial of fenfluramine in 20 children with the syndrome of autism." | 9.06 | A controlled crossover trial of fenfluramine in autism. ( Badcock, NR; Oades, RD; Sawyer, MG; Spence, JG; Stern, LM; Walker, MK, 1990) |
| "A double blind trial was conducted to determine the effect of fenfluramine on the weight and behaviour of patients with the Prader-Willi syndrome." | 9.06 | Fenfluramine in Prader-Willi syndrome: a double blind, placebo controlled trial. ( Pendergast, A; Selikowitz, M; Sunman, J; Wright, S, 1990) |
| "A double-blind, placebo-controlled trial of d-fenfluramine in bulimia nervosa was undertaken in order to assess its efficacy in controlling bulimic behavior and relieving more general symptoms." | 9.06 | A controlled trial of d-fenfluramine in bulimia nervosa. ( Checkley, SA; Eisler, I; Feldman, J; Russell, GF, 1988) |
| "Fenfluramine was administered to 14 outpatient children with the syndrome of autism to determine whether previously produced decreases in blood serotonin concentrations and clinical improvements could be reinstituted." | 9.05 | Study of fenfluramine in outpatients with the syndrome of autism. ( Freeman, BJ; Geller, E; Novak, P; Ritvo, ER; Schroth, P; Yokota, A; Yuwiler, A, 1984) |
| "Reports dealing with long-term effects of fenfluramines on brain serotonin neurons, body weight, and pulmonary function in animals and humans." | 8.79 | Brain serotonin neurotoxicity and primary pulmonary hypertension from fenfluramine and dexfenfluramine. A systematic review of the evidence. ( McCann, UD; Ricaurte, GA; Rubin, LJ; Seiden, LS, 1997) |
| "To assess the validity of the perceptions that appetite-suppressant drugs are ineffective, potentially addictive, and fraught with side effects, we reviewed the effectiveness and safety of two such drugs with purported low abuse potential in the treatment of obesity: mazindol and fenfluramine hydrochloride." | 8.78 | An overview of the efficacy and safety of fenfluramine and mazindol in the treatment of obesity. ( Imperiale, TF; Stahl, KA, 1993) |
| "The chronic ingestion of fenfluramine results in a sustained depression in body weight despite the return of ad libitum food intake to normal levels." | 8.78 | Metabolic consequences of fenfluramine for the control of body weight. ( Levitsky, DA; Troiano, R, 1992) |
| " The aim of the study was to compare the effects of 14 day subcutaneous infusion of the 5-HT(2C) receptor agonists, m-chlorophenylpiperazine (mCPP, 12 mg kg(-1) day(-1)) and Ro 60-0175 (36 mg kg(-1) day(-1)) and the 5-HT releasing agent and re-uptake inhibitor, d-fenfluramine (6 mg kg(-1) day(-1)), on food and water intake, body weight gain and locomotion in lean male Lister hooded rats." | 7.70 | Comparative effects of continuous infusion of mCPP, Ro 60-0175 and d-fenfluramine on food intake, water intake, body weight and locomotor activity in rats. ( Benwell, KR; Bickerdike, MJ; Dourish, CT; Kennett, GA; Porter, RH; Vickers, SP, 2000) |
| "Fenfluramine suppressess the body weight of experimental animals during chronic treatment by a mechanism that is not yet clear." | 7.69 | Chronic fenfluramine treatment: effects on body weight, food intake and energy expenditure. ( Levitsky, DA; Stallone, DD, 1994) |
| "The present experiments describe the effects of continuous SC infusion, via osmotic minipump, of dexfenfluramine on food intake and body weight of male and female rats." | 7.67 | Effect of continuous infusions of dexfenfluramine on food intake, body weight and brain amines in rats. ( Rowland, NE, 1986) |
| "The anorectic effect of CM 57373 in dogs and in rats food-deprived or with experimentally induced hyperphagia (cafeteria-diet hyperphagia and insulin hyperphagia) was compared to the effect of serotoninergic anorectic drug dl-fenfluramine." | 7.67 | Reduction of normal food intake in rats and dogs and inhibition of experimentally induced hyperphagia in rats by CM 57373 and fenfluramine. ( Bianchetti, A; Miranda, GF; Poggesi, E; Samanin, R; Unkovic, J, 1988) |
| "Three experiments have examined the interaction of adrenalectomy and fenfluramine on food intake, body weight and the binding of guanosine-5'-diphosphate (GDP) to interscapular brown adipose tissue (IBAT)." | 7.67 | Interaction of adrenalectomy and fenfluramine treatment on body weight, food intake and brown adipose tissue. ( Arase, K; Bray, GA; Shargill, NS; York, DA, 1989) |
| "The food hoarding behaviour paradigm (HB) was used to evaluate the modification of the set-point of body weight (BW) regulation induced by dexfenfluramine (D-FF) in rats fed with chow or previously made obese by a cafeteria diet for 51 days." | 7.67 | Effect of dexfenfluramine on body weight set-point: study in the rat with hoarding behaviour. ( Faion, F; Fantino, M; Rolland, Y, 1986) |
| "The initial anorexia and development of tolerance to dl-fenfluramine was examined in rats with graded pretreatment body weight losses." | 7.67 | Effects of initial body weight on anorexia and tolerance to fenfluramine in rats. ( Carlton, J; Rowland, N, 1985) |
| " Chronic quipazine treatment had no long-term effect on body weight." | 7.66 | Effect of chronic administration of fenfluramine and quipazine on body weight gain after ovariectomy and on brain serotonin receptor binding. ( Bartness, T; Carlton, J; Rowland, N; Smith, G, 1983) |
| "Dexfenfluramine was well tolerated by the majority of patients." | 6.68 | [Effect of dexfenfluramine on eating behavior and body weight of obese patients: results of a field study of Isomeride in Austrian general practice]. ( Francesconi, M; Geyer, G; Haidinger, G; Kunze, M; Langmayr, N; Prager, R; Schoberberger, R; Toplak, H; von Kalckreuth, G, 1995) |
| "d-Fenfluramine is a 5-HT agonist which decreases food intake and excessive carbohydrate intake in humans." | 6.67 | A placebo-controlled trial of d-fenfluramine in bulimia nervosa. ( Eisler, I; Fahy, TA; Russell, GF, 1993) |
| "d-Fenfluramine (dF) (15 mg twice daily) has been studied in controlled trials in human obesity and has been shown to increase adherence to diet, to enhance its efficacy, and most importantly, to prevent weight regain when continued over 1 y." | 6.17 | Clinical studies with d-fenfluramine. ( Guy-Grand, B, 1992) |
| "D-fenfluramine treatment markedly improved the maximum relaxant response of aortic rings to acetylcholine, indicating improvement of the defective endothelium-derived relaxation factor system." | 5.30 | Improvement of insulin sensitivity and cardiovascular outcomes in the JCR:LA-cp rat by D-fenfluramine. ( Amy, RM; Brindley, DN; Dolphin, PJ; Graham, SE; Russell, JC, 1998) |
| " In the present experiments, we report: (1) the effects of acute administration of dexfenfluramine (DFEN) and PHEN individually and in combination on sweetened milk intake and body weight in non-deprived rats and (2) the effects of chronic administration (7 day minipump) of DFEN, PHEN, and their combination on daily food intake and body weight both during and after the treatment period." | 5.30 | Efficacy of administration of dexfenfluramine and phentermine, alone and in combination, on ingestive behavior and body weight in rats. ( Roth, JD; Rowland, NE, 1998) |
| "of D-fenfluramine were measured over a 5 h period." | 5.29 | Serotonin activity in anorexia nervosa after long-term weight restoration: response to D-fenfluramine challenge. ( Lucey, JV; O'Dwyer, AM; Russell, GF, 1996) |
| "Previous work from this laboratory has shown that chronic administration of dexfenfluramine (DF) caused substantial weight loss in rats that were overweight 3-4 mo after ovariectomy (OVX), but not in OVX rats that were of normal weight, as a result of estrogen replacement." | 5.28 | Dexfenfluramine: action with estradiol on food intake and body weight in ovariectomized rats. ( Rowland, NE; Souquet, AM, 1990) |
| " In Study 2, 19 men and 23 women took part in a 15-week weight loss program that consisted of drug therapy (fenfluramine, 60 mg/day) or placebo coupled to an energy-restricted diet (-2930 kJ/day)." | 5.09 | Fasting insulin levels influence plasma leptin levels independently from the contribution of adiposity: evidence from both a cross-sectional and an intervention study. ( Alméras, N; Bouchard, C; Després, JP; Doucet, E; Mauriège, P; Richard, D; St-Pierre, S; Tremblay, A, 2000) |
| "The effect of the serotonergic agent dexfenfluramine on weight loss, blood pressure, insulin sensitivity and serum lipid levels was determined in a 3-month randomised, double-blind, placebo controlled parallel design study in 50 obese subjects (body mass index 30-44 kg/m2)." | 5.08 | Effect of dexfenfluramine on body weight, blood pressure, insulin resistance and serum cholesterol in obese individuals. ( Gamble, G; Holdaway, IM; Wallace, E; Westbrooke, L, 1995) |
| "3 ng/mL, means +/- SE), the clinical and metabolic effects of benfluorex (B), a lipid-lowering drug able to improve insulin sensitivity." | 5.08 | Benfluorex in obese noninsulin dependent diabetes mellitus patients poorly controlled by insulin: a double blind study versus placebo. ( Camisasca, R; Cassisa, C; Pacchioni, M; Piatti, PM; Pontiroli, AE; Pozza, G, 1996) |
| "Dexfenfluramine lowers body weight in obese patients with upper and lower body obesity and reduces the cardiovascular risk factors clustering in upper body obesity." | 5.08 | The effects of dexfenfluramine on weight loss and cardiovascular risk factors in female patients with upper and lower body obesity. ( Adler, G; Ditschuneit, HH; Flechtner-Mors, M, 1996) |
| "To identify parameters predictive of weight loss during treatment with d-fenfluramine." | 5.08 | Predictors of weight loss during treatment with d-fenfluramine. ( Hopman, E; Meinders, AE; Pijl, H; Toornvliet, AC; Westendorp, RG, 1997) |
| "For patients with bulimia nervosa, the fenfluramine-stimulated increase in serum prolactin concentration was significantly less than for controls." | 5.08 | Decreased serotonin function in bulimia nervosa. ( Cooper, TB; Finkelstein, DM; Jimerson, DC; Levine, JM; Metzger, ED; Wolfe, BE, 1997) |
| "The aim of this work was to investigate the long-term changes of body weight and cardiovascular risk factors after weight reduction with dexfenfluramine (dF) compared to placebo (pI) and additional group therapy." | 5.07 | Long-term changes of body weight and cardiovascular risk factors after weight reduction with group therapy and dexfenfluramine. ( Blomberg, I; Luft, D; Pfohl, M; Schmülling, RM, 1994) |
| "The effects of the serotonergic agent d,l-fenfluramine (60 mg PO) or a placebo on serum prolactin (PRL) and cortisol levels were evaluated in seven patients (five men and two women) with seasonal affective disorders (SAD) and in eight normal controls (eight men and two women)." | 5.07 | Abnormal serotonergic control of prolactin and cortisol secretion in patients with seasonal affective disorder. ( Caffarra, P; Caffarri, G; Chiodera, P; Coiro, V; Davoli, C; Davolio, M; De Ferri, A; Marchesi, C; Rossi, G; Volpi, R, 1993) |
| "The purpose of this study was to determine the effects of dexfenfluramine on body weight and post-prandial thermogenesis in obese subjects." | 5.07 | Effects of dexfenfluramine treatment on body weight and postprandial thermogenesis in obese subjects. A double-blind placebo-controlled study. ( Lafreniere, F; Lambert, J; Rasio, E; Serri, O, 1993) |
| "To assess the effect of dexfenfluramine on weight loss, diabetic control and blood lipids in type II diabetics over a three-month period." | 5.07 | Dexfenfluramine in type II diabetes: effect on weight and diabetes control. ( Davis, TM; Findlater, P; Stein, GR; Stewart, GO, 1993) |
| " Pharmacological treatment of obesity has evolved in recent years with the development and licensing of potent serotonin agonists, such as dexfenfluramine (D-F)." | 5.07 | Body weight evolution during dexfenfluramine treatment after initial weight control. ( Finer, N, 1992) |
| "The effect of dexfenfluramine (dF) on body weight, blood pressure and noradrenergic activity were studied in 30 obese hypertensive patients randomly divided into two groups and treated for 3 months either with dF (30 mg daily; 16 subjects) or placebo (Pl; 14 subjects)." | 5.07 | Effect of dexfenfluramine treatment on body weight, blood pressure and noradrenergic activity in obese hypertensive patients. ( Detry, JM; Kolanowski, J; Vanbutsele, R; Younis, LT, 1992) |
| "We report a 12 month double-blind randomized crossover trial of fenfluramine in 20 children with the syndrome of autism." | 5.06 | A controlled crossover trial of fenfluramine in autism. ( Badcock, NR; Oades, RD; Sawyer, MG; Spence, JG; Stern, LM; Walker, MK, 1990) |
| "A double blind trial was conducted to determine the effect of fenfluramine on the weight and behaviour of patients with the Prader-Willi syndrome." | 5.06 | Fenfluramine in Prader-Willi syndrome: a double blind, placebo controlled trial. ( Pendergast, A; Selikowitz, M; Sunman, J; Wright, S, 1990) |
| "A double-blind, placebo-controlled trial of d-fenfluramine in bulimia nervosa was undertaken in order to assess its efficacy in controlling bulimic behavior and relieving more general symptoms." | 5.06 | A controlled trial of d-fenfluramine in bulimia nervosa. ( Checkley, SA; Eisler, I; Feldman, J; Russell, GF, 1988) |
| "We studied platelet alpha-adrenergic receptor concentration and function in 19 subjects with simple obesity participating in a double-blind, controlled clinical trial of diet and anorexiants (phentermine, fenfluramine, or a combination of the two) or placebo." | 5.05 | Platelet alpha-adrenergic receptors in obesity: alteration with weight loss. ( Banerjee, SP; Hasday, JD; Hershey, LA; Kroening, BH; Sundaresan, PR; Weintraub, M, 1983) |
| "Fenfluramine was administered to 14 outpatient children with the syndrome of autism to determine whether previously produced decreases in blood serotonin concentrations and clinical improvements could be reinstituted." | 5.05 | Study of fenfluramine in outpatients with the syndrome of autism. ( Freeman, BJ; Geller, E; Novak, P; Ritvo, ER; Schroth, P; Yokota, A; Yuwiler, A, 1984) |
| "Fifty women with refractory obesity received fenfluramine for 20 weeks." | 5.04 | Plasma fenfluramine levels, weight loss, and side effects. ( Campbell, DB; Ford, MJ; Innes, JA; Munro, JF; Stoddart, ME; Watson, ML, 1977) |
| "The widely prescribed appetite suppressants D-fenfluramine and fluoxetine not only decrease feeding and body weight but also increase extracellular brain 5-HT." | 4.79 | Appetite suppression by commonly used drugs depends on 5-HT receptors but not on 5-HT availability. ( Curzon, G; Gibson, EL; Oluyomi, AO, 1997) |
| "Controlled studies have shown that sibutramine produces dose-related weight loss when given in the range 5-30 mg per day, with optimal doses of 10 and 15 mg per day." | 4.79 | Sibutramine--a review of clinical efficacy. ( Lean, ME, 1997) |
| "Reports dealing with long-term effects of fenfluramines on brain serotonin neurons, body weight, and pulmonary function in animals and humans." | 4.79 | Brain serotonin neurotoxicity and primary pulmonary hypertension from fenfluramine and dexfenfluramine. A systematic review of the evidence. ( McCann, UD; Ricaurte, GA; Rubin, LJ; Seiden, LS, 1997) |
| "To assess the validity of the perceptions that appetite-suppressant drugs are ineffective, potentially addictive, and fraught with side effects, we reviewed the effectiveness and safety of two such drugs with purported low abuse potential in the treatment of obesity: mazindol and fenfluramine hydrochloride." | 4.78 | An overview of the efficacy and safety of fenfluramine and mazindol in the treatment of obesity. ( Imperiale, TF; Stahl, KA, 1993) |
| "D-Fenfluramine is a potent stimulator of thermogenesis in the rat, an action which may contribute to its effects on body weight." | 4.78 | Thermogenesis, brown adipose tissue and dexfenfluramine in animal studies. ( Le Feuvre, RA; Rothwell, NJ, 1992) |
| "Various animal models of hyperphagia and obesity have made possible the study of the effect on food intake of dexfenfluramine, an agent which both inhibits reuptake and stimulates release of 5 HT." | 4.77 | [Serotonin, food intake and body weight]. ( Rowland, NE; Souquet, AM, 1989) |
| " Body weight, insulin, and leptin were decreased (p < 0." | 3.76 | MR molecular imaging of aortic angiogenesis. ( Cai, K; Caruthers, SD; Huang, W; Lanza, GM; Wickline, SA; Williams, TA; Winter, PM; Zhang, H, 2010) |
| "Both mCPP and d-fenfluramine reduced body weight relative to vehicle-treated controls over the 28-day period." | 3.72 | Oral administration of the 5-HT2Creceptor agonist, mCPP, reduces body weight gain in rats over 28 days as a result of maintained hypophagia. ( Bickerdike, MJ; Dourish, CT; Easton, N; Kennett, GA; Vickers, SP; Webster, LJ; Wyatt, A, 2003) |
| "The mechanisms by which fenfluramine suppresses food intake and body weight have been linked to its ability to enhance transmission across serotonin synapses in brain." | 3.71 | Intermittent, chronic fenfluramine administration to rats repeatedly suppresses food intake despite substantial brain serotonin reductions. ( Choi, S; Fernstrom, JD; Jonak, EM; Patil, V; Simpson, L, 2002) |
| "It has been reported that benfluorex ameliorates the insulin resistance induced by high-fat feeding when its administration is initiated at the same time as the change in diet." | 3.70 | Benfluorex improves muscle insulin responsiveness in middle-aged rats previously subjected to long-term high-fat feeding. ( Gumà, A; Muñoz, P; Palacín, M; Sevilla, L; Testar, X; Zorzano, A, 1999) |
| " The aim of the study was to compare the effects of 14 day subcutaneous infusion of the 5-HT(2C) receptor agonists, m-chlorophenylpiperazine (mCPP, 12 mg kg(-1) day(-1)) and Ro 60-0175 (36 mg kg(-1) day(-1)) and the 5-HT releasing agent and re-uptake inhibitor, d-fenfluramine (6 mg kg(-1) day(-1)), on food and water intake, body weight gain and locomotion in lean male Lister hooded rats." | 3.70 | Comparative effects of continuous infusion of mCPP, Ro 60-0175 and d-fenfluramine on food intake, water intake, body weight and locomotor activity in rats. ( Benwell, KR; Bickerdike, MJ; Dourish, CT; Kennett, GA; Porter, RH; Vickers, SP, 2000) |
| " Dexfenfluramine (dF), a serotonin releaser and reuptake inhibitor, was used to investigate changes in food intake, body weight development, energy expenditure, respiratory quotient, and substrate oxidation rates for 12 days." | 3.69 | Energy expenditure and substrate oxidation rates of obese rats during a 12-day treatment with dexfenfluramine. ( Aust, L; Boschmann, M; Frenz, U; Noack, R, 1996) |
| "This study evaluated the long-term efficacy and safety of the combination of phentermine and fenfluramine for the treatment of obesity in a private practice setting." | 3.69 | Long-term drug treatment of obesity in a private practice setting. ( Atkinson, RL; Blank, RC; Dhurandhar, NV; Ritch, DL; Schumacher, D, 1997) |
| "We determined the effects of D-fenfluramine treatment on the changes in vascular reactivity induced by aging." | 3.68 | Effect of aging and drug-induced weight reduction on rat vascular reactivity. ( Boulanger, M; Duhault, J; Feletou, M; Moreau, N, 1993) |
| " Treatment once a day for 14 days with 25 mg benfluorex per kg body weight lowered body weight, decreased circulating insulin and resulted in an increase in hepatic glycogen." | 3.68 | Effects of chronic benfluorex treatment on the activities of key enzymes of hepatic carbohydrate metabolism in old Sprague-Dawley rats. ( Geelen, MJ; Schmitz, MG; Tielens, AG; van den Heuvel, JM, 1993) |
| "To understand some of the mechanisms underlying the neuroendocrine and neurochemical changes associated with aging, we administered the serotonin [5-hydroxytryptamine (5-HT)] releaser and reuptake inhibitor d-fenfluramine (d-FEN; 0." | 3.68 | Neuroendocrine and neurochemical responses to novelty stress in young and old male F344 rats: effects of d-fenfluramine treatment. ( Burgess, LH; Cabrera, TM; Campbell, DB; Cross, MK; George, M; Gordon, BH; Handa, RJ; Hata, N; Lorens, SA, 1993) |
| "The effects of stress, dexfenfluramine (d-Fen), and a combination of both were investigated on ingestive behavior, body weight, and the humoral immune response in the rat." | 3.68 | Stress and dexfenfluramine: effects on the immune response and energy balance in the rat. ( Fantino, M; Souquet, AM, 1993) |
| "Dexfenfluramine (DFEN) was infused SC at doses of either 6 or 12 mg/kg/day during the last week of pregnancy in rats." | 3.68 | Administration of dexfenfluramine in pregnant rats: effect on brain serotonin parameters in offspring. ( Robertson, RM; Rowland, NE, 1992) |
| "Rats of the JCR:LA-corpulent strain were treated with benfluorex daily at a dose of 25 mg/kg body weight." | 3.68 | Decreased serum lipids, serum insulin and triacylglycerol synthesis in adipose tissue of JCR:LA-corpulent rats treated with benfluorex. ( al-Sieni, AI; Brindley, DN; Hales, P; Russell, JC, 1991) |
| "Food intake, diet selection and body weight gain were examined in three separate experiments in which rats received saline or one of three serotonergic agonists, dexfenfluramine, RU 24969 and fluoxetine." | 3.68 | Effects of repeated administration of serotonergic agonists on diet selection and body weight in rats. ( Li, ET; Luo, SQ, 1991) |
| "Recent studies suggest that dexfenfluramine (D-fenfluramine), because of its pure serotonergic effect, may be a more potent anti-obesity agent, associated with fewer side-effects than the racemate DL-fenfluramine." | 3.68 | Effect of dexfenfluramine on gastric emptying of a mixed solid-liquid meal in obese subjects. ( Chatterton, B; Horowitz, M; Maddox, A; Shearman, D; Vernon-Roberts, J; Wishart, J, 1990) |
| "The present experiments describe the effects of continuous SC infusion, via osmotic minipump, of dexfenfluramine on food intake and body weight of male and female rats." | 3.67 | Effect of continuous infusions of dexfenfluramine on food intake, body weight and brain amines in rats. ( Rowland, NE, 1986) |
| "The anorectic effect of CM 57373 in dogs and in rats food-deprived or with experimentally induced hyperphagia (cafeteria-diet hyperphagia and insulin hyperphagia) was compared to the effect of serotoninergic anorectic drug dl-fenfluramine." | 3.67 | Reduction of normal food intake in rats and dogs and inhibition of experimentally induced hyperphagia in rats by CM 57373 and fenfluramine. ( Bianchetti, A; Miranda, GF; Poggesi, E; Samanin, R; Unkovic, J, 1988) |
| "Three experiments have examined the interaction of adrenalectomy and fenfluramine on food intake, body weight and the binding of guanosine-5'-diphosphate (GDP) to interscapular brown adipose tissue (IBAT)." | 3.67 | Interaction of adrenalectomy and fenfluramine treatment on body weight, food intake and brown adipose tissue. ( Arase, K; Bray, GA; Shargill, NS; York, DA, 1989) |
| "In order to test the hypothesis of Levitzky that d-fenfluramine (d-F) acts by modifying the ponderal set-point, we compared the effects of a permanent infusion of d-F on food intake and body weight (BW)." | 3.67 | Permanent administration of d-fenfluramine in rats: paradoxical effects. ( Apfelbaum, M; Baigts, F; Betoulle, D; Fricker, J; Fumeron, F; Mandenoff, A; Rozen, R, 1988) |
| "Following approximately a week of daily ingestion of fenfluramine, the body weight of female rats is reduced and remains chronically suppressed for as long as treatment is continued." | 3.67 | Enhancement of the thermic effect of food by d-fenfluramine. ( Levitsky, DA; Stallone, D, 1988) |
| "(1) Rats were fed on diets enriched with sucrose, beef tallow or corn oil and treated for 11-16 days with 50 mg of benfluorex per kg of body weight." | 3.67 | Effects of chronic administration of benfluorex to rats on the metabolism of corticosterone, glucose, triacylglycerols, glycerol and fatty acid. ( Akester, H; Brindley, DN; Derrick, GP; Finnerty, C; Irvine, CD; Macdonald, IA; Patmore, RD; Saxton, J; Spencer, H; Yule-Smith, A, 1988) |
| "The food hoarding behaviour paradigm (HB) was used to evaluate the modification of the set-point of body weight (BW) regulation induced by dexfenfluramine (D-FF) in rats fed with chow or previously made obese by a cafeteria diet for 51 days." | 3.67 | Effect of dexfenfluramine on body weight set-point: study in the rat with hoarding behaviour. ( Faion, F; Fantino, M; Rolland, Y, 1986) |
| " Chronic quipazine treatment had no long-term effect on body weight." | 3.66 | Effect of chronic administration of fenfluramine and quipazine on body weight gain after ovariectomy and on brain serotonin receptor binding. ( Bartness, T; Carlton, J; Rowland, N; Smith, G, 1983) |
| "A comparison has been made of the effects of d(+) fenfluramine, Mazindol and Diethylpropion on the changes in body weight and brain ascorbic acid concentrations in male and female guinea pigs receiving vitamin C-deficient diet daily with or without daily supplementary vitamin C for 24 days." | 3.66 | Vitamin C and weight reducing drugs on brain ascorbic acid in guinea pigs. ( Odumosu, A, 1981) |
| "Hydrochlorothiazide, a drug which is often initially prescribed for mild to moderate hypertension, failed to lower blood pressures in 9 of 43 patients but concomitantly elevated plasma norepinephrine (NE) levels in all patients with hypertension." | 3.66 | Fenfluramine potentiation of antihypertensive effects of thiazides. ( Coleman, MD; Kopin, IJ; Lake, CR; Ziegler, MG, 1980) |
| "N-(2-Benzoyloxyethyl) norfenfluramine (S-780) was administered to rats by stomach tube at a dose of 50 mg kg-1 of body weight." | 3.65 | The effects of administering N-(2-benzoyloxyethyl) norfenfluramine to rats on the hepatic synthesis of glycerolipids. ( Boucrot, P; Bowley, M; Brindley, DN; Burditt, S; Lloyd-Davies, KA; Pritchard, H, 1976) |
| "003 to 3 milligrams per kilogram of body weight, failed to maintain self-injection behavior in rhesus monkeys that had initiated and maintained responding for cocaine or methohexital." | 3.65 | Fenfluramine: amphetamine congener that fails to maintain drug-taking behavior in the rhesus monkey. ( Tessel, RE; Woods, JH, 1974) |
| "Measures of subjective feeling used by five patients indicated that depression of mood occurred about four days after fenfluramine withdrawal." | 3.65 | Drugs of dependence though not of abuse: fenfluramine and imipramine. ( Brezinova, V; Briggs, M; Dunleavy, DL; Lewis, SA; Oswald, I, 1971) |
| "Benfluorex + insulin is a valid alternative for obese patients who remain poorly controlled despite insulin or who require high doses of insulin." | 2.69 | Added benfluorex in obese insulin-requiring type 2 diabetes. ( Bauduceau, B; Brun, JM; Guillon-Metz, F; Leutenegger, M; Martin, C; Nicolino-Peltier, C; Richard, JL; Vannereau, D, 1998) |
| "Dexfenfluramine was well tolerated by the majority of patients." | 2.68 | [Effect of dexfenfluramine on eating behavior and body weight of obese patients: results of a field study of Isomeride in Austrian general practice]. ( Francesconi, M; Geyer, G; Haidinger, G; Kunze, M; Langmayr, N; Prager, R; Schoberberger, R; Toplak, H; von Kalckreuth, G, 1995) |
| "d-Fenfluramine is a 5-HT agonist which decreases food intake and excessive carbohydrate intake in humans." | 2.67 | A placebo-controlled trial of d-fenfluramine in bulimia nervosa. ( Eisler, I; Fahy, TA; Russell, GF, 1993) |
| " Dosing changes were based on an algorithm that aimed to achieve 120% of ideal body weight (IBW) while minimizing adverse effects." | 2.67 | Long-term weight control study. III (weeks 104 to 156). An open-label study of dose adjustment of fenfluramine and phentermine. ( Moscucci, M; Schuster, B; Stein, EC; Sundaresan, PR; Weintraub, M, 1992) |
| " The conclusion is therefore that dF possesses no significant thermogenic effect during long-term administration in human obese subjects." | 2.67 | The effect of long-term dexfenfluramine treatment on 24-hour energy expenditure in man. A double-blind placebo controlled study. ( Andersen, T; Astrup, A; Breum, L; Garby, L; Lammert, O; Nielsen, E; Quaade, F, 1990) |
| "Fenfluramine-treated participants reported lower hunger ratings and greater fullness in the target supper-to-bedtime period than participants receiving placebo." | 2.65 | Extended-release fenfluramine: patient acceptance and efficacy of evening dosing. ( Dorn, M; Sriwatanakul, K; Sundaresan, PR; Weintraub, M; Weis, OF, 1983) |
| "The dextroamphetamine group was superior in terms of behavioral treatment participation, extent of eating and exercise habit change, and weight loss." | 2.65 | Double-blind evaluation of reinforcing and anorectic actions of weight control medications. Interaction of pharmacological and behavioral treatments. ( Bigelow, GE; Griffiths, RR; Kaliszak, JE; Liebson, I, 1980) |
| " There was also a significant reduction in plasma dopamine beta-hydroxylase activity during fenfluramine treatment, suggesting that chronic administration may induce antiadrenergic effects which may be useful in the treatment of disorders affected by circulating catecholamines." | 2.64 | Reduction in plasma norepinephrine during fenfluramine treatment. ( de la Vega, CE; Lake, CR; Murphy, DL; Slater, S; Ziegler, MG, 1977) |
| "Fenfluramine was particularly effective in alleviating anxiety in patients who were initially higher in anxiety." | 2.64 | Emotional symptomatology in obese patients treated with fenfluramine and dextroamphetamine. ( Fisher, E; Hesbacher, P; Perloff, MM; Rickels, K; Rosenfeld, H, 1976) |
| " In some patients, weight regain may be prevented by giving the drug long term but the complications of long-term administration have yet to be evaluated." | 2.37 | The current status of antiobesity drugs. ( Farquhar, DL; Galloway, SM; Munro, JF, 1984) |
| "Corticosterone levels were increased in methamphetamine-, fenfluramine-, methylenedioxymethamphetamine- and methylphenidate-treated rats relative to levels in saline-treated rats, whereas cocaine-treated rats were unaffected." | 1.33 | Comparison of monoamine and corticosterone levels 24 h following (+)methamphetamine, (+/-)3,4-methylenedioxymethamphetamine, cocaine, (+)fenfluramine or (+/-)methylphenidate administration in the neonatal rat. ( Ehrman, LA; Gudelsky, GA; Schaefer, TL; Vorhees, CV; Williams, MT, 2006) |
| " dosing for measurement of obesity-related parameters." | 1.32 | Antiobesity effects of A-331440, a novel non-imidazole histamine H3 receptor antagonist. ( Bennani, YL; Bush, EN; Esbenshade, TA; Faghih, R; Fox, GB; Hancock, AA; Jacobson, P; Knourek-Segel, V; Krueger, KM; Nuss, ME; Pan, JB; Shapiro, R; Witte, DG; Yao, BB, 2004) |
| "Fenfluramine (FEN) is a substituted amphetamine known for its anorectic effects, without the stimulatory or abuse potential associated with other amphetamine derivatives." | 1.32 | Metyrapone attenuates the sequential learning deficits but not monoamine depletions following d,l-fenfluramine administration to adult rats. ( Blankenmeyer, TL; Brown-Strittholt, CA; Gudelsky, GA; Skelton, MR; Vorhees, CV; Williams, MT, 2004) |
| "2 times the equivalent human daily dosage according to body surface area." | 1.31 | Impact of antenatal exposure of mice to fenfluramine on cardiac development and long-term growth of the offspring. ( Christensen, HD; Gonzalez, CL; Kupiec, TC; Paulsen, AL; Rayburn, WF; Sienko, AE; Stewart, JD, 2000) |
| "D-fenfluramine treatment markedly improved the maximum relaxant response of aortic rings to acetylcholine, indicating improvement of the defective endothelium-derived relaxation factor system." | 1.30 | Improvement of insulin sensitivity and cardiovascular outcomes in the JCR:LA-cp rat by D-fenfluramine. ( Amy, RM; Brindley, DN; Dolphin, PJ; Graham, SE; Russell, JC, 1998) |
| "Benfluorex-treated animals showed significant decreases in glucose intolerance, hyperinsulinemia, hypertriglyceridemia, hypercholesterolemia, and plasma LDL- and VLDL-cholesterol, with no evidence of aortic atheroma." | 1.30 | Metabolic and anti-atherogenic effects of long-term benfluorex in dyslipidemic insulin-resistant sand rats (Psammomys obesus). ( Bennani, N; El Madani, T; Hadjiisky, P; Marquié, G; Pieraggi, MT; Ravel, D; Seguin, L; Solera, ML, 1998) |
| " PHEN also significantly enhanced FEN's long-term toxic effects on 5-HT axons." | 1.30 | Neurotoxic effects of +/-fenfluramine and phenteramine, alone and in combination, on monoamine neurons in the mouse brain. ( McCann, UD; Ricaurte, GA; Yuan, J, 1998) |
| " At 1 and 2 weeks after the 4 d dosing regimen, acute FEN (1." | 1.30 | Functional consequences of central serotonin depletion produced by repeated fenfluramine administration in rats. ( Ayestas, MA; Baumann, MH; Rothman, RB, 1998) |
| ") 2 h after Fen application, a strong synergism could be seen in the late treatment period as shown by the dose-response curves and by statistical analysis using the principle of least squares." | 1.29 | Potentiation by caffeine of the frequencies of chromosomal aberrations induced by chronic exposure to fenfluramine in mice. ( Agarwal, K; Mukherjee, A; Sen, S; Sharma, A, 1994) |
| " Young male rats were dosed with AFB or vehicle alone and were then assigned to receive control diet (NO FEN) or control diet + FEN (FEN; 0." | 1.29 | The effects of D-fenfluramine on the development of aflatoxin-B1 induced GGT+ hepatic foci in F344 rats. ( Bell, RC; Campbell, TC; Levitsky, DA, 1993) |
| "of D-fenfluramine were measured over a 5 h period." | 1.29 | Serotonin activity in anorexia nervosa after long-term weight restoration: response to D-fenfluramine challenge. ( Lucey, JV; O'Dwyer, AM; Russell, GF, 1996) |
| "Benfluorex treatment and pair feeding decreased serum triacylglycerol concentrations by about 50%; there was a preferential loss of triacylglycerols containing longer chain fatty acids in the males, whereas this selectivity was not seen in the females." | 1.29 | Effects of benfluorex on serum triacylglycerols and insulin sensitivity in the corpulent rat. ( Brindley, DN; Dolphin, PJ; Graham, SE; Russell, JC, 1996) |
| "Fenfluramine is an amphetamine derivative which is used as a weight-reducing agent in the treatment of obesity." | 1.28 | Role for brain corticotropin-releasing factor in the weight-reducing effects of chronic fenfluramine treatment in rats. ( Appel, NM; Bissette, G; Contrera, JF; Culp, S; De Souza, EB; Nemeroff, CB; Owens, MJ; Zaczek, R, 1991) |
| "3." | 1.27 | Effect of three anorectic drugs on central catecholamine levels and synthesis in the Zucker rat. ( Bremond, J; Cohen, Y; Jacquot, C; Orosco, M, 1983) |
| "Body weight was reduced 2-4 weeks after fenfluramine injection in 1 week old animals; however 2 week animals showed only a small transient reduction during the first week following fenfluramine." | 1.27 | Biochemical and functional effects of fenfluramine in maturing mice. ( Baker, PC; Bauman, GP; Goodrich, CA, 1986) |
| "d-Fenfluramine was equally effective against the hyperphagia and weight gain induced by either fat or CHO supplements." | 1.27 | Do serotoninergic drugs decrease energy intake by reducing fat or carbohydrate intake? Effect of d-fenfluramine with supplemented weight-increasing diets. ( Blundell, JE; Hill, AJ, 1988) |
| "Fenfluramine-treated rats had lower body weights in both chronic experiments even after food intake returned to normal." | 1.27 | Lateral hypothalamic lesions and fenfluramine increase thermogenesis in brown adipose tissue. ( Bray, GA; Groos, E; Kemnitz, JW; Lupien, JR; Tokunaga, K, 1986) |
| " In a dose-response study there was no significant increase with doses of 2 or 6 mg/kg but there was a significant increase at 20 mg/kg." | 1.27 | Effect of fenfluramine on GDP-binding to brown adipose tissue mitochondria. ( Bray, GA; Lupien, JR, 1985) |
| " There was a strong correlation between drug dosage and plasma levels of fenfluramine." | 1.26 | Plasma fenfluramine levels, weight loss and side effects: a failure to find a relationship. ( Brownell, K; Campbell, DB; Pietrusko, R; Stunkard, A, 1982) |
| "The problem of obesity is not well dealt with in the ordinary diabetes clinic." | 1.25 | A year's experience in a clinic for obese diabetics. ( Goldblatt, R; Jackson, WP; Movsowitz, F, 1975) |
| "Grinding of teeth (bruxism) also was noted." | 1.25 | Chronic fenfluramine administration: some cerebral effects. ( Dunleavy, DL; Lewis, SA; Oswald, I, 1971) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 171 (57.97) | 18.7374 |
| 1990's | 98 (33.22) | 18.2507 |
| 2000's | 22 (7.46) | 29.6817 |
| 2010's | 4 (1.36) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cox, MT | 1 |
| Jaggers, SE | 1 |
| Jones, G | 1 |
| Carmody, JS | 1 |
| Ahmad, NN | 1 |
| Machineni, S | 1 |
| Lajoie, S | 1 |
| Kaplan, LM | 1 |
| Martin-Gronert, MS | 1 |
| Stocker, CJ | 1 |
| Wargent, ET | 1 |
| Cripps, RL | 1 |
| Garfield, AS | 1 |
| Jovanovic, Z | 1 |
| D'Agostino, G | 1 |
| Yeo, GS | 1 |
| Cawthorne, MA | 1 |
| Arch, JR | 1 |
| Heisler, LK | 1 |
| Ozanne, SE | 1 |
| Pringle, A | 1 |
| Jennings, KA | 1 |
| Line, S | 1 |
| Bannerman, DM | 1 |
| Higgs, S | 1 |
| Sharp, T | 1 |
| Li, JX | 1 |
| Koek, W | 1 |
| France, CP | 1 |
| Cai, K | 1 |
| Caruthers, SD | 1 |
| Huang, W | 1 |
| Williams, TA | 1 |
| Zhang, H | 1 |
| Wickline, SA | 1 |
| Lanza, GM | 1 |
| Winter, PM | 1 |
| Vorhees, CV | 4 |
| He, E | 1 |
| Skelton, MR | 2 |
| Graham, DL | 1 |
| Schaefer, TL | 2 |
| Grace, CE | 1 |
| Braun, AA | 1 |
| Amos-Kroohs, R | 1 |
| Williams, MT | 4 |
| Morford, LL | 1 |
| Inman-Wood, SL | 1 |
| Gudelsky, GA | 3 |
| Vickers, SP | 2 |
| Easton, N | 1 |
| Webster, LJ | 1 |
| Wyatt, A | 1 |
| Bickerdike, MJ | 2 |
| Dourish, CT | 2 |
| Kennett, GA | 2 |
| Wellman, PJ | 2 |
| Jones, SL | 1 |
| Miller, DK | 1 |
| Hancock, AA | 1 |
| Bennani, YL | 1 |
| Bush, EN | 2 |
| Esbenshade, TA | 1 |
| Faghih, R | 1 |
| Fox, GB | 1 |
| Jacobson, P | 1 |
| Knourek-Segel, V | 2 |
| Krueger, KM | 1 |
| Nuss, ME | 1 |
| Pan, JB | 1 |
| Shapiro, R | 2 |
| Witte, DG | 1 |
| Yao, BB | 1 |
| Blankenmeyer, TL | 1 |
| Brown-Strittholt, CA | 1 |
| van der Stelt, HM | 1 |
| Breuer, ME | 1 |
| Olivier, B | 1 |
| Westenberg, HG | 1 |
| Choi, S | 3 |
| Blake, V | 1 |
| Cole, S | 1 |
| Fernstrom, JD | 3 |
| Ehrman, LA | 1 |
| Nonogaki, K | 1 |
| Nozue, K | 1 |
| Oka, Y | 1 |
| Souers, AJ | 1 |
| Iyengar, RR | 1 |
| Judd, AS | 1 |
| Beno, DW | 1 |
| Gao, J | 1 |
| Zhao, G | 1 |
| Brune, ME | 1 |
| Napier, JJ | 1 |
| Mulhern, MM | 1 |
| Lynch, JK | 1 |
| Freeman, JC | 1 |
| Wodka, D | 1 |
| Chen, CJ | 1 |
| Falls, HD | 1 |
| Brodjian, S | 1 |
| Dayton, BD | 1 |
| Diaz, GJ | 1 |
| Droz, BA | 1 |
| Hernandez, LE | 1 |
| Marsh, KC | 1 |
| Reilly, RM | 1 |
| Sham, HL | 1 |
| Collins, CA | 1 |
| Kym, PR | 1 |
| Evenden, J | 1 |
| Ko, T | 1 |
| Voigt, JP | 2 |
| Raasch, W | 1 |
| Hörtnagl, H | 1 |
| Bader, M | 1 |
| Fink, H | 2 |
| Jöhren, O | 1 |
| Stunkard, AJ | 7 |
| Craighead, LW | 2 |
| O'Brien, R | 1 |
| Blundell, JE | 6 |
| Tombros, E | 1 |
| Rogers, PJ | 1 |
| Latham, CJ | 1 |
| Douglas, JG | 1 |
| Gough, J | 1 |
| Preston, PG | 2 |
| Frazer, I | 1 |
| Haslett, C | 1 |
| Chalmers, SR | 1 |
| Munro, JF | 6 |
| Orosco, M | 2 |
| Bremond, J | 2 |
| Jacquot, C | 2 |
| Cohen, Y | 2 |
| Harsing, LG | 1 |
| Yang, HY | 1 |
| Govoni, S | 1 |
| Costa, E | 1 |
| Sundaresan, PR | 6 |
| Weintraub, M | 8 |
| Hershey, LA | 1 |
| Kroening, BH | 1 |
| Hasday, JD | 2 |
| Banerjee, SP | 1 |
| Sriwatanakul, K | 1 |
| Weis, OF | 1 |
| Dorn, M | 1 |
| Stunkard, A | 3 |
| Mushlin, AI | 1 |
| Lockwood, DH | 1 |
| Galloway, SM | 1 |
| Farquhar, DL | 1 |
| Ritvo, ER | 1 |
| Freeman, BJ | 1 |
| Yuwiler, A | 1 |
| Geller, E | 1 |
| Yokota, A | 1 |
| Schroth, P | 1 |
| Novak, P | 1 |
| Klingberg, H | 1 |
| Klingberg, F | 1 |
| Köllner, O | 1 |
| Kästner, I | 1 |
| Verdy, M | 1 |
| Charbonneau, L | 1 |
| Verdy, I | 1 |
| Belanger, R | 1 |
| Bolte, E | 1 |
| Chiasson, JL | 1 |
| Rowland, N | 3 |
| Carlton, J | 6 |
| Bartness, T | 1 |
| Smith, G | 1 |
| Brownell, KD | 3 |
| Hunsinger, RN | 4 |
| Barnes, TB | 1 |
| Kapeghian, JC | 1 |
| Wilson, MC | 3 |
| Wilson, M | 1 |
| Hill, DT | 1 |
| Stanley, KG | 1 |
| Williams, JE | 1 |
| Loev, B | 1 |
| Fowler, PJ | 1 |
| McCafferty, JP | 1 |
| Macko, E | 2 |
| Berkoff, CE | 1 |
| Ladd, CB | 1 |
| Bigelow, GE | 2 |
| Griffiths, RR | 2 |
| Liebson, I | 2 |
| Kaliszak, JE | 1 |
| Misra, NP | 1 |
| Bhambal, SA | 1 |
| Yesikar, SS | 1 |
| Bellani, RK | 1 |
| Pasquine, TA | 1 |
| Thenen, SW | 2 |
| Magnoni, V | 1 |
| Boni, S | 1 |
| Bonini, LM | 1 |
| Zecca, L | 1 |
| Bareggi, SR | 1 |
| Guagnano, MT | 2 |
| Di Vincenzo, M | 1 |
| Sensi, S | 2 |
| Antelman, SM | 1 |
| Kocan, D | 1 |
| Pietrusko, R | 1 |
| Brownell, K | 1 |
| Campbell, DB | 4 |
| Bermann, MC | 1 |
| Berthelot, P | 1 |
| Bonte, JP | 1 |
| Debaert, M | 1 |
| Lesieur, D | 1 |
| Brunet, C | 1 |
| Cazin, M | 1 |
| Lesieur, I | 1 |
| Luyckx, M | 1 |
| Cazin, JC | 1 |
| Levitsky, DA | 7 |
| Strupp, BJ | 2 |
| Lupoli, J | 1 |
| O'Brien, RM | 1 |
| Leshem, M | 1 |
| Odumosu, A | 4 |
| Salomon, R | 1 |
| Behar, L | 1 |
| Lake, CR | 2 |
| Ziegler, MG | 2 |
| Coleman, MD | 1 |
| Kopin, IJ | 1 |
| Wales, JK | 1 |
| Glikmanas, M | 1 |
| McCann, UD | 3 |
| Yuan, J | 2 |
| Ricaurte, GA | 3 |
| Li, BH | 1 |
| Rowland, NE | 13 |
| Feletou, M | 1 |
| Moreau, N | 1 |
| Boulanger, M | 1 |
| Duhault, J | 2 |
| Bell, RC | 2 |
| Lanou, AJ | 1 |
| Frongillo, EA | 1 |
| Campbell, TC | 2 |
| O'Shea, RD | 1 |
| Gundlach, AL | 1 |
| Stallone, DD | 1 |
| Khan, M | 1 |
| Lum, CT | 1 |
| Rao, V | 1 |
| Richter-Levin, G | 1 |
| Greenberger, V | 1 |
| Segal, M | 1 |
| Boschmann, M | 3 |
| Frenz, U | 3 |
| Noack, R | 3 |
| Aust, L | 2 |
| Murphy, CM | 2 |
| Sen, S | 1 |
| Agarwal, K | 1 |
| Mukherjee, A | 1 |
| Sharma, A | 1 |
| Pfohl, M | 1 |
| Luft, D | 1 |
| Blomberg, I | 1 |
| Schmülling, RM | 1 |
| Kogon, MM | 1 |
| Kräuchi, K | 1 |
| Van der Velde, P | 1 |
| Van der Werf, H | 1 |
| Keller, U | 1 |
| Rieg, TS | 1 |
| Maestrello, AM | 1 |
| Aravich, PF | 1 |
| Mathus-Vliegen, EM | 1 |
| Stahl, KA | 1 |
| Imperiale, TF | 1 |
| Fletcher, PJ | 1 |
| Currie, PJ | 1 |
| Chambers, JW | 1 |
| Coscina, DV | 1 |
| Coiro, V | 1 |
| Volpi, R | 1 |
| Marchesi, C | 1 |
| De Ferri, A | 1 |
| Davoli, C | 1 |
| Caffarra, P | 1 |
| Rossi, G | 1 |
| Caffarri, G | 1 |
| Davolio, M | 1 |
| Chiodera, P | 1 |
| Solyom, L | 1 |
| Fahy, TA | 1 |
| Eisler, I | 2 |
| Russell, GF | 3 |
| Tielens, AG | 1 |
| van den Heuvel, JM | 1 |
| Schmitz, MG | 1 |
| Geelen, MJ | 1 |
| Lee, S | 1 |
| Chan, K | 1 |
| Handa, RJ | 1 |
| Cross, MK | 1 |
| George, M | 1 |
| Gordon, BH | 1 |
| Burgess, LH | 1 |
| Cabrera, TM | 1 |
| Hata, N | 1 |
| Lorens, SA | 1 |
| Souquet, AM | 3 |
| Fantino, M | 4 |
| Dotson, LM | 1 |
| Lafreniere, F | 1 |
| Lambert, J | 1 |
| Rasio, E | 2 |
| Serri, O | 2 |
| Berlin, I | 1 |
| Puech, AJ | 1 |
| Stewart, GO | 1 |
| Stein, GR | 1 |
| Davis, TM | 1 |
| Findlater, P | 1 |
| Benthem, L | 1 |
| Scheurink, AJ | 1 |
| Van der Leest, J | 1 |
| Leuvenink, H | 1 |
| Zijlstra, WG | 1 |
| Steffens, AB | 1 |
| Holdaway, IM | 1 |
| Wallace, E | 1 |
| Westbrooke, L | 1 |
| Gamble, G | 1 |
| Geyer, G | 1 |
| Haidinger, G | 1 |
| Francesconi, M | 1 |
| Langmayr, N | 1 |
| Prager, R | 1 |
| Schoberberger, R | 1 |
| Toplak, H | 1 |
| von Kalckreuth, G | 1 |
| Kunze, M | 1 |
| O'Dwyer, AM | 1 |
| Lucey, JV | 1 |
| Sonka, J | 1 |
| Marek, J | 1 |
| Svacina, S | 1 |
| Sucharda, P | 1 |
| Stĕpán, J | 1 |
| Jordaan, GP | 1 |
| Roberts, MC | 1 |
| Emsley, RA | 1 |
| Malone, KM | 1 |
| Corbitt, EM | 1 |
| Li, S | 1 |
| Mann, JJ | 1 |
| Pontiroli, AE | 1 |
| Pacchioni, M | 1 |
| Piatti, PM | 1 |
| Cassisa, C | 1 |
| Camisasca, R | 1 |
| Pozza, G | 1 |
| Ditschuneit, HH | 1 |
| Flechtner-Mors, M | 1 |
| Adler, G | 1 |
| Russell, JC | 4 |
| Graham, SE | 2 |
| Dolphin, PJ | 2 |
| Brindley, DN | 8 |
| Desta, B | 1 |
| Schultz, D | 1 |
| Ravel, D | 2 |
| Laudignon, N | 1 |
| Vanhoutte, PM | 1 |
| Boulanger, CM | 1 |
| Monego, ET | 1 |
| Peixoto, Mdo R | 1 |
| Jardim, PC | 1 |
| Sousa, AL | 1 |
| Braga, VL | 1 |
| Moura, MF | 1 |
| Cerda, JJ | 1 |
| Curzon, G | 1 |
| Gibson, EL | 1 |
| Oluyomi, AO | 1 |
| Lean, ME | 1 |
| Toornvliet, AC | 1 |
| Pijl, H | 1 |
| Hopman, E | 1 |
| Westendorp, RG | 1 |
| Meinders, AE | 1 |
| Jimerson, DC | 1 |
| Wolfe, BE | 1 |
| Metzger, ED | 1 |
| Finkelstein, DM | 1 |
| Cooper, TB | 1 |
| Levine, JM | 1 |
| Caccia, S | 1 |
| Confalonieri, S | 1 |
| Bergami, A | 1 |
| Fracasso, C | 1 |
| Anelli, M | 1 |
| Garattini, S | 1 |
| Seiden, LS | 1 |
| Rubin, LJ | 1 |
| Fields, M | 1 |
| Lewis, CG | 1 |
| Atkinson, RL | 1 |
| Blank, RC | 1 |
| Schumacher, D | 1 |
| Dhurandhar, NV | 1 |
| Ritch, DL | 1 |
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| Hindmarsh, JG | 1 |
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| Cozzi, NV | 1 |
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| Marona-Lewicka, D | 1 |
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| Nichols, DE | 1 |
| Leutenegger, M | 1 |
| Bauduceau, B | 1 |
| Brun, JM | 2 |
| Guillon-Metz, F | 1 |
| Martin, C | 1 |
| Nicolino-Peltier, C | 1 |
| Richard, JL | 1 |
| Vannereau, D | 1 |
| Halladay, AK | 1 |
| Fisher, H | 1 |
| Wagner, GC | 1 |
| Amy, RM | 1 |
| Roth, JD | 1 |
| Lucas, JJ | 1 |
| Yamamoto, A | 1 |
| Scearce-Levie, K | 1 |
| Saudou, F | 1 |
| Hen, R | 1 |
| Marquié, G | 1 |
| El Madani, T | 1 |
| Solera, ML | 1 |
| Pieraggi, MT | 1 |
| Hadjiisky, P | 1 |
| Seguin, L | 1 |
| Bennani, N | 1 |
| Baumann, MH | 1 |
| Ayestas, MA | 1 |
| Rothman, RB | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Abdominal Obesity as a Therapeutic Target: Long-term Benefits of Abdominal Fat Loss and Weight Stabilization in High-risk Abdominally Obese Dyslipidemic Patients With the Features of the Metabolic Syndrome (SYNERGIE Study)[NCT06158191] | 186 participants (Actual) | Interventional | 2004-03-26 | Completed | |||
| [NCT00000506] | Phase 2 | 0 participants | Interventional | 1983-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
20 reviews available for fenfluramine and Body Weight
| Article | Year |
|---|---|
The development of tolerance to drugs that suppress food intake.
Topics: Animals; Appetite Depressants; Body Weight; Cyclobutanes; Drug Tolerance; Eating; Fenfluramine; Huma | 2008 |
The current status of antiobesity drugs.
Topics: Adult; Amphetamine; Appetite Depressants; Body Weight; Child; Diethylpropion; Dose-Response Relation | 1984 |
Anorectic agents lower a body weight set point.
Topics: Animals; Appetite Depressants; Appetite Regulation; Behavior Therapy; Body Weight; Dextroamphetamine | 1982 |
An overview of the efficacy and safety of fenfluramine and mazindol in the treatment of obesity.
Topics: Adult; Body Weight; Clinical Trials as Topic; Double-Blind Method; Female; Fenfluramine; Humans; Mal | 1993 |
Appetite suppression by commonly used drugs depends on 5-HT receptors but not on 5-HT availability.
Topics: Appetite Depressants; Body Weight; Brain; Dopamine Agonists; Eating; Female; Fenfluramine; Fluoxetin | 1997 |
Sibutramine--a review of clinical efficacy.
Topics: Anti-Obesity Agents; Antidepressive Agents; Appetite Depressants; Body Weight; Cardiovascular Physio | 1997 |
Brain serotonin neurotoxicity and primary pulmonary hypertension from fenfluramine and dexfenfluramine. A systematic review of the evidence.
Topics: Animals; Appetite Depressants; Axons; Body Weight; Brain; Brain Chemistry; Fenfluramine; Humans; Hyp | 1997 |
Synergistic interactions between fenfluramine and phentermine.
Topics: Animals; Appetite; Appetite Depressants; Body Weight; Brain; Drug Synergism; Drug Therapy, Combinati | 1999 |
Thermogenesis, brown adipose tissue and dexfenfluramine in animal studies.
Topics: Adipose Tissue, Brown; Animals; Body Temperature Regulation; Body Weight; Energy Metabolism; Fenflur | 1992 |
Metabolic consequences of fenfluramine for the control of body weight.
Topics: Adipose Tissue, Brown; Animals; Body Temperature Regulation; Body Weight; Energy Metabolism; Fenflur | 1992 |
Clinical studies with d-fenfluramine.
Topics: Body Weight; Female; Fenfluramine; Humans; Obesity | 1992 |
Tolerance to fenfluramine anorexia: fact or fiction?
Topics: Animals; Behavior Therapy; Body Weight; Brain; Brain Chemistry; Drug Tolerance; Feeding Behavior; Fe | 1986 |
[Serotonin, food intake and body weight].
Topics: Animals; Body Weight; Disease Models, Animal; Eating; Feeding Behavior; Fenfluramine; Humans; Hyperp | 1989 |
Direct and indirect thermogenic effects of anorectic drugs.
Topics: Adipose Tissue, Brown; Amphetamine; Animals; Appetite Depressants; Body Temperature Regulation; Body | 1985 |
Pharmacological treatments that affect CNS activity: serotonin.
Topics: Animals; Antidepressive Agents; Body Weight; Compulsive Behavior; Eating; Energy Intake; Feeding and | 1987 |
Neurobiology of an anorectic drug: fenfluramine.
Topics: Acute Disease; Adipose Tissue; Animals; Anorexia; Arousal; Avoidance Learning; Behavior Therapy; Bod | 1986 |
Clinical use of appetite suppressants.
Topics: Amphetamines; Appetite Depressants; Body Weight; Diethylpropion; Double-Blind Method; Drug Tolerance | 1986 |
[Drug-induced phospholipid storage disease].
Topics: Adrenal Gland Diseases; Amitriptyline; Animals; Anticholesteremic Agents; Appetite Depressants; Body | 1973 |
[Obesity-background and treatment].
Topics: Age Factors; Amphetamine; Appetite Regulation; Body Weight; Diet, Reducing; Fatty Acids; Female; Fen | 1972 |
The management of obesity.
Topics: Adolescent; Adult; Amphetamine; Body Weight; Child; Chlorphentermine; Diet, Reducing; Diethylpropion | 1972 |
77 trials available for fenfluramine and Body Weight
| Article | Year |
|---|---|
Controlled trial of behaviour therapy, pharmacotherapy, and their combination in the treatment of obesity.
Topics: Behavior Therapy; Blood Pressure; Body Weight; Clinical Trials as Topic; Female; Fenfluramine; Human | 1980 |
Long-term efficacy of fenfluramine in treatment of obesity.
Topics: Body Weight; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind Method; Female; Fen | 1983 |
Platelet alpha-adrenergic receptors in obesity: alteration with weight loss.
Topics: Adult; Body Weight; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Female | 1983 |
Extended-release fenfluramine: patient acceptance and efficacy of evening dosing.
Topics: Adolescent; Adult; Behavior Therapy; Body Weight; Clinical Trials as Topic; Delayed-Action Preparati | 1983 |
Drugs and diet therapy.
Topics: Animals; Appetite Depressants; Behavior Therapy; Body Weight; Clinical Trials as Topic; Female; Fenf | 1983 |
A double-blind clinical trial in weight control. Use of fenfluramine and phentermine alone and in combination.
Topics: Adolescent; Adult; Body Weight; Clinical Trials as Topic; Diet; Double-Blind Method; Drug Therapy, C | 1984 |
Study of fenfluramine in outpatients with the syndrome of autism.
Topics: Adolescent; Autistic Disorder; Body Weight; Child; Child Development; Child, Preschool; Female; Fenf | 1984 |
Fenfluramine in the treatment of non-insulin-dependent diabetics: hypoglycemic versus anorectic effect.
Topics: Aged; Appetite Depressants; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Double-Blind Meth | 1983 |
The double-blind in danger: untoward consequences of informed consent.
Topics: Adult; Aged; Body Weight; Clinical Trials as Topic; Dizziness; Double-Blind Method; Fatigue; Female; | 1982 |
Double-blind evaluation of reinforcing and anorectic actions of weight control medications. Interaction of pharmacological and behavioral treatments.
Topics: Adult; Behavior Therapy; Body Weight; Clinical Trials as Topic; Dextroamphetamine; Double-Blind Meth | 1980 |
Behavior therapy and pharmacotherapy for obesity.
Topics: Adult; Aged; Behavior Therapy; Body Weight; Female; Fenfluramine; Humans; Male; Middle Aged; Obesity | 1981 |
Long-term changes of body weight and cardiovascular risk factors after weight reduction with group therapy and dexfenfluramine.
Topics: Adult; Blood Glucose; Body Mass Index; Body Weight; Cardiovascular Diseases; Cholesterol; Female; Fe | 1994 |
Psychological and metabolic effects of dietary carbohydrates and dexfenfluramine during a low-energy diet in obese women.
Topics: Adult; Affect; Blood Pressure; Body Weight; Diet, Reducing; Dietary Carbohydrates; Energy Intake; En | 1994 |
Prolonged surveillance of dexfenfluramine in severe obesity.
Topics: Adult; Body Weight; Double-Blind Method; Female; Fenfluramine; Follow-Up Studies; Humans; Male; Obes | 1993 |
Abnormal serotonergic control of prolactin and cortisol secretion in patients with seasonal affective disorder.
Topics: Adult; Body Weight; Female; Fenfluramine; Humans; Hydrocortisone; Male; Prolactin; Seasonal Affectiv | 1993 |
A placebo-controlled trial of d-fenfluramine in bulimia nervosa.
Topics: Adolescent; Adult; Body Weight; Bulimia; Cognitive Behavioral Therapy; Combined Modality Therapy; Fe | 1993 |
Effects of dexfenfluramine treatment on body weight and postprandial thermogenesis in obese subjects. A double-blind placebo-controlled study.
Topics: Adult; Blood Chemical Analysis; Body Temperature; Body Weight; Calorimetry, Indirect; Double-Blind M | 1993 |
Dexfenfluramine in type II diabetes: effect on weight and diabetes control.
Topics: Adult; Aged; Blood Glucose; Body Weight; Cholesterol; Diabetes Mellitus; Diabetes Mellitus, Type 2; | 1993 |
Effect of dexfenfluramine on body weight, blood pressure, insulin resistance and serum cholesterol in obese individuals.
Topics: Adult; Blood Pressure; Body Mass Index; Body Weight; Cholesterol; Dose-Response Relationship, Drug; | 1995 |
[Effect of dexfenfluramine on eating behavior and body weight of obese patients: results of a field study of Isomeride in Austrian general practice].
Topics: Adult; Aged; Appetite Depressants; Austria; Body Weight; Combined Modality Therapy; Diet, Reducing; | 1995 |
Benfluorex in obese noninsulin dependent diabetes mellitus patients poorly controlled by insulin: a double blind study versus placebo.
Topics: 3-Hydroxybutyric Acid; Appetite Depressants; Body Weight; C-Peptide; Diabetes Mellitus; Diabetes Mel | 1996 |
The effects of dexfenfluramine on weight loss and cardiovascular risk factors in female patients with upper and lower body obesity.
Topics: Adult; Analysis of Variance; Appetite Depressants; Body Mass Index; Body Weight; Cardiovascular Dise | 1996 |
[Different therapies in the treatment of obesity in hypertensive patients].
Topics: Adult; Aged; Blood Pressure; Body Mass Index; Body Weight; Diet, Fat-Restricted; Double-Blind Method | 1996 |
Predictors of weight loss during treatment with d-fenfluramine.
Topics: Adult; Analysis of Variance; Appetite Depressants; Body Weight; Energy Intake; Female; Fenfluramine; | 1997 |
Decreased serotonin function in bulimia nervosa.
Topics: Adult; Body Weight; Bulimia; Cross-Sectional Studies; Dose-Response Relationship, Drug; Female; Fenf | 1997 |
Added benfluorex in obese insulin-requiring type 2 diabetes.
Topics: Adolescent; Adult; Aged; Blood Glucose; Body Weight; C-Peptide; Diabetes Mellitus; Diabetes Mellitus | 1998 |
Gender difference in the effect of body composition on energy metabolism.
Topics: Abdomen; Adipose Tissue; Adult; Appetite Depressants; Basal Metabolism; Body Composition; Body Weigh | 1999 |
Neurohormonal responses to D-fenfluramine in healthy elderly subjects. A placebo-controlled study.
Topics: Aged; Aged, 80 and over; Aging; Behavior; Body Weight; Female; Fenfluramine; Hemodynamics; Humans; H | 2000 |
Fasting insulin levels influence plasma leptin levels independently from the contribution of adiposity: evidence from both a cross-sectional and an intervention study.
Topics: Adipose Tissue; Adult; Body Composition; Body Weight; Cross-Sectional Studies; Diet, Reducing; Energ | 2000 |
Reduction of visceral adipose tissue during weight loss.
Topics: Adipose Tissue; Adult; Analysis of Variance; Body Weight; Diet, Reducing; Double-Blind Method; Femal | 2002 |
Letter: Peripheral effects of anorectic drugs.
Topics: Body Weight; Female; Fenfluramine; Humans; Male; Obesity; Placebos | 1976 |
Reduction in plasma norepinephrine during fenfluramine treatment.
Topics: Adult; Blood Pressure; Body Weight; Clinical Trials as Topic; Depression; Depression, Chemical; Dopa | 1977 |
Metabolic effects of fenfluramine in obese diabetics.
Topics: Aged; Blood Glucose; Body Weight; Cholesterol; Clinical Trials as Topic; Diabetes Mellitus; Female; | 1977 |
Fenfluramine, vitamin C and weight loss.
Topics: Administration, Oral; Ascorbic Acid; Body Weight; Clinical Trials as Topic; Diet, Reducing; Double-B | 1978 |
Plasma fenfluramine levels, weight loss, and side effects.
Topics: Adult; Aged; Body Weight; Female; Fenfluramine; Humans; Middle Aged; Norfenfluramine; Obesity | 1977 |
Metabolic effects of fenfluramine--a double-blind study.
Topics: Adult; Basal Metabolism; Body Weight; Clinical Trials as Topic; Diet, Reducing; Female; Fenfluramine | 1975 |
A clinical trial of a new fenfluramine preparation (Ponderax PA).
Topics: Blood Pressure; Body Weight; Clinical Trials as Topic; Delayed-Action Preparations; Female; Fenflura | 1975 |
A comparison of the efficacy and acceptability of fenfluramine tablets (BP) and prolonged action capsules.
Topics: Blood Pressure; Body Weight; Clinical Trials as Topic; Delayed-Action Preparations; Female; Fenflura | 1975 |
The effect of fenfluramine on obesity and plasma lipids of patients with renal allografts.
Topics: Body Weight; Clinical Trials as Topic; Female; Fenfluramine; Humans; Hypercholesterolemia; Kidney Tr | 1975 |
Subjective effects of two anorexigenic agents--fenfluramine and AN 448 in normal subjects.
Topics: Appetite; Appetite Depressants; Attention; Blood Pressure; Body Weight; Clinical Trials as Topic; Em | 1975 |
Emotional symptomatology in obese patients treated with fenfluramine and dextroamphetamine.
Topics: Adult; Anxiety; Body Weight; Clinical Trials as Topic; Depression; Dextroamphetamine; Emotions; Fema | 1976 |
Anorectic effectiveness of various dosages of fenfluramine and placebo: a cooperative study.
Topics: Adult; Appetite Depressants; Body Weight; Clinical Trials as Topic; Drug Administration Schedule; Dr | 1975 |
[Glucose tolerance, insulin and lipids after one week's administration of fenfluramine to overweight patients (author's transl)].
Topics: Adult; Blood Glucose; Body Weight; Cholesterol; Fatty Acids, Nonesterified; Fenfluramine; Glucose To | 1975 |
Anorectic effectiveness of differing dosage forms of fenfluramine.
Topics: Adolescent; Adult; Aged; Appetite; Blood Pressure; Body Weight; Clinical Trials as Topic; Dosage For | 1976 |
Fenfluramine in man: hypophagia associated with diminished serotonin turnover.
Topics: Adult; Appetite; Body Weight; Clinical Trials as Topic; Depression, Chemical; Dopamine; Feeding and | 1975 |
Behavioural and biochemical effects of fenfluramine in patients with neurologic disease.
Topics: Adult; Behavior; Body Weight; Female; Fenfluramine; Humans; Male; Middle Aged; Nervous System Diseas | 1975 |
A trial of fenfluramine (PACaps) and diet in overweight diabetic patients.
Topics: Body Weight; Diabetes Mellitus; Diet, Reducing; Fenfluramine; Humans; Obesity | 1975 |
Body weight evolution during dexfenfluramine treatment after initial weight control.
Topics: Adult; Body Weight; Diet, Reducing; Double-Blind Method; Energy Intake; Female; Fenfluramine; Humans | 1992 |
[Antidiabetic efficacy of benfluorex. Clinical data].
Topics: Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Female; Fenfluramine; Humans; Hypolipidemic A | 1992 |
Long-term weight control study. I (weeks 0 to 34). The enhancement of behavior modification, caloric restriction, and exercise by fenfluramine plus phentermine versus placebo.
Topics: Adult; Behavior Therapy; Blood Pressure; Body Weight; Diet, Reducing; Double-Blind Method; Exercise; | 1992 |
Long-term weight control study. III (weeks 104 to 156). An open-label study of dose adjustment of fenfluramine and phentermine.
Topics: Adult; Blood Pressure; Body Weight; Dose-Response Relationship, Drug; Drug Therapy, Combination; Fem | 1992 |
Long-term weight control study. IV (weeks 156 to 190). The second double-blind phase.
Topics: Adult; Behavior Therapy; Body Weight; Diet, Reducing; Double-Blind Method; Drug Therapy, Combination | 1992 |
Long-term weight control study. V (weeks 190 to 210). Follow-up of participants after cessation of medication.
Topics: Adult; Behavior Therapy; Body Weight; Diet, Reducing; Double-Blind Method; Drug Therapy, Combination | 1992 |
Long-term weight control study: conclusions.
Topics: Adult; Body Weight; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Diet, Reducing; Drug Therapy, C | 1992 |
Effect of dexfenfluramine treatment on body weight, blood pressure and noradrenergic activity in obese hypertensive patients.
Topics: Adult; Blood Pressure; Body Weight; Catecholamines; Double-Blind Method; Exercise; Female; Fenfluram | 1992 |
Clinical studies with d-fenfluramine.
Topics: Body Weight; Female; Fenfluramine; Humans; Obesity | 1992 |
A controlled crossover trial of fenfluramine in autism.
Topics: Adolescent; Arousal; Autistic Disorder; Body Weight; Child; Child, Preschool; Double-Blind Method; F | 1990 |
The effect of long-term dexfenfluramine treatment on 24-hour energy expenditure in man. A double-blind placebo controlled study.
Topics: Adult; Body Temperature; Body Weight; Calorimetry; Clinical Trials as Topic; Double-Blind Method; En | 1990 |
Fenfluramine in Prader-Willi syndrome: a double blind, placebo controlled trial.
Topics: Adolescent; Adult; Body Weight; Child; Child Behavior; Child, Preschool; Double-Blind Method; Female | 1990 |
A controlled trial of d-fenfluramine in bulimia nervosa.
Topics: Adolescent; Adult; Anorexia Nervosa; Attitude; Body Weight; Bulimia; Clinical Trials as Topic; Depre | 1988 |
Treatment of bulimia with fenfluramine and desipramine.
Topics: Adolescent; Adult; Body Weight; Bulimia; Clinical Trials as Topic; Depression; Desipramine; Double-B | 1988 |
Effects of benfluorex on patients with endogenous hypertriglyceridaemia.
Topics: Adult; Aged; Body Weight; Double-Blind Method; Female; Fenfluramine; Humans; Hyperlipidemias; Hypoli | 1987 |
Fenfluramine in the treatment of obesity.
Topics: Adult; Appetite Depressants; Body Weight; Clinical Trials as Topic; Constipation; Dextroamphetamine; | 1973 |
Effects of caloric restriction and fenfluramine on weight loss and personality profiles of patients with long standing obesity.
Topics: Adolescent; Adult; Aged; Body Weight; Clinical Trials as Topic; Diet, Reducing; Drug Tolerance; Feed | 1973 |
Fenfluramine in obese patients on various antihypertensive drugs. Double-blind controlled trial.
Topics: Antihypertensive Agents; Appetite Depressants; Blood Glucose; Blood Pressure; Body Weight; Cholester | 1969 |
Comparison of fenfluramine and metformin in treatment of obesity.
Topics: Adult; Appetite Depressants; Body Weight; Clinical Trials as Topic; Female; Fenfluramine; Fluorine; | 1970 |
Circulatory effects of fenfluramine in obese hypertensive patients.
Topics: Blood Pressure; Body Weight; Cardiac Output; Clinical Trials as Topic; Female; Fenfluramine; Heart R | 1974 |
A double-blind clinical trial of fenfluramine.
Topics: Appetite Regulation; Blood Pressure; Body Height; Body Weight; Clinical Trials as Topic; Diarrhea; F | 1972 |
A double-blind clinical trial of fenfluramine in the treatment of obesity.
Topics: Adolescent; Adult; Age Factors; Body Weight; Child; Clinical Trials as Topic; Female; Fenfluramine; | 1973 |
Treatment of obesity with fenfluramine.
Topics: Adolescent; Adult; Blood Glucose; Blood Pressure; Body Weight; Cholesterol; Clinical Trials as Topic | 1973 |
Fenfluramine in corticosteroid-induced obesity.
Topics: Adult; Appetite; Asthma; Blood Pressure; Body Weight; Chronic Disease; Clinical Trials as Topic; Fem | 1972 |
[Treatment of obesity with fenfluramine (Ponderal)].
Topics: Adolescent; Adult; Blood Glucose; Body Weight; Cholesterol; Clinical Trials as Topic; Depression, Ch | 1973 |
The metabolic effects, and the composition of the tissue lost, in weight reduction by obese patients on treatment with fenfluramine.
Topics: Adipose Tissue; Adult; Body Composition; Body Weight; Clinical Trials as Topic; Densitometry; Diet, | 1973 |
Comparison of a new anorectic agent AN 448 with fenfluramine in the treatment of refractory obesity.
Topics: Adult; Appetite Depressants; Body Weight; Clinical Trials as Topic; Female; Fenfluramine; Humans; Im | 1974 |
Fenfluramine (Ponderax) in the treatment of obese psychiatric out-patients.
Topics: Anxiety Disorders; Appetite Depressants; Body Weight; Clinical Trials as Topic; Depression; Diarrhea | 1969 |
[Administration of fenfluramine in double blind trial in patients with exogenous obesity. Analysis of therapeutic results and effects on lipid metabolism].
Topics: Appetite Depressants; Body Weight; Clinical Trials as Topic; Fenfluramine; Humans; Lipid Metabolism; | 1971 |
A collaborative investigation of fenfluramine. Anorexigenic with sedative properties.
Topics: Adult; Appetite Depressants; Body Weight; Clinical Trials as Topic; Female; Fenfluramine; Fluorine; | 1970 |
199 other studies available for fenfluramine and Body Weight
| Article | Year |
|---|---|
Linked Aryl Aryloxypropanolamines as a new class of lipid catabolis agents.
Topics: Adipose Tissue; Animals; Appetite Depressants; Body Weight; Dogs; Eating; Female; Lipid Metabolism; | 1978 |
Weight Loss After RYGB Is Independent of and Complementary to Serotonin 2C Receptor Signaling in Male Mice.
Topics: Animals; Blood Glucose; Body Weight; Feeding Behavior; Fenfluramine; Gastric Bypass; Male; Mice, Inb | 2015 |
5-HT2A and 5-HT2C receptors as hypothalamic targets of developmental programming in male rats.
Topics: Animals; Animals, Newborn; Arcuate Nucleus of Hypothalamus; Body Weight; Dietary Proteins; Feeding B | 2016 |
Mice overexpressing the 5-hydroxytryptamine transporter show no alterations in feeding behaviour and increased non-feeding responses to fenfluramine.
Topics: Animals; Body Weight; Dose-Response Relationship, Drug; Feeding Behavior; Fenfluramine; Gene Express | 2008 |
Food restriction and streptozotocin differentially modify sensitivity to the hypothermic effects of direct- and indirect-acting serotonin receptor agonists in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Body Temperature; Body Weight; Diet; DOM 2,5-Dimeth | 2009 |
MR molecular imaging of aortic angiogenesis.
Topics: Animals; Aorta; Appetite Depressants; Atherosclerosis; Body Weight; Cholesterol; Disease Models, Ani | 2010 |
Comparison of (+)-methamphetamine, ±-methylenedioxymethamphetamine, (+)-amphetamine and ±-fenfluramine in rats on egocentric learning in the Cincinnati water maze.
Topics: Amphetamine; Analysis of Variance; Animals; Behavior, Animal; Body Temperature; Body Weight; Central | 2011 |
Impaired spatial and sequential learning in rats treated neonatally with D-fenfluramine.
Topics: Animals; Animals, Newborn; Behavior, Animal; Body Weight; Dose-Response Relationship, Drug; Female; | 2002 |
Oral administration of the 5-HT2Creceptor agonist, mCPP, reduces body weight gain in rats over 28 days as a result of maintained hypophagia.
Topics: Administration, Oral; Animals; Body Weight; Dose-Response Relationship, Drug; Drug Administration Ro | 2003 |
Effects of preexposure to dexfenfluramine, phentermine, dexfenfluramine-phentermine, or fluoxetine on sibutramine-induced hypophagia in the adult rat.
Topics: Animals; Antidepressive Agents, Second-Generation; Appetite Depressants; Body Weight; Cyclobutanes; | 2003 |
Antiobesity effects of A-331440, a novel non-imidazole histamine H3 receptor antagonist.
Topics: Adipose Tissue; Animals; Anti-Obesity Agents; Appetite Depressants; Behavior, Animal; Biphenyl Compo | 2004 |
Metyrapone attenuates the sequential learning deficits but not monoamine depletions following d,l-fenfluramine administration to adult rats.
Topics: Adrenal Glands; Age Factors; Animals; Biogenic Monoamines; Body Temperature; Body Weight; Enzyme Inh | 2004 |
Permanent deficits in serotonergic functioning of olfactory bulbectomized rats: an in vivo microdialysis study.
Topics: Animals; Area Under Curve; Behavior, Animal; Body Weight; Brain; Brain Chemistry; Chromatography, Hi | 2005 |
Effects of chronic fenfluramine administration on hypothalamic neuropeptide mRNA expression.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Behavior, Animal; Body Weight; Corticotropin-Releasing Hor | 2006 |
Comparison of monoamine and corticosterone levels 24 h following (+)methamphetamine, (+/-)3,4-methylenedioxymethamphetamine, cocaine, (+)fenfluramine or (+/-)methylphenidate administration in the neonatal rat.
Topics: 3,4-Methylenedioxyamphetamine; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Bi | 2006 |
Hyperphagia alters expression of hypothalamic 5-HT2C and 5-HT1B receptor genes and plasma des-acyl ghrelin levels in Ay mice.
Topics: Agouti Signaling Protein; Animals; Blood Glucose; Body Weight; Caloric Restriction; Eating; Fenflura | 2006 |
Constrained 7-fluorocarboxychromone-4-aminopiperidine based Melanin-concentrating hormone receptor 1 antagonists: the effects of chirality on substituted indan-1-ylamines.
Topics: Animals; Anti-Obesity Agents; Appetite Depressants; Body Weight; Brain; Cell Line; Chromones; Diet; | 2007 |
The effects of anorexic drugs on free-fed rats responding under a second-order FI15-min (FR10:S) schedule for high incentive foods.
Topics: Animals; Appetite; Appetite Depressants; Appetitive Behavior; Body Weight; Dextroamphetamine; Dose-R | 2007 |
Changes in the brain serotonin satiety system in transgenic rats lacking brain angiotensinogen.
Topics: Angiotensinogen; Animals; Animals, Genetically Modified; Body Weight; Brain; Cerebral Cortex; Eating | 2008 |
Behavioural analysis of feeding: implications for the pharmacological manipulation of food intake in animals and man.
Topics: Amphetamine; Animals; Antipsychotic Agents; Appetite Depressants; Body Weight; Eating; Feeding Behav | 1980 |
Fenfluramine and brain transmitters in the obese Zucker rat.
Topics: Animals; Body Weight; Brain Chemistry; Catecholamines; Dopamine; Feeding Behavior; Female; Fenfluram | 1984 |
Elevation of Met5-enkephalin and beta-endorphin hypothalamic content in rats receiving anorectic drugs: differences between D-fenfluramine and D-amphetamine.
Topics: Animals; beta-Endorphin; Body Weight; Brain; Dextroamphetamine; Endorphins; Enkephalin, Methionine; | 1982 |
Unique applications of fenfluramine or p-chloramphetamine in the early postnatal period influence the formation of conditioned avoidance responses in adult rats.
Topics: Amphetamines; Analgesia; Animals; Animals, Newborn; Avoidance Learning; Body Weight; Fenfluramine; F | 1983 |
Effect of chronic administration of fenfluramine and quipazine on body weight gain after ovariectomy and on brain serotonin receptor binding.
Topics: Animals; Appetite; Body Weight; Brain; Castration; Female; Fenfluramine; Muridae; Quinolines; Quipaz | 1983 |
Alteration of the disruptive effect of fenfluramine on food consumption in the rat by repeated post-session administration of d-amphetamine.
Topics: Animals; Body Weight; Dextroamphetamine; Drug Interactions; Drug Tolerance; Feeding Behavior; Fenflu | 1981 |
Anorectic agents and the set point theory for regulation of body weight.
Topics: Animals; Appetite Depressants; Appetite Regulation; Body Weight; Fenfluramine; Rats | 1983 |
1,3-Diaryltriazenes: a new class of anorectic agents.
Topics: Animals; Appetite Depressants; Body Weight; Dextroamphetamine; Dogs; Dose-Response Relationship, Dru | 1983 |
Effect of three anorectic drugs on central catecholamine levels and synthesis in the Zucker rat.
Topics: alpha-Methyltyrosine; Animals; Appetite Depressants; Body Weight; Brain Chemistry; Catecholamines; D | 1983 |
Fenfluramine in management of obese diabetics.
Topics: Adult; Blood Pressure; Body Weight; Diabetes Mellitus; Drug Synergism; Female; Fenfluramine; Humans; | 1980 |
Fenfluramine effects on insulin resistance and lipogenesis in genetically obese (ob/ob) mice.
Topics: Adipose Tissue; Animals; Blood Glucose; Body Weight; Cells, Cultured; Fatty Acids; Fenfluramine; Ins | 1981 |
[Activity of fenfluramine in obese subjects. Relation between dosage, plasma concentration of the drug and its effect on weight loss].
Topics: Adult; Aged; Body Weight; Dose-Response Relationship, Drug; Female; Fenfluramine; Humans; Male; Midd | 1982 |
[Chronotherapy of obesity. I. Effect of fenfluramine on the decrease of adipose mass in the obese, in relation to the time of administration].
Topics: Adipose Tissue; Adult; Body Weight; Drug Administration Schedule; Female; Fenfluramine; Humans; Male | 1982 |
Differences among 'serotonergic' anorectics in a cross-tolerance paradigm: do they all act on serotonin systems?
Topics: Animals; Appetite Depressants; Body Weight; Drug Tolerance; Fenfluramine; Male; Pyrazines; Quipazine | 1982 |
Plasma fenfluramine levels, weight loss and side effects: a failure to find a relationship.
Topics: Adult; Aged; Behavior Therapy; Body Weight; Female; Fenfluramine; Humans; Middle Aged; Obesity | 1982 |
Chemical and pharmacological studies of anorectic drugs with phenylpiperazinyl structure.
Topics: Amphetamine; Animals; Appetite Depressants; Body Weight; Chemical Phenomena; Chemistry; Drinking; Ea | 1982 |
Tolerance to anorectic drugs: pharmacological or artifactual.
Topics: Amphetamine; Animals; Appetite Depressants; Body Weight; Drug Tolerance; Eating; Female; Fenfluramin | 1981 |
Differential changes in plasma high-density lipoprotein-cholesterol levels in obese men and women during weight reduction.
Topics: Adult; Body Weight; Cholesterol; Female; Fenfluramine; Humans; Lipoproteins; Lipoproteins, HDL; Lipo | 1981 |
Couples training, pharmacotherapy, and behavior therapy in the treatment of obesity.
Topics: Adult; Behavior Therapy; Body Weight; Female; Fenfluramine; Humans; Male; Marital Therapy; Obesity | 1981 |
Ontogeny of fenfluramine and amphetamine anorexia compared in rat pups.
Topics: Aging; Amphetamine; Animals; Body Weight; Dose-Response Relationship, Drug; Eating; Fenfluramine; Mu | 1981 |
Vitamin C and weight reducing drugs on brain ascorbic acid in guinea pigs.
Topics: Animals; Appetite Depressants; Ascorbic Acid; Body Weight; Brain; Diethylpropion; Female; Fenflurami | 1981 |
The effect of halogenated amphetamines on protein synthesis in newborn rats.
Topics: Amphetamines; Animals; Animals, Newborn; Body Weight; Female; Fenfluramine; Methionine; Molecular We | 1980 |
Fenfluramine potentiation of antihypertensive effects of thiazides.
Topics: Antihypertensive Agents; Blood Pressure; Body Weight; Drug Synergism; Drug Therapy, Combination; Fen | 1980 |
The effect of fenfluramine on weight loss during restricted dietary regimes.
Topics: Body Weight; Female; Fenfluramine; Humans; Male; Norfenfluramine; Obesity | 1980 |
[Efficacy of benfluorex in the treatment of multiple metabolic overloads: preliminary results concerning 1609 cases].
Topics: Body Weight; Carbohydrate Metabolism; Fenfluramine; Humans; Hypolipidemic Agents; Lipid Metabolism; | 1980 |
Fenfluramine's appetite suppression and serotonin neurotoxicity are separable.
Topics: Animals; Anorexia; Appetite; Body Weight; Drug Combinations; Eating; Fenfluramine; Fluoxetine; Male; | 1995 |
Effects of vagotomy on cholecystokinin- and dexfenfluramine-induced Fos-like immunoreactivity in the rat brain.
Topics: Animals; Body Weight; Brain Chemistry; Cholecystokinin; Fenfluramine; Immunohistochemistry; Male; Pr | 1995 |
Effect of aging and drug-induced weight reduction on rat vascular reactivity.
Topics: Administration, Oral; Aging; Animals; Aorta; Blood Glucose; Body Weight; Endothelium, Vascular; Fenf | 1993 |
Accuracy and reliability of total body electrical conductivity (TOBEC) for determining body composition of rats in experimental studies.
Topics: Adipose Tissue; Animals; Body Composition; Body Weight; Dose-Response Relationship, Drug; Electric C | 1994 |
Long-term administration of dexfenfluramine to genetically obese (ob/ob) and lean mice: body weight and brain serotonin changes.
Topics: Animals; Blood Glucose; Body Weight; Brain Chemistry; Corticosterone; Dietary Fats; Female; Fenflura | 1994 |
Lack of direct action of D-fenfluramine on arcuate preproNPY mRNA levels in the rat.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Body Weight; Eating; Fenfluramine; Male; Neuropeptide Y; P | 1994 |
Chronic fenfluramine treatment: effects on body weight, food intake and energy expenditure.
Topics: Animals; Body Weight; Dose-Response Relationship, Drug; Eating; Energy Metabolism; Fasting; Fenflura | 1994 |
Successful appetite suppression therapy with fenfluramine and phentermine in the obese diabetic transplant patient.
Topics: Blood Glucose; Body Weight; Diabetes Mellitus; Diabetic Nephropathies; Diet, Reducing; Drug Therapy, | 1995 |
The effects of general and restricted serotonergic lesions on hippocampal electrophysiology and behavior.
Topics: Action Potentials; Animals; Body Weight; Fenfluramine; Hippocampus; Learning; Male; Prosencephalon; | 1994 |
Energy metabolism and metabolite patterns of rats after application of dexfenfluramine.
Topics: Amino Acids; Animals; Blood Glucose; Body Weight; Calorimetry, Indirect; Eating; Energy Metabolism; | 1994 |
Potentiation by caffeine of the frequencies of chromosomal aberrations induced by chronic exposure to fenfluramine in mice.
Topics: Administration, Oral; Animals; Body Weight; Bone Marrow; Caffeine; Chromosome Aberrations; Dose-Resp | 1994 |
Weight cycling alters the effects of D-fenfluramine on susceptibility to activity-based anorexia.
Topics: Animals; Anorexia; Body Weight; Eating; Fenfluramine; Male; Physical Exertion; Rats; Rats, Sprague-D | 1994 |
The effects of D-fenfluramine on the development of aflatoxin-B1 induced GGT+ hepatic foci in F344 rats.
Topics: Adipose Tissue; Aflatoxin B1; Animals; Blood Chemical Analysis; Body Weight; Carrier Proteins; Diet; | 1993 |
Radiofrequency lesions of the PVN fail to modify the effects of serotonergic drugs on food intake.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Body Weight; Clonidine; Feeding Behavior; Fenfluram | 1993 |
Controlling panic attacks with fenfluramine.
Topics: Adolescent; Adult; Body Mass Index; Body Weight; Bulimia; Depressive Disorder; Female; Fenfluramine; | 1994 |
Effects of chronic benfluorex treatment on the activities of key enzymes of hepatic carbohydrate metabolism in old Sprague-Dawley rats.
Topics: Aging; Animals; Body Weight; Fenfluramine; Glucose; Glycogen; Insulin; Liver; Male; Phosphoenolpyruv | 1993 |
d-fenfluramine and cognitive therapy in bulimia nervosa.
Topics: Body Weight; Bulimia; Cognitive Behavioral Therapy; Combined Modality Therapy; Female; Fenfluramine; | 1993 |
Neuroendocrine and neurochemical responses to novelty stress in young and old male F344 rats: effects of d-fenfluramine treatment.
Topics: Adrenocorticotropic Hormone; Aging; Animals; Body Weight; Brain Chemistry; Catecholamines; Corticost | 1993 |
Stress and dexfenfluramine: effects on the immune response and energy balance in the rat.
Topics: Animals; Antibody Formation; Body Weight; Corticosterone; Drinking; Eating; Energy Metabolism; Fenfl | 1993 |
Adrenalectomy enhances the anorectic effect of dexfenfluramine: relation to mineralocorticoids and salt appetite.
Topics: Adrenal Glands; Adrenalectomy; Animals; Appetite; Body Weight; Desoxycorticosterone; Dose-Response R | 1993 |
Is it dexfenfluramine or weight loss that reduces blood pressure and noradrenergic activity in obese patients?
Topics: Blood Pressure; Body Weight; Fenfluramine; Humans; Hypertension; Norepinephrine; Obesity | 1993 |
Effects of long-term d-fenfluramine treatment on energy metabolism in rats.
Topics: Animals; Blood Glucose; Body Weight; Calorimetry; Carbon Dioxide; Dietary Carbohydrates; Dietary Fat | 1993 |
Serotonin activity in anorexia nervosa after long-term weight restoration: response to D-fenfluramine challenge.
Topics: Administration, Oral; Adult; Anorexia Nervosa; Body Weight; Comorbidity; Female; Fenfluramine; Follo | 1996 |
Somatometric and hormonal effects of dexfenfluramine.
Topics: Appetite Depressants; Body Weight; Energy Intake; Female; Fenfluramine; Growth Hormone; Hormones; Hu | 1995 |
Energy expenditure and substrate oxidation rates of obese rats during a 12-day treatment with dexfenfluramine.
Topics: Amino Acids; Animals; Blood Glucose; Body Weight; Calorimetry, Indirect; Dose-Response Relationship, | 1996 |
Serotonergic agents in the treatment of hypothalamic obesity syndrome: a case report.
Topics: Adult; Body Weight; Brain Damage, Chronic; Dose-Response Relationship, Drug; Fenfluramine; Fluoxetin | 1996 |
Prolactin response to fenfluramine and suicide attempt lethality in major depression.
Topics: Adult; Body Weight; Depressive Disorder; Female; Fenfluramine; Humans; Hydrocortisone; Longitudinal | 1996 |
Changes in energy metabolism and metabolite patterns of obese rats after application of dexfenfluramine.
Topics: Animals; Body Weight; Dose-Response Relationship, Drug; Eating; Energy Metabolism; Fenfluramine; Mal | 1996 |
Effects of benfluorex on serum triacylglycerols and insulin sensitivity in the corpulent rat.
Topics: Animals; Body Weight; Disease Models, Animal; Eating; Female; Fenfluramine; Hypolipidemic Agents; In | 1996 |
Acute and chronic effects of dexfenfluramine on the porcine coronary artery.
Topics: Animals; Body Weight; Coronary Vessels; Fenfluramine; In Vitro Techniques; Male; Platelet Aggregatio | 1996 |
The pharmacologic management of obesity.
Topics: Adult; Anti-Obesity Agents; Appetite Depressants; Body Mass Index; Body Weight; Chronic Disease; Fen | 1997 |
Neuropharmacological effects of low and high doses of repeated oral dexfenfluramine in rats: a comparison with fluoxetine.
Topics: Administration, Oral; Animals; Appetite Depressants; Body Weight; Brain Chemistry; Catecholamines; D | 1997 |
Benfluorex, a hypotriglyceridemic drug, reduces lipid peroxidation and alleviates adverse metabolic complications of copper deficiency.
Topics: Amylases; Analysis of Variance; Animals; Body Weight; Cohort Studies; Copper; Diet; Fasting; Fenflur | 1997 |
Long-term drug treatment of obesity in a private practice setting.
Topics: Adolescent; Adult; Appetite Depressants; Blood Glucose; Blood Pressure; Body Mass Index; Body Weight | 1997 |
The effect of fenfluramine dosage regimen and reduced food intake on levels of 5-HT in rat brain.
Topics: Animals; Body Weight; Brain Chemistry; Dose-Response Relationship, Drug; Eating; Fenfluramine; Hydro | 1997 |
Indan analogs of fenfluramine and norfenfluramine have reduced neurotoxic potential.
Topics: Animals; Appetite Depressants; Body Weight; Brain Chemistry; Discrimination, Psychological; Fenflura | 1998 |
Interaction of phentermine plus fenfluramine: neurochemical and neurotoxic effects.
Topics: Adrenergic Agents; Animals; Body Weight; Brain; Central Nervous System Stimulants; Dopamine; Dopamin | 1998 |
Improvement of insulin sensitivity and cardiovascular outcomes in the JCR:LA-cp rat by D-fenfluramine.
Topics: Acetylcholine; Animals; Aorta; Aorta, Thoracic; Aortic Diseases; Appetite Depressants; Arteriosclero | 1998 |
Efficacy of administration of dexfenfluramine and phentermine, alone and in combination, on ingestive behavior and body weight in rats.
Topics: Animals; Appetite Depressants; Body Weight; Drug Synergism; Feeding Behavior; Fenfluramine; Male; Ph | 1998 |
Absence of fenfluramine-induced anorexia and reduced c-Fos induction in the hypothalamus and central amygdaloid complex of serotonin 1B receptor knock-out mice.
Topics: Amygdala; Animals; Anorexia; Appetite Depressants; Body Weight; Drug Evaluation, Preclinical; Feedin | 1998 |
Metabolic and anti-atherogenic effects of long-term benfluorex in dyslipidemic insulin-resistant sand rats (Psammomys obesus).
Topics: Animal Nutritional Physiological Phenomena; Animals; Aorta; Arteriosclerosis; Body Weight; Cholester | 1998 |
Neurotoxic effects of +/-fenfluramine and phenteramine, alone and in combination, on monoamine neurons in the mouse brain.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Appetite Depressants; Biogenic Monoamines; Body Weight; Bra | 1998 |
Functional consequences of central serotonin depletion produced by repeated fenfluramine administration in rats.
Topics: Animals; Behavior, Animal; Body Weight; Brain; Corticosterone; Dose-Response Relationship, Drug; Fen | 1998 |
Benfluorex improves muscle insulin responsiveness in middle-aged rats previously subjected to long-term high-fat feeding.
Topics: Aging; Animals; Biological Transport; Blood Glucose; Blotting, Northern; Body Weight; Deoxyglucose; | 1999 |
Behavioral effects of AR-R 15849, a highly selective CCK-A agonist.
Topics: Animals; Appetite Depressants; Behavior, Animal; Body Weight; Cholecystokinin; Drug Tolerance; Eatin | 1999 |
Effects of antihistamines on fenfluramine-induced depletion of indoles in the brain of rats.
Topics: Animals; Biomarkers; Body Temperature; Body Weight; Brain; Chlorpheniramine; Drug Interactions; Fenf | 1999 |
CRF-deficient mice respond like wild-type mice to hypophagic stimuli.
Topics: Animals; Appetite Depressants; Body Weight; Corticotropin-Releasing Hormone; Cues; Eating; Endotoxin | 1999 |
Effects of fenfluramine on body weight, feed intake, and reproductive activities of broiler breeder hens.
Topics: Adipose Tissue; Aging; Animals; Body Composition; Body Weight; Chickens; Eating; Female; Fenfluramin | 1999 |
Comparative effects of continuous infusion of mCPP, Ro 60-0175 and d-fenfluramine on food intake, water intake, body weight and locomotor activity in rats.
Topics: Analysis of Variance; Animals; Body Weight; Drinking; Eating; Ethylamines; Fenfluramine; Hypothalamu | 2000 |
Impact of antenatal exposure of mice to fenfluramine on cardiac development and long-term growth of the offspring.
Topics: Abnormalities, Drug-Induced; Animals; Animals, Newborn; Aortic Valve; Body Weight; Brain; Dexfenflur | 2000 |
Does increased endogenous CCK interact with serotonin to reduce food intake in rats?
Topics: Animals; Anorexia; Body Weight; Cholecystokinin; Dose-Response Relationship, Drug; Drug Interactions | 2000 |
Intermittent, chronic fenfluramine administration to rats repeatedly suppresses food intake despite substantial brain serotonin reductions.
Topics: 5-Hydroxytryptophan; Animals; Appetite; Body Weight; Brain; Down-Regulation; Drug Administration Sch | 2002 |
The effects of administering N-(2-benzoyloxyethyl) norfenfluramine to rats on the hepatic synthesis of glycerolipids.
Topics: Animals; Body Weight; Diet; Feeding Behavior; Fenfluramine; Glycerol; In Vitro Techniques; Lipids; L | 1976 |
Peripheral effects of anorectic drugs.
Topics: Body Weight; Drug Evaluation; Energy Metabolism; Fenfluramine; Humans | 1976 |
Three anorectic drugs: similar structures but different effects on brain and behavior.
Topics: Amphetamine; Animals; Appetite Depressants; Behavior; Blood Glucose; Body Weight; Brain; Dose-Respon | 1978 |
Therapeutic self-medication as a context for drug abuse research.
Topics: Adult; Body Weight; Dextroamphetamine; Drug Prescriptions; Female; Fenfluramine; Humans; Male; Metha | 1978 |
The effect of 5-hydroxytryptophan on food intake and on the anorexic action of amphetamine and fenfluramine.
Topics: 5-Hydroxytryptophan; Amphetamine; Analysis of Variance; Animals; Appetite; Body Weight; Brain; Fenfl | 1975 |
Effects of prolonged fenfluramine administration in obese and nonobese mice.
Topics: Administration, Oral; Animals; Aurothioglucose; Blood Glucose; Body Composition; Body Weight; Female | 1977 |
Bile acid, neutral sterol and faecal fat excretion in subjects treated with fenfluramine and its relationship to fenfluramine-induced diarrhoea.
Topics: Bile Acids and Salts; Body Weight; Diarrhea; Feces; Fenfluramine; Humans; Lipid Metabolism; Sterols | 1979 |
A three year follow-up of a behavioral treatment for obesity.
Topics: Behavior Therapy; Body Weight; Feeding Behavior; Female; Fenfluramine; Follow-Up Studies; Humans; Ma | 1979 |
Tissue ascorbic acid, fenfluramine, and changes in fat metabolism.
Topics: Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Body Weight; Cholesterol; Disease Models, Animal; | 1979 |
The variable response to fenfluramine in obesity.
Topics: Adult; Body Weight; Female; Fenfluramine; Humans; Middle Aged; Obesity; Patient Compliance | 1979 |
Vitamin C and the anti-obesity effect of fenfluramine.
Topics: Animals; Appetite; Ascorbic Acid; Ascorbic Acid Deficiency; Body Weight; Female; Fenfluramine; Guine | 1979 |
The effects of para-chloroamphetamine on fenfluramine anorexia in ad libitum and stimulation-induced feeding in the rat.
Topics: Amphetamines; Animals; Body Weight; Drug Interactions; Electric Stimulation; Feeding Behavior; Fenfl | 1979 |
Clinical trial of fenfluramine in the treatment of obesity in Thai people.
Topics: Adult; Body Weight; Female; Fenfluramine; Humans; Male; Middle Aged; Obesity; Thailand | 1977 |
Behavioral treatment of obesity: the current status.
Topics: Behavior Therapy; Body Weight; Cues; Dietary Proteins; Eating; Energy Intake; Fasting; Feeding Behav | 1978 |
[Proceedings: Glucose tolerance insulin and lipids following 1 week of fenfluramine administration].
Topics: Body Weight; Fenfluramine; Glucose Tolerance Test; Humans; Insulin; Lipids; Obesity; Time Factors | 1975 |
Long-and short-term regulation of feeding patterns in the rat.
Topics: Animals; Appetite Regulation; Body Weight; Circadian Rhythm; Dextroamphetamine; Feeding Behavior; Fe | 1977 |
The effects of benfluramate on carbohydrate metabolism in obesity.
Topics: Adult; Blood Glucose; Body Weight; Carbohydrate Metabolism; Female; Fenfluramine; Humans; Kinetics; | 1977 |
[Therapy of obesity].
Topics: Adolescent; Adult; Alanine Transaminase; Appetite Depressants; Aspartate Aminotransferases; Body Wei | 1976 |
Tolerance pattern of the anorexigenic action of amphetamines, fenfluramine, phenmetrazine and diethylpropion in rats.
Topics: Amphetamine; Animals; Appetite Depressants; Body Weight; Diethylpropion; Drinking; Drug Tolerance; E | 1976 |
Effects of selective forebrain depletions of norepinephrine and serotonin on the activity and food intake effects of amphetamine and fenfluramine.
Topics: Amphetamines; Animals; Body Weight; Brain; Brain Stem; Dopamine; Feeding Behavior; Fenfluramine; Hyp | 1976 |
[Treatment of obesity with fenfluramine].
Topics: Adult; Aged; Blood Pressure; Body Weight; Depression; Drug Evaluation; Female; Fenfluramine; Humans; | 1975 |
Drug-induced alterations in hepatic fatty acid desaturase activity.
Topics: Animals; Appetite; Body Weight; Drinking; Fatty Acid Desaturases; Fatty Acids, Nonesterified; Fenflu | 1975 |
The effect of fenfluramine on disposition and rate of antipyrine elimination.
Topics: Adolescent; Adult; Animals; Antipyrine; Body Height; Body Weight; Female; Fenfluramine; Half-Life; H | 1975 |
A year's experience in a clinic for obese diabetics.
Topics: Adult; Aged; Body Weight; Coronary Disease; Diabetes Complications; Diabetes Mellitus; Diet, Reducin | 1975 |
A study of the energy and biochemical status of obese and non-obese students treated with 780SE.
Topics: Body Weight; Eating; Energy Metabolism; Fenfluramine; Humans; Lipids; Obesity | 1975 |
A six month study of a carbohydrate restricted diet in the management of maturity-onset diabetes and an evaluation of fenfluramine in patients unresponsive to this diet.
Topics: Adult; Aged; Body Weight; Diabetes Mellitus; Dietary Carbohydrates; Evaluation Studies as Topic; Fem | 1975 |
Assessment of new formulation of fenfluramine in the management of the obese, diabetic African.
Topics: Adult; Africa, Southern; Blood Pressure; Body Weight; Delayed-Action Preparations; Diabetes Mellitus | 1975 |
Comparisons between the behavioural and anorexic effects of 780SE and other phenylethylamines in the rat.
Topics: Amphetamines; Animals; Appetite; Behavior, Animal; Body Weight; Diethylpropion; Fenfluramine; Norfen | 1975 |
Fenfluramine and 780SE in experimental alcoholism in rats.
Topics: Alcohol Drinking; Alcohol Oxidoreductases; Animals; Body Weight; Fenfluramine; Liver; Male; Porphobi | 1975 |
DNA synthesis in adipose tissue.
Topics: Adipose Tissue; Animals; Body Weight; DNA; Female; Fenfluramine; Humans; Male; Rats | 1975 |
Pharmacological effects of 780SE (992) on hyperlipidaemic and obese rats.
Topics: Animals; Body Weight; Diabetes Mellitus, Experimental; Fatty Acids, Nonesterified; Female; Fenfluram | 1975 |
Effects of drug experience on drug induced conditioned taste aversions: studies with amphetamine and fenfluramine.
Topics: Animals; Avoidance Learning; Body Weight; Choice Behavior; Conditioning, Psychological; Dextroamphet | 1975 |
D-fenfluramine effects on hypothalamic monoamine activities and their hormonal correlates.
Topics: Animals; Body Weight; Dopamine; Fenfluramine; Hormones; Hypothalamus; Male; Norepinephrine; Rats; Ra | 1992 |
Administration of dexfenfluramine in pregnant rats: effect on brain serotonin parameters in offspring.
Topics: Animals; Animals, Newborn; Birth Weight; Body Weight; Brain Chemistry; Female; Fenfluramine; Pregnan | 1992 |
Disparate effects of fenfluramine on thermogenesis in brown adipose tissue in the rat.
Topics: Adipose Tissue, Brown; Anesthesia; Animals; Body Temperature Regulation; Body Weight; Fenfluramine; | 1992 |
Effect of chronic administration of dexfenfluramine on blood pressure in salt-sensitive rats.
Topics: Animals; Blood Pressure; Body Weight; Dose-Response Relationship, Drug; Drug Administration Schedule | 1992 |
Effects of chronically administered fluoxetine and fenfluramine on food intake, body weight and the behavioural satiety sequence.
Topics: Animals; Behavior, Animal; Body Weight; Feeding Behavior; Fenfluramine; Fluoxetine; Grooming; Male; | 1992 |
Sustained decreases in weight and serum insulin, glucose, triacylglycerol and cholesterol in JCR:LA-corpulent rats treated with D-fenfluramine.
Topics: Adipose Tissue; Aging; Animals; Blood Glucose; Body Weight; Cholesterol; Corticosterone; Eating; Fat | 1992 |
Role for brain corticotropin-releasing factor in the weight-reducing effects of chronic fenfluramine treatment in rats.
Topics: Adrenocorticotropic Hormone; Animals; Body Weight; Brain; Corticosterone; Corticotropin-Releasing Ho | 1991 |
Comparison of the effects of repeated oral versus subcutaneous fenfluramine administration on rat brain monoamine neurons: pharmacokinetic and dose-response data.
Topics: Administration, Oral; Animals; Biogenic Monoamines; Body Weight; Brain Chemistry; Chromatography, Hi | 1991 |
Decreased serum lipids, serum insulin and triacylglycerol synthesis in adipose tissue of JCR:LA-corpulent rats treated with benfluorex.
Topics: Adipose Tissue; Animals; Body Weight; Feeding Behavior; Female; Fenfluramine; Glucose; Hormones; Hyp | 1991 |
Effects of repeated administration of serotonergic agonists on diet selection and body weight in rats.
Topics: Animals; Body Weight; Diet; Drug Administration Schedule; Fenfluramine; Fluoxetine; Indoles; Male; R | 1991 |
Differences in the effects of acute and chronic administration of dexfenfluramine on cortisol and prolactin secretion.
Topics: Adrenocorticotropic Hormone; Adult; Animals; Body Weight; Corticosterone; Corticotropin-Releasing Ho | 1990 |
Dexfenfluramine: action with estradiol on food intake and body weight in ovariectomized rats.
Topics: Adipose Tissue; Animals; Blood Glucose; Body Weight; Drug Synergism; Eating; Estradiol; Female; Fenf | 1990 |
Long-term actions of d-fenfluramine in two rat models of obesity. II. Responses to stress.
Topics: Animals; Body Weight; Brain Chemistry; Cold Temperature; Corticosterone; Female; Fenfluramine; Obesi | 1990 |
Effects of repeated fenfluramine administration on indices of monoamine function in rat brain: pharmacokinetic, dose response, regional specificity and time course data.
Topics: Animals; Body Weight; Brain; Catecholamines; Dose-Response Relationship, Drug; Fenfluramine; Male; N | 1990 |
Effect of dexfenfluramine on gastric emptying of a mixed solid-liquid meal in obese subjects.
Topics: Adolescent; Adult; Body Weight; Female; Fenfluramine; Food; Gastric Emptying; Humans; Male; Middle A | 1990 |
Biochemical and functional effects of fenfluramine in maturing mice.
Topics: Age Factors; Animals; Body Temperature; Body Weight; Brain; Fenfluramine; Hydroxyindoleacetic Acid; | 1986 |
Effects of fenfluramine on food intake, body weight, gastric emptying and brain monoamines in Syrian hamsters.
Topics: Animals; Biogenic Amines; Body Weight; Brain Chemistry; Cricetinae; Dopamine; Dose-Response Relation | 1986 |
Effect of continuous infusions of dexfenfluramine on food intake, body weight and brain amines in rats.
Topics: Amines; Animals; Body Weight; Brain; Delayed-Action Preparations; Dopamine; Eating; Female; Fenflura | 1986 |
Reduction of normal food intake in rats and dogs and inhibition of experimentally induced hyperphagia in rats by CM 57373 and fenfluramine.
Topics: Animals; Appetite Depressants; Body Weight; Diet; Dogs; Eating; Feeding and Eating Disorders; Female | 1988 |
Decreased incorporation of glucose into lipids and increased lactate production by adipose tissue after long-term treatment of rats with D-fenfluramine.
Topics: Adipose Tissue; Animals; Body Weight; Carbon Dioxide; Dose-Response Relationship, Drug; Fatty Acids; | 1989 |
Effects of anorectic drugs on the topography of feeding behavior in baboons.
Topics: Animals; Appetite Depressants; Body Weight; Dose-Response Relationship, Drug; Feeding Behavior; Fenf | 1989 |
Lack of self-administration of different fenfluramine isomers in rats.
Topics: Animals; Arousal; Body Weight; Dextroamphetamine; Dose-Response Relationship, Drug; Fenfluramine; Hu | 1989 |
Interaction of adrenalectomy and fenfluramine treatment on body weight, food intake and brown adipose tissue.
Topics: Adipose Tissue, Brown; Adrenalectomy; Animals; Body Weight; Cholesterol; Corticosterone; Dose-Respon | 1989 |
Temporal changes in prolactin and corticosterone response during chronic treatment with d-fenfluramine.
Topics: Animals; Body Weight; Corticosterone; Drug Tolerance; Eating; Fenfluramine; Male; Prolactin; Rats; R | 1989 |
Effects of dexfenfluramine on the feeding behavior of rats foraging in the cold for palatable bait.
Topics: Animals; Body Weight; Cold Temperature; Conflict, Psychological; Dose-Response Relationship, Drug; F | 1989 |
Neurotransmitter control of carbohydrate consumption.
Topics: Amino Acids; Body Weight; Brain; Dietary Carbohydrates; Dietary Proteins; Eating; Energy Intake; Fen | 1985 |
Fawn hooded rats are subsensitive to the food intake suppressant effects of 5-HT agonists.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Body Weight; Eating; Fenfluramine; Male; Naphthalen | 1988 |
Effect of fenfluramine on sympathetic firing rate.
Topics: Animals; Blood Glucose; Body Weight; Energy Intake; Female; Fenfluramine; Insulin; Neural Conduction | 1988 |
Permanent administration of d-fenfluramine in rats: paradoxical effects.
Topics: Animals; Body Weight; Eating; Fenfluramine; Food Deprivation; Insulin; Male; Rats; Rats, Inbred Stra | 1988 |
Fenfluramine-induced suppression of food intake and locomotor activity is differentially altered by the selective type A monoamine oxidase inhibitor clorgyline.
Topics: Animals; Body Weight; Clorgyline; Drug Interactions; Eating; Fenfluramine; Male; Motor Activity; Pro | 1988 |
Brain and nutrition. Dexfenfluramine weight control and regulation of eating patterns. Satellite symposium to the Collegium Internationale Neuro-Psychopharmacologicum, 15th C.I.N.P. congress. Puerto Rico, U.S.A., December 14-17, 1987. Proceedings.
Topics: Animals; Appetite; Body Weight; Fenfluramine; Humans; Obesity | 1988 |
Enhancement of the thermic effect of food by d-fenfluramine.
Topics: Animals; Body Temperature Regulation; Body Weight; Eating; Energy Metabolism; Female; Fenfluramine; | 1988 |
Dexfenfluramine and body weight regulation: experimental study with hoarding behavior.
Topics: Animals; Behavior, Animal; Body Weight; Eating; Fenfluramine; Rats; Receptors, Serotonin | 1988 |
Do serotoninergic drugs decrease energy intake by reducing fat or carbohydrate intake? Effect of d-fenfluramine with supplemented weight-increasing diets.
Topics: Animals; Body Weight; Diet; Dietary Carbohydrates; Dietary Fats; Drinking Behavior; Energy Intake; F | 1988 |
Effects of chronic administration of benfluorex to rats on the metabolism of corticosterone, glucose, triacylglycerols, glycerol and fatty acid.
Topics: Animals; Appetite Depressants; Blood Glucose; Body Weight; Corticosterone; Eating; Fatty Acids; Fenf | 1988 |
Involvement of endogenous opioid peptides in fenfluramine anorexia.
Topics: Animals; Anorexia; Body Weight; Duodenum; Endorphins; Feeding and Eating Disorders; Feeding Behavior | 1986 |
Action of fenfluramine, phenylpropanolamine, phentermine and diethylpropion on acoustic startle in rats.
Topics: Acoustic Stimulation; Animals; Appetite Depressants; Body Weight; Diethylpropion; Drug Tolerance; Fe | 1987 |
Dextrofenfluramine increases energy cost of muscular effort.
Topics: Animals; Body Weight; Carbohydrate Metabolism; Dietary Fats; Dietary Proteins; Eating; Energy Metabo | 1986 |
Effect of dexfenfluramine on body weight set-point: study in the rat with hoarding behaviour.
Topics: Animals; Appetite Depressants; Body Weight; Energy Metabolism; Feeding Behavior; Fenfluramine; Homeo | 1986 |
Metabolic mechanism of the anorectic and leptogenic effects of the serotonin agonist fenfluramine.
Topics: Animals; Appetite Depressants; Body Weight; Eating; Energy Metabolism; Feeding Behavior; Fenfluramin | 1986 |
Anorectics and the set point theory for regulation of body weight.
Topics: Animals; Body Weight; Drug Administration Schedule; Feeding Behavior; Fenfluramine; Male; Rats; Rats | 1986 |
Lateral hypothalamic lesions and fenfluramine increase thermogenesis in brown adipose tissue.
Topics: Adipose Tissue, Brown; Animals; Body Weight; Female; Fenfluramine; Guanine Nucleotides; Guanosine Di | 1986 |
Dietary self-selection and intake of protein and energy is altered by the form of the diets.
Topics: Animals; Body Weight; Dietary Proteins; Energy Intake; Fenfluramine; Food Preferences; Male; Rats | 1986 |
Body weight set point theory.
Topics: Amphetamines; Animals; Appetite; Body Weight; Energy Intake; Feeding Behavior; Fenfluramine; Homeost | 1985 |
Possible relationships between changes in body weight set-point and stress metabolism after treating rats chronically with D-fenfluramine. Effects of feeding rats acutely with fructose on the metabolism of corticosterone, glucose, fatty acids, glycerol an
Topics: Adipose Tissue; Animals; Blood Glucose; Body Weight; Corticosterone; Diet; Dietary Carbohydrates; Di | 1985 |
The effect of previous d-amphetamine treatment on the disposition and lethality of fenfluramine in the rat.
Topics: Amphetamine; Animals; Body Weight; Drug Interactions; Fenfluramine; Half-Life; Injections, Intraperi | 1985 |
Long-term treatment with fenfluramine in obese subjects.
Topics: Adipose Tissue; Adolescent; Adult; Body Weight; Diet, Reducing; Female; Fenfluramine; Glucose Tolera | 1985 |
Effect of fenfluramine on GDP-binding to brown adipose tissue mitochondria.
Topics: Adipose Tissue, Brown; Animals; Body Weight; Dose-Response Relationship, Drug; Eating; Female; Fenfl | 1985 |
Effects of initial body weight on anorexia and tolerance to fenfluramine in rats.
Topics: Animals; Appetite Depressants; Body Weight; Drug Tolerance; Female; Fenfluramine; Rats; Rats, Inbred | 1985 |
Action of fenfluramine.
Topics: Anorexia Nervosa; Body Weight; Fenfluramine; Humans; Male; Obesity | 1973 |
Fenfluramine: amphetamine congener that fails to maintain drug-taking behavior in the rhesus monkey.
Topics: Animals; Behavior, Animal; Body Weight; Cocaine; Conditioning, Operant; Dose-Response Relationship, | 1974 |
Chronic fenfluramine administration: some cerebral effects.
Topics: Adult; Appetite Depressants; Body Weight; Brain; Bruxism; Drug Tolerance; Electroencephalography; Fe | 1971 |
Central action of anorexic agents: effects of amphetamine and fenfluramine in rats with lateral hypothalamic lesions.
Topics: Amphetamine; Analysis of Variance; Animals; Appetite Depressants; Body Weight; Feeding Behavior; Fen | 1974 |
Pharmacology of a halogenated aralkylamine with anorectic properties.
Topics: Animals; Appetite Depressants; Autonomic Nervous System; Blood Pressure; Body Temperature; Body Weig | 1972 |
[Treatment of the risk factor overweight].
Topics: Age Factors; Body Weight; Female; Fenfluramine; Humans; Male; Middle Aged; Obesity | 1973 |
Dissociation of the anorexic effects of fenfluramine and amphetamine following intrahypothalamic injection.
Topics: Amphetamine; Animals; Appetite Depressants; Body Weight; Feeding Behavior; Fenfluramine; Hypothalamu | 1973 |
Fenfluramine and triglyceride synthesis by microsomes of the intestinal mucosa in the rat.
Topics: Acyltransferases; Animals; Body Weight; Dietary Fats; Female; Fenfluramine; Intestinal Absorption; I | 1973 |
[Insulin secretion and hydrocarbon tolerance in essential obesity in women (influence of fenfluramine, phenformin and D-amphetamine)].
Topics: Administration, Oral; Blood Glucose; Body Weight; Dextroamphetamine; Evaluation Studies as Topic; Fe | 1973 |
Ascorbic acid and cholesterol mobilization by fenfluramine.
Topics: Animals; Ascorbic Acid; Body Weight; Cholesterol; Diet; Female; Fenfluramine; Guinea Pigs; Lipid Mob | 1973 |
Suppression of the drug-induced morphine withdrawal syndrome by cyproheptadine.
Topics: Animals; Body Weight; Cyproheptadine; Drug Tolerance; Fenfluramine; Humans; Hypothalamus; Levallorph | 1973 |
The effects of chronic fenfluramine administration on behaviour and body weight.
Topics: Amphetamine; Animals; Behavior, Animal; Body Weight; Drug Tolerance; Fenfluramine; Grooming; Humans; | 1973 |
[Influence of fenfluramine on the weekly curve of weight loss during obesity].
Topics: Adolescent; Adult; Body Weight; Diet, Reducing; Drug Evaluation; Female; Fenfluramine; Humans; Middl | 1974 |
Chronic anorexic and behavioural effects of the fenfluramine metabolite, norfenfluramine: an evaluation of its role in the actions of fenfluramine.
Topics: Animals; Appetite; Appetite Depressants; Behavior, Animal; Body Weight; Drug Tolerance; Fenfluramine | 1974 |
[Comparative action of fenfluramine and amphetamine in rats with hypothalamic obesity].
Topics: Amphetamine; Animal Nutritional Physiological Phenomena; Animals; Appetite Depressants; Body Weight; | 1969 |
Effect of fenfluramine on the electrical activity of the hypothalamic feeding centers.
Topics: Animals; Appetite; Appetite Depressants; Blood Glucose; Body Weight; Brain Mapping; Consummatory Beh | 1971 |
Experimental evaluation of anorexigenic agents in man: a pilot study.
Topics: Adult; Appetite; Appetite Depressants; Body Weight; Diethylpropion; Fenfluramine; Humans; Male; Phen | 1972 |
Effects of the fenfluramine derivative 'S992' on body-weight and blood lipids in man.
Topics: Adult; Appetite Depressants; Blood Glucose; Body Weight; Cholesterol; Fatty Acids, Nonesterified; Fe | 1971 |
Drugs of dependence though not of abuse: fenfluramine and imipramine.
Topics: Adult; Appetite Depressants; Body Weight; Depression; Dreams; Female; Fenfluramine; Fluorine; Humans | 1971 |
Effect of fenfluramine on appetite and lipid metabolism of the young ruminant.
Topics: Age Factors; Animals; Appetite; Appetite Depressants; Blood Glucose; Body Weight; Cattle; Cholestero | 1970 |
The inhibitory effect of fenfluramine on pancreatic lipase activity.
Topics: Analysis of Variance; Appetite Depressants; Body Weight; Chemical Phenomena; Chemistry; Dialysis; Fa | 1971 |
Anorexigenic effects of fenfluramine hydrochloride in rats, guinea pigs, and dogs.
Topics: Animals; Appetite; Appetite Depressants; Appetite Regulation; Behavior, Animal; Body Weight; Dextroa | 1969 |