fenfluramine has been researched along with Bilateral Headache in 9 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In idiopathic headache (IH) sufferers, phenylephrine and fenfluramine induce a pupillary dilatation respectively greater and lesser than in controls." | 3.65 | Adrenergic supersensitivity of the pupil in idiopathic headache. ( Fanciullacci, M; Galli, P; Pietrini, U; Sicuteri, F, 1977) |
| "Sixteen children with benign paroxysmal vertigo (BPV) are presented." | 1.27 | Benign paroxysmal vertigo in childhood. Diagnostic significance of vestibular examination and headache provocation tests. ( Balottin, U; Lanzi, G; Mira, E; Piacentino, G, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (88.89) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fanciullacci, M | 3 |
| Pietrini, U | 3 |
| Boccuni, M | 1 |
| Mira, E | 1 |
| Piacentino, G | 1 |
| Lanzi, G | 1 |
| Balottin, U | 1 |
| Panconesi, A | 1 |
| Sicuteri, R | 1 |
| Galli, P | 2 |
| Sicuteri, F | 2 |
| Sircuteri, F | 1 |
| Del Bene, E | 1 |
| Anselmi, B | 2 |
| Monetti, MG | 1 |
| Bene, E | 1 |
| Sicusteri, F | 1 |
| Del Bianco, PL | 1 |
| Stunkard, A | 1 |
| Rickels, K | 1 |
| Hesbacher, P | 1 |
| Dykes, MH | 1 |
1 review available for fenfluramine and Bilateral Headache
| Article | Year |
|---|---|
Headache induced by serotonergic agonists--a key to the interpretation of migraine pathogenesis?
Topics: Animals; Fenfluramine; Headache; Humans; Hypersensitivity; Piperazines; Receptors, Serotonin; Seroto | 1997 |
3 trials available for fenfluramine and Bilateral Headache
| Article | Year |
|---|---|
Fenfluramine headache.
Topics: Adult; Brain; Clinical Trials as Topic; Dose-Response Relationship, Drug; Female; Fenfluramine; Head | 1976 |
Fenfluramine in the treatment of obesity.
Topics: Adult; Appetite Depressants; Body Weight; Clinical Trials as Topic; Constipation; Dextroamphetamine; | 1973 |
Evaluation of three anorexiants. Clortermine hydrochloride (voranil), fenfluramine hydrochloride (pondimin), and mazindol (sanorex).
Topics: Adolescent; Adult; Age Factors; Appetite Depressants; Clinical Trials as Topic; Depression; Diet, Re | 1974 |
5 other studies available for fenfluramine and Bilateral Headache
| Article | Year |
|---|---|
Disruption of iris adrenergic transmission as an index of poor endorphin modulation in headache.
Topics: Endorphins; Fenfluramine; Guanethidine; Headache; Humans; Iris; Neuroeffector Junction; Phenylephrin | 1982 |
Benign paroxysmal vertigo in childhood. Diagnostic significance of vestibular examination and headache provocation tests.
Topics: Child; Child, Preschool; Female; Fenfluramine; Headache; Histamine; Humans; Male; Nitroglycerin; Ver | 1984 |
Adrenergic supersensitivity of the pupil in idiopathic headache.
Topics: Adult; Female; Fenfluramine; Headache; Humans; Hypersensitivity; Iris; Male; Middle Aged; Phenylephr | 1977 |
[Pupillary pharmacology in idiopathic headache].
Topics: Fenfluramine; Headache; Humans; Phenylephrine; Pupil; Sympathetic Nervous System | 1976 |
[Fenfluramine and headche: pharmaco-clinical implications].
Topics: Drug Evaluation; Fenfluramine; Headache; Humans; Lipid Mobilization; Vasoconstrictor Agents | 1975 |