fenfluramine has been researched along with Bipolar Disorder in 23 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Bipolar Disorder: A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Prolactin (PRL) and cortisol responses to oral administration of d-1 fenfluramine hydrochloride (60 mg) and placebo were examined in patients with endogenous major depressive disorder on three separate occasions: prior to treatment with clomipramine (CMI), after 4 weeks of CMI administration (175-250) mg/day), and 3 weeks after addition of lithium (Li) carbonate (serum level 0." | 5.07 | Effect of clomipramine and lithium on fenfluramine-induced hormone release in major depression. ( Gropp, C; Lerer, B; Newman, M; Shapira, B; Yagmur, MJ, 1992) |
| " The apparently complex influence of weight loss on prolactin response to serotonergic challenge remains to be clarified as well as the role played by the bioavailability of the challenge drug and its metabolite." | 2.67 | Hormone responses to fenfluramine and placebo challenge in endogenous depression. ( Cooper, TB; Gillon, D; Kindler, S; Lerer, B; Lichtenberg, P; Newman, ME; Shapira, B, 1992) |
| "Fenfluramine 40-120 mg/day was then added to the ongoing desipramine in a placebo substitution design." | 2.67 | Fenfluramine augmentation in tricyclic-refractory depression. ( Charney, DS; Delgado, PL; Heninger, GR; Price, LH, 1990) |
| "d-Fenfluramine (30 mg p." | 1.29 | d-fenfluramine-induced prolactin responses in mania: evidence for serotonergic subsensitivity. ( Dinan, TG; O'Keane, V; Thakore, JH, 1996) |
| " During the last decade, animal data have provided considerable evidence that chronic administration of lithium within a "therapeutic range" induces 5-HT agonistic effects in the brain." | 1.27 | Lithium long-term treatment--does it act via serotonin? ( Müller-Oerlinghausen, B, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (30.43) | 18.7374 |
| 1990's | 12 (52.17) | 18.2507 |
| 2000's | 3 (13.04) | 29.6817 |
| 2010's | 1 (4.35) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sublette, ME | 1 |
| Milak, MS | 1 |
| Galfalvy, HC | 1 |
| Oquendo, MA | 2 |
| Malone, KM | 3 |
| Mann, JJ | 3 |
| Kegeles, LS | 1 |
| Slifstein, M | 1 |
| Ellis, SP | 1 |
| Xanthopoulos, E | 1 |
| Keilp, JG | 1 |
| Campbell, C | 1 |
| Oquendo, M | 1 |
| Van Heertum, RL | 1 |
| Sher, L | 1 |
| Li, S | 1 |
| Ellis, S | 1 |
| Brodsky, BS | 1 |
| Cooper, TB | 2 |
| Silverstone, T | 2 |
| Mühlbauer, HD | 2 |
| Yatham, LN | 1 |
| Thakore, JH | 1 |
| O'Keane, V | 1 |
| Dinan, TG | 1 |
| Raison, CL | 1 |
| Klein, HM | 1 |
| Bowden, CL | 1 |
| Dickson, J | 1 |
| Bagri, S | 1 |
| Reddy, G | 1 |
| Zimmer, JE | 1 |
| Gregory, RJ | 1 |
| Knott, VJ | 1 |
| Howson, AL | 1 |
| Perugini, M | 1 |
| Ravindran, AV | 1 |
| Young, SN | 1 |
| Sarchiapone, M | 1 |
| Camardese, G | 1 |
| Roy, A | 1 |
| Della Casa, S | 1 |
| Satta, MA | 1 |
| Gonzalez, B | 1 |
| Berman, J | 1 |
| De Risio, S | 1 |
| Cookson, J | 1 |
| Lichtenberg, P | 2 |
| Shapira, B | 3 |
| Gillon, D | 1 |
| Kindler, S | 1 |
| Newman, ME | 1 |
| Lerer, B | 4 |
| Yagmur, MJ | 1 |
| Gropp, C | 2 |
| Newman, M | 1 |
| Blacker, M | 1 |
| Calev, A | 1 |
| Mitchell, P | 1 |
| Smythe, G | 1 |
| Price, LH | 1 |
| Charney, DS | 1 |
| Delgado, PL | 1 |
| Heninger, GR | 1 |
| Müller-Oerlinghausen, B | 2 |
| Pearce, JB | 1 |
2 reviews available for fenfluramine and Bipolar Disorder
| Article | Year |
|---|---|
The clinical pharmacology of appetite--its relevance to psychiatry.
Topics: Amphetamine; Anorexia; Appetite; Bipolar Disorder; Brain Chemistry; Depressive Disorder; Dopamine; F | 1983 |
Alternative therapies for bipolar disorder.
Topics: Ascorbic Acid; Bipolar Disorder; Bupropion; Carbamazepine; Choline; Clonazepam; Clonidine; Clorgylin | 1985 |
9 trials available for fenfluramine and Bipolar Disorder
| Article | Year |
|---|---|
Regional brain glucose uptake distinguishes suicide attempters from non-attempters in major depression.
Topics: Adult; Bipolar Disorder; Brain; Case-Control Studies; Caudate Nucleus; Depressive Disorder, Major; F | 2013 |
Response of cortical metabolic deficits to serotonergic challenge in familial mood disorders.
Topics: Adult; Affect; Bipolar Disorder; Blood Glucose; Brain Mapping; Depressive Disorder, Major; Energy Me | 2003 |
Prolactin response to fenfluramine administration in patients with unipolar and bipolar depression and healthy controls.
Topics: Adult; Age Distribution; Bipolar Disorder; Depressive Disorder, Major; Disease Susceptibility; Femal | 2003 |
The effect of acute tryptophan depletion and fenfluramine on quantitative EEG and mood in healthy male subjects.
Topics: Adolescent; Adult; Affect; Amino Acids; Bipolar Disorder; Double-Blind Method; Electroencephalograph | 1999 |
Hormone responses to fenfluramine and placebo challenge in endogenous depression.
Topics: Adult; Affective Disorders, Psychotic; Aged; Bipolar Disorder; Depressive Disorder; Double-Blind Met | 1992 |
Effect of clomipramine and lithium on fenfluramine-induced hormone release in major depression.
Topics: Adult; Bipolar Disorder; Clomipramine; Depressive Disorder; Double-Blind Method; Drug Therapy, Combi | 1992 |
Effect of fenfluramine on mood: a double-blind placebo-controlled trial.
Topics: Adult; Affect; Arousal; Bipolar Disorder; Depressive Disorder; Double-Blind Method; Female; Fenflura | 1992 |
Fenfluramine augmentation in tricyclic-refractory depression.
Topics: Adult; Aged; Bipolar Disorder; Depressive Disorder; Desipramine; Drug Therapy, Combination; Female; | 1990 |
Fenfluramine in mania.
Topics: Bipolar Disorder; Clinical Trials as Topic; Fenfluramine; Humans; Placebos | 1973 |
12 other studies available for fenfluramine and Bipolar Disorder
| Article | Year |
|---|---|
The influence of fenfluramine stimulation on prolactin plasma levels in lithium long-term-treated manic-depressive patients and healthy subjects.
Topics: Adult; Bipolar Disorder; Female; Fenfluramine; Humans; Lithium; Male; Prolactin; Sex Factors | 1984 |
Prolactin and cortisol responses to fenfluramine challenge in mania.
Topics: Adult; Arousal; Bipolar Disorder; Brain; Female; Fenfluramine; Humans; Hydrocortisone; Male; Middle | 1996 |
d-fenfluramine-induced prolactin responses in mania: evidence for serotonergic subsensitivity.
Topics: Adult; Bipolar Disorder; Female; Fenfluramine; Hospitalization; Humans; Hydrocortisone; Male; Middle | 1996 |
Psychotic mania associated with fenfluramine and phentermine use.
Topics: 1-Naphthylamine; Bipolar Disorder; Depressive Disorder; Female; Fenfluramine; Humans; Middle Aged; O | 1997 |
Mania from dexfenfluramine.
Topics: Anti-Obesity Agents; Bipolar Disorder; Female; Fenfluramine; Humans; Middle Aged; Weight Gain | 1997 |
Delirium with manic symptoms induced by diet pills.
Topics: Adolescent; Bipolar Disorder; Delirium; Drug Therapy, Combination; Female; Fenfluramine; Humans; Mid | 1998 |
Bipolar depression associated with fenfluramine and phentermine.
Topics: Adult; Appetite Depressants; Bipolar Disorder; Drug Therapy, Combination; Female; Fenfluramine; Huma | 1998 |
Cholesterol and serotonin indices in depressed and suicidal patients.
Topics: Adult; Analysis of Variance; Bipolar Disorder; Case-Control Studies; Cholesterol; Depressive Disorde | 2001 |
5-Hydroxytryptamine and dopamine pathways in mania: a pilot study of fenfluramine and pimozide.
Topics: Adult; Aged; Bipolar Disorder; Dopamine; Fenfluramine; Humans; Middle Aged; Pilot Projects; Pimozide | 1976 |
Hormonal responses to fenfluramine in depressed and control subjects.
Topics: Adult; Bipolar Disorder; Depressive Disorder; Diazepam; Female; Fenfluramine; Humans; Hydrocortisone | 1990 |
Fenfluramine stimulation of serum cortisol in patients with major affective disorders and healthy controls: further evidence for a central serotonergic action of lithium in man.
Topics: Adult; Bipolar Disorder; Blood Glucose; Depressive Disorder; Female; Fenfluramine; Humans; Hydrocort | 1985 |
Lithium long-term treatment--does it act via serotonin?
Topics: Animals; Bipolar Disorder; Brain; Fenfluramine; Humans; Hydrocortisone; Lithium; Long-Term Care; Pro | 1985 |