fenfluramine has been researched along with Behavior Disorders in 13 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fenfluramine has been used for a number of years as a short-term adjunct to diet in the management of obesity." | 8.75 | Fenfluramine: a review of its pharmacological properties and therapeutic efficacy in obesity. ( Avery, GS; Brogden, RN; Pinder, RM; Sawyer, PR; Speight, TM, 1975) |
| "Fenfluramine has been used for a number of years as a short-term adjunct to diet in the management of obesity." | 4.75 | Fenfluramine: a review of its pharmacological properties and therapeutic efficacy in obesity. ( Avery, GS; Brogden, RN; Pinder, RM; Sawyer, PR; Speight, TM, 1975) |
| "The CSF AVP level was correlated directly with life history of general aggression and aggression against persons and inversely with PRL[d-FEN] responses (but not with CSF 5-hydroxyindoleacetic acid), which in turn was correlated inversely with these 2 measures of life history of aggression." | 3.70 | Cerebrospinal fluid vasopressin levels: correlates with aggression and serotonin function in personality-disordered subjects. ( Coccaro, EF; Cooper, TB; Ferris, CF; Hauger, RL; Kavoussi, RJ, 1998) |
| "Parents of children with mental retardation or borderline IQ who took part in two drug studies were surveyed by mail 4 weeks after their involvement." | 2.68 | Consumer satisfaction with involvement in drug research: a social validity study. ( Aman, MG; Wolford, PL, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (23.08) | 18.7374 |
| 1990's | 7 (53.85) | 18.2507 |
| 2000's | 3 (23.08) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Malone, KM | 1 |
| Waternaux, C | 1 |
| Haas, GL | 1 |
| Cooper, TB | 2 |
| Li, S | 1 |
| Mann, JJ | 3 |
| Manuck, SB | 1 |
| Bleil, ME | 1 |
| Petersen, KL | 1 |
| Flory, JD | 1 |
| Ferrell, RE | 1 |
| Muldoon, MF | 1 |
| Aman, MG | 1 |
| Wolford, PL | 1 |
| Smith, GS | 1 |
| Dewey, SL | 1 |
| Brodie, JD | 1 |
| Logan, J | 1 |
| Vitkun, SA | 1 |
| Simkowitz, P | 1 |
| Schloesser, R | 1 |
| Alexoff, DA | 1 |
| Hurley, A | 1 |
| Cooper, T | 1 |
| Volkow, ND | 1 |
| Coccaro, EF | 2 |
| Kavoussi, RJ | 1 |
| Hauger, RL | 1 |
| Ferris, CF | 1 |
| McCann, UD | 1 |
| Eligulashvili, V | 1 |
| Ricaurte, GA | 1 |
| Hilts, PJ | 1 |
| Mulder, RT | 1 |
| Joyce, PR | 1 |
| Pinder, RM | 1 |
| Brogden, RN | 1 |
| Sawyer, PR | 1 |
| Speight, TM | 1 |
| Avery, GS | 1 |
| McBride, PA | 1 |
| Brown, RP | 1 |
| Linnoila, M | 1 |
| Leon, AC | 1 |
| DeMeo, M | 1 |
| Mieczkowski, T | 1 |
| Myers, JE | 1 |
| Stanley, M | 1 |
| Siever, LJ | 1 |
| Trestman, RL | 1 |
| Gabriel, S | 1 |
| Murphy, DL | 1 |
| Mueller, EA | 1 |
| Garrick, NA | 1 |
| Aulakh, CS | 1 |
| Gaind, R | 1 |
2 reviews available for fenfluramine and Behavior Disorders
| Article | Year |
|---|---|
Fenfluramine: a review of its pharmacological properties and therapeutic efficacy in obesity.
Topics: Adult; Age Factors; Analgesics; Anticonvulsants; Appetite Depressants; Body Temperature; Central Ner | 1975 |
Use of serotonergic agents in the clinical assessment of central serotonin function.
Topics: 5-Hydroxytryptophan; Animals; Brain; Brain Chemistry; Fenfluramine; Humans; Mental Disorders; Mice; | 1986 |
2 trials available for fenfluramine and Behavior Disorders
| Article | Year |
|---|---|
Consumer satisfaction with involvement in drug research: a social validity study.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Child; Child, Preschool; Clinical Trials | 1995 |
Fenfluramine (Ponderax) in the treatment of obese psychiatric out-patients.
Topics: Anxiety Disorders; Appetite Depressants; Body Weight; Clinical Trials as Topic; Depression; Diarrhea | 1969 |
9 other studies available for fenfluramine and Behavior Disorders
| Article | Year |
|---|---|
Cigarette smoking, suicidal behavior, and serotonin function in major psychiatric disorders.
Topics: Adolescent; Adult; Aged; Comorbidity; Depressive Disorder; Female; Fenfluramine; Humans; Hydrocortis | 2003 |
The socio-economic status of communities predicts variation in brain serotonergic responsivity.
Topics: Adult; Alleles; Brain; Female; Fenfluramine; Genotype; Humans; Male; Membrane Glycoproteins; Membran | 2005 |
Serotonergic modulation of dopamine measured with [11C]raclopride and PET in normal human subjects.
Topics: Aged; Carbon Radioisotopes; Cerebellum; Corpus Striatum; Dopamine; Dopamine Antagonists; Fenfluramin | 1997 |
Cerebrospinal fluid vasopressin levels: correlates with aggression and serotonin function in personality-disordered subjects.
Topics: Adult; Aggression; Arginine Vasopressin; Female; Fenfluramine; Humans; Hydroxyindoleacetic Acid; Imp | 1998 |
Adverse neuropsychiatric events associated with dexfenfluramine and fenfluramine.
Topics: Adolescent; Adult; Affect; Aged; Anxiety; Appetite Depressants; Cognition Disorders; Dexfenfluramine | 1998 |
Experiments on children are reviewed: research involved now-banned drug.
Topics: Advisory Committees; Aggression; Behavioral Research; Black or African American; Child; Federal Gove | 1998 |
Relationship of temperament and behaviour measures to the prolactin response to fenfluramine in depressed men.
Topics: Adolescent; Adult; Depressive Disorder, Major; Fenfluramine; Humans; Male; Mental Disorders; Middle | 2002 |
Relationship between central and peripheral serotonin indexes in depressed and suicidal psychiatric inpatients.
Topics: Adult; Blood Platelets; Depressive Disorder; Female; Fenfluramine; Hospitalization; Humans; Hydroxyi | 1992 |
Use of serotonin-active agents in other psychiatric disorders.
Topics: Aggression; Fenfluramine; Humans; Impulsive Behavior; Male; Mental Disorders; Personality Disorders; | 1992 |