fenfluramine has been researched along with Back Ache in 1 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Patients with chronic low-back pain and depression were treated double blind with desipramine or doxepin." | 5.06 | Tricyclic antidepressants for chronic low-back pain. Mechanisms of action and predictors of response. ( Ward, NG, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ward, NG | 1 |
1 trial available for fenfluramine and Back Ache
| Article | Year |
|---|---|
Tricyclic antidepressants for chronic low-back pain. Mechanisms of action and predictors of response.
Topics: Adult; Back Pain; Chronic Disease; Clinical Trials as Topic; Depressive Disorder; Desipramine; Doubl | 1986 |