fenfluramine has been researched along with Autistic Disorder in 59 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Autistic Disorder: A disorder beginning in childhood. It is marked by the presence of markedly abnormal or impaired development in social interaction and communication and a markedly restricted repertoire of activity and interest. Manifestations of the disorder vary greatly depending on the developmental level and chronological age of the individual. (DSM-V)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fifteen children with autism were treated with 60 mg d,l-fenfluramine (FEN) or placebo in a double-blind A-B-A protocol followed immediately by double-blind placebo-controlled crossover administration of FEN (total duration 62 weeks)." | 9.07 | Clinical and neurochemical effects of fenfluramine in children with autism. ( Cook, EH; Freedman, DX; Heller, W; Leventhal, BL; Morford, M; Ravitz, AJ, 1993) |
| "We report a 12 month double-blind randomized crossover trial of fenfluramine in 20 children with the syndrome of autism." | 9.06 | A controlled crossover trial of fenfluramine in autism. ( Badcock, NR; Oades, RD; Sawyer, MG; Spence, JG; Stern, LM; Walker, MK, 1990) |
| "The effects of fenfluramine were examined on 20 children with autism over a 48-week period utilizing a double-blind placebo-controlled crossover design." | 9.06 | Fenfluramine treatment of twenty children with autism. ( Ekman, G; Garle, M; Gillberg, C; Miranda-Linné, F; Wetterberg, L, 1989) |
| "Nine children meeting DSM-III criteria for infantile autism were treated with fenfluramine hydrochloride or inactive placebo in a double-blind crossover trial that followed the protocol for the fenfluramine multicenter study." | 9.06 | Fenfluramine treatment of autism: relationship of treatment response to blood levels of fenfluramine and norfenfluramine. ( Beeghly, JH; Kuperman, S; Perry, PJ; Tsai, LY; Wright, GJ, 1987) |
| "Fenfluramine was administered to 14 outpatient children with the syndrome of autism to determine whether previously produced decreases in blood serotonin concentrations and clinical improvements could be reinstituted." | 9.05 | Study of fenfluramine in outpatients with the syndrome of autism. ( Freeman, BJ; Geller, E; Novak, P; Ritvo, ER; Schroth, P; Yokota, A; Yuwiler, A, 1984) |
| "A review of research studies published to date on the effects of fenfluramine on children with autism is presented." | 8.77 | Clinical effects of fenfluramine on children with autism: a review of the research. ( Banks, SR; du Verglas, G; Guyer, KE, 1988) |
| "Fenfluramine was administered to eight autistic outpatients in a double-blind study to determine its effects on symptomatic behavior, developmental scores, blood serotonin levels and platelet counts." | 6.66 | Effects of fenfluramine on eight outpatients with the syndrome of autism. ( Budden, SS; Jackson, RH; Ritvo, ER; Stubbs, EG; Terdal, LG, 1986) |
| " The mean daily dosage was 0." | 6.37 | [Evaluation of the treatment with fenfluramine of autism in children]. ( Ceillier-Hoppenot, B; Dalery, J; de Villard, R; Flachaire, E; Maillet, J; Mamelle, JC; Quincy, C; Rebaud, B; Revol, O, 1988) |
| "Fifteen children with autism were treated with 60 mg d,l-fenfluramine (FEN) or placebo in a double-blind A-B-A protocol followed immediately by double-blind placebo-controlled crossover administration of FEN (total duration 62 weeks)." | 5.07 | Clinical and neurochemical effects of fenfluramine in children with autism. ( Cook, EH; Freedman, DX; Heller, W; Leventhal, BL; Morford, M; Ravitz, AJ, 1993) |
| "We report a 12 month double-blind randomized crossover trial of fenfluramine in 20 children with the syndrome of autism." | 5.06 | A controlled crossover trial of fenfluramine in autism. ( Badcock, NR; Oades, RD; Sawyer, MG; Spence, JG; Stern, LM; Walker, MK, 1990) |
| "The effects of fenfluramine were examined on 20 children with autism over a 48-week period utilizing a double-blind placebo-controlled crossover design." | 5.06 | Fenfluramine treatment of twenty children with autism. ( Ekman, G; Garle, M; Gillberg, C; Miranda-Linné, F; Wetterberg, L, 1989) |
| " To pursue an antiserotonergic treatment rationale for autistic disorder, an open-blind 4-week trial comparing buspirone to fenfluramine or methylphenidate was conducted." | 5.06 | Clinical effect of buspirone in autistic children. ( August, GJ; Garfinkel, BD; Realmuto, GM, 1989) |
| "Nine children meeting DSM-III criteria for infantile autism were treated with fenfluramine hydrochloride or inactive placebo in a double-blind crossover trial that followed the protocol for the fenfluramine multicenter study." | 5.06 | Fenfluramine treatment of autism: relationship of treatment response to blood levels of fenfluramine and norfenfluramine. ( Beeghly, JH; Kuperman, S; Perry, PJ; Tsai, LY; Wright, GJ, 1987) |
| "Several recent studies have described the benefits of fenfluramine for the symptomatic treatment of infantile autism." | 5.06 | Untoward effects of fenfluramine in autistic children. ( Freeman, BJ; Geller, E; Jensen, J; Klykylo, W; Piggott, L; Realmuto, GM; Ritvo, E; Stubbs, G; Yuwiler, A, 1986) |
| "Fenfluramine was administered to 14 outpatient children with the syndrome of autism to determine whether previously produced decreases in blood serotonin concentrations and clinical improvements could be reinstituted." | 5.05 | Study of fenfluramine in outpatients with the syndrome of autism. ( Freeman, BJ; Geller, E; Novak, P; Ritvo, ER; Schroth, P; Yokota, A; Yuwiler, A, 1984) |
| "A review of research studies published to date on the effects of fenfluramine on children with autism is presented." | 4.77 | Clinical effects of fenfluramine on children with autism: a review of the research. ( Banks, SR; du Verglas, G; Guyer, KE, 1988) |
| "Six children with autism, who were treated with fenfluramine as part of a multi-center double-blind placebo-controlled crossover design study, were continued on an open trial of this medication." | 3.68 | A two-year follow-up of autistic children treated with fenfluramine. ( Holm, VA; Varley, CK, 1990) |
| " Polygraphic recording showed two types of syncope, one induced by prolonged apnea and the other by a prolonged Valsalva maneuver." | 3.67 | Compulsive respiratory stereotypies in children with autistic features: polygraphic recording and treatment with fenfluramine. ( Gastaut, H; Rufo, M; Zifkin, B, 1987) |
| "5 years old) with a compulsive eating disorder and gross obesity was treated with a combination of behavior therapy and fenfluramine (Ponderax)." | 3.67 | [Treatment of compulsive eating disorders in an autistic girl by combining behavior therapy and pharmacotherapy. Case report]. ( Hackler, J, 1986) |
| "Fenfluramine was administered to eight autistic outpatients in a double-blind study to determine its effects on symptomatic behavior, developmental scores, blood serotonin levels and platelet counts." | 2.66 | Effects of fenfluramine on eight outpatients with the syndrome of autism. ( Budden, SS; Jackson, RH; Ritvo, ER; Stubbs, EG; Terdal, LG, 1986) |
| "improves the core features of autism (social interaction, communication and behavioural problems);2." | 2.49 | Selective serotonin reuptake inhibitors (SSRIs) for autism spectrum disorders (ASD). ( Brignell, A; Hazell, P; Randall, M; Silove, N; Williams, K, 2013) |
| "improves the core features of autism (social interaction, communication and behavioural problems); 2." | 2.46 | Selective serotonin reuptake inhibitors (SSRIs) for autism spectrum disorders (ASD). ( Hazell, P; Silove, N; Wheeler, DM; Williams, K, 2010) |
| "Fenfluramine (n = 104) was third, with a ratio of 1." | 2.37 | Controversies in the treatment of autistic children: vitamin and drug therapy. ( Rimland, B, 1988) |
| " The mean daily dosage was 0." | 2.37 | [Evaluation of the treatment with fenfluramine of autism in children]. ( Ceillier-Hoppenot, B; Dalery, J; de Villard, R; Flachaire, E; Maillet, J; Mamelle, JC; Quincy, C; Rebaud, B; Revol, O, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 50 (84.75) | 18.7374 |
| 1990's | 7 (11.86) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (3.39) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Williams, K | 2 |
| Brignell, A | 1 |
| Randall, M | 1 |
| Silove, N | 2 |
| Hazell, P | 2 |
| Wheeler, DM | 1 |
| August, GJ | 7 |
| Raz, N | 5 |
| Papanicolaou, AC | 1 |
| Baird, TD | 3 |
| Hirsh, SL | 1 |
| Hsu, LL | 1 |
| Ritvo, ER | 6 |
| Freeman, BJ | 6 |
| Yuwiler, A | 6 |
| Geller, E | 6 |
| Yokota, A | 2 |
| Schroth, P | 2 |
| Novak, P | 1 |
| Volkmar, FR | 1 |
| Paul, R | 1 |
| Cohen, DJ | 2 |
| Shaywitz, BA | 1 |
| Hager, T | 1 |
| Ciaranello, RD | 1 |
| Leventhal, BL | 1 |
| Cook, EH | 1 |
| Morford, M | 1 |
| Ravitz, AJ | 1 |
| Heller, W | 1 |
| Freedman, DX | 1 |
| Campbell, M | 6 |
| Schopler, E | 1 |
| Cueva, JE | 1 |
| Hallin, A | 1 |
| Sloman, L | 1 |
| Duker, PC | 1 |
| Welles, K | 1 |
| Seys, D | 1 |
| Rensen, H | 1 |
| Vis, A | 1 |
| van den Berg, G | 1 |
| Oades, RD | 2 |
| Stern, LM | 2 |
| Walker, MK | 2 |
| Clark, CR | 1 |
| Kapoor, V | 1 |
| Sawyer, MG | 1 |
| Badcock, NR | 1 |
| Spence, JG | 1 |
| Varley, CK | 1 |
| Holm, VA | 2 |
| Martineau, J | 2 |
| Barthelemy, C | 3 |
| Roux, S | 2 |
| Garreau, B | 1 |
| Lelord, G | 3 |
| Sherman, J | 1 |
| Factor, DC | 1 |
| Swinson, R | 1 |
| Darjes, RW | 1 |
| Ekman, G | 1 |
| Miranda-Linné, F | 1 |
| Gillberg, C | 1 |
| Garle, M | 1 |
| Wetterberg, L | 1 |
| Aman, MG | 1 |
| Kern, RA | 1 |
| Bruneau, N | 2 |
| Jouve, J | 2 |
| Realmuto, GM | 2 |
| Garfinkel, BD | 1 |
| Muh, JP | 1 |
| McDermott, JF | 1 |
| Pritchard, WS | 2 |
| McBride, PA | 1 |
| Anderson, GM | 1 |
| Hertzig, ME | 1 |
| Sweeney, JA | 1 |
| Kream, J | 1 |
| Mann, JJ | 1 |
| Ho, HH | 1 |
| Lockitch, G | 1 |
| Eaves, L | 1 |
| Jacobson, B | 1 |
| du Verglas, G | 1 |
| Banks, SR | 1 |
| Guyer, KE | 1 |
| Adams, P | 1 |
| Small, AM | 2 |
| Curren, EL | 1 |
| Overall, JE | 1 |
| Anderson, LT | 2 |
| Lynch, N | 1 |
| Perry, R | 4 |
| Ney, P | 1 |
| Neal, T | 1 |
| Manku, MS | 1 |
| Rimland, B | 1 |
| de Villard, R | 1 |
| Ceillier-Hoppenot, B | 1 |
| Flachaire, E | 1 |
| Dalery, J | 1 |
| Rebaud, B | 1 |
| Maillet, J | 1 |
| Revol, O | 1 |
| Mamelle, JC | 1 |
| Quincy, C | 1 |
| Kohler, JA | 1 |
| Shortland, G | 1 |
| Rolles, CJ | 1 |
| Coggins, TE | 1 |
| Morisset, C | 1 |
| Krasney, L | 1 |
| Frederickson, R | 1 |
| Raisys, VA | 1 |
| Sjöholm, B | 1 |
| Sjöholm, M | 1 |
| Reiss, AL | 1 |
| Egel, AL | 1 |
| Feinstein, C | 1 |
| Goldsmith, B | 1 |
| Borengasser-Caruso, MA | 1 |
| Yarbrough, E | 1 |
| Santat, U | 1 |
| Perel, I | 1 |
| Webster, C | 1 |
| Lombardi, R | 1 |
| Groden, G | 1 |
| Groden, J | 1 |
| Dondey, M | 1 |
| Zane, T | 1 |
| Pueschel, SM | 1 |
| Veliceur, W | 1 |
| Beeghly, JH | 1 |
| Kuperman, S | 1 |
| Perry, PJ | 1 |
| Wright, GJ | 1 |
| Tsai, LY | 2 |
| Jensen, J | 1 |
| Klykylo, W | 2 |
| Piggott, L | 1 |
| Stubbs, G | 1 |
| Ritvo, E | 1 |
| Palij, M | 3 |
| Polonsky, BB | 2 |
| Lukashok, D | 2 |
| Gastaut, H | 1 |
| Zifkin, B | 1 |
| Rufo, M | 1 |
| Piggott, LR | 2 |
| Gdowski, CL | 2 |
| Villanueva, D | 1 |
| Fischhoff, J | 2 |
| Frohman, CF | 1 |
| Stubbs, EG | 1 |
| Budden, SS | 1 |
| Jackson, RH | 1 |
| Terdal, LG | 1 |
| Beisler, JM | 1 |
| Stiefel, B | 1 |
| Mason-Brothers, A | 1 |
| Leventhal, B | 1 |
| Deutsch, SI | 2 |
| Wolsky, BB | 1 |
| Hackler, J | 1 |
| Realmuto, G | 1 |
| Killoran, SM | 1 |
| Farber, JM | 1 |
| Gualtieri, CT | 1 |
| Klykylo, WM | 1 |
| Feldis, D | 1 |
| O'Grady, D | 1 |
| Ross, DL | 1 |
| Halloran, C | 1 |
| Pranzatelli, MR | 1 |
| Snodgrass, SR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Double Blind, Randomized, Placebo-Controlled Study of CM-AT for the Treatment of Autism in Children With All Levels of Fecal Chymotrypsin (FCT)[NCT02410902] | Phase 3 | 190 participants (Actual) | Interventional | 2015-05-13 | Completed | ||
| An Open-Label Extension Study of CM-AT for the Treatment of Children With Autism With All Levels of Fecal Chymotrypsin[NCT02649959] | Phase 3 | 405 participants (Anticipated) | Interventional | 2015-10-31 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Primary outcome measurements to determine efficacy of treatment with CM-AT versus Placebo for changes in the Aberrant Behavior Checklist (ABC) - Community sub scale for Irritability/Agitation (ABC-I) between baseline (subject's initial measurement) and Week 12/Termination (subject's final measurement) visit. Participants were between 3 through to 6 years old inclusive and took 900mg CM-AT or Placebo three times daily. The ABC-I is one of five discrete sub scales measured by the ABC. The scale range is 0-45. A higher score reflects higher severity of symptoms (irritability). Scores are obtained via Parent Rated Questionnaire. Parents respond to a series of questions on a scale directly into an electronic data capture system (EDC), responding: 0 = not at all a problem 1 = the behavior is a problem but slight in degree 2 = the problem is moderately serious 3 = the problem is severe in degree. The score was automatically calculated by the EDC. (NCT02410902)
Timeframe: Screening through Week 12/Termination
| Intervention | units on a scale (Mean) |
|---|---|
| CM-AT | -8.0 |
| Placebo | -5.5 |
Secondary outcome measurements to determine efficacy of treatment with CM-AT versus Placebo for changes in the Aberrant Behavior Checklist- Community (ABC) sub scale for Lethargy / Social Withdrawal (ABC-L) between baseline (subject's initial measurement) and Week 12/Termination (subject's final measurement) visit. Participants were between 3 through to 6 years old inclusive and took 900mg CM-AT or Placebo three times daily. The ABC-L is one of five discrete sub scales measured by the ABC. The scale range is 0-48. A higher score reflects higher severity of symptoms (lethargy). Scores are obtained via Parent Rated Questionnaire. Parents respond to a series of questions on a scale directly into an electronic data capture system (EDC), responding: 0 = not at all a problem 1 = the behavior is a problem but slight in degree 2 = the problem is moderately serious 3 = the problem is severe in degree. (NCT02410902)
Timeframe: Screening through Week 12/Termination.
| Intervention | units on a scale (Mean) |
|---|---|
| CM-AT | -7.9 |
| Placebo | -6.6 |
9 reviews available for fenfluramine and Autistic Disorder
| Article | Year |
|---|---|
Selective serotonin reuptake inhibitors (SSRIs) for autism spectrum disorders (ASD).
Topics: Adult; Age Factors; Autistic Disorder; Child; Child Development Disorders, Pervasive; Citalopram; Fe | 2013 |
Selective serotonin reuptake inhibitors (SSRIs) for autism spectrum disorders (ASD).
Topics: Adult; Age Factors; Autistic Disorder; Child; Citalopram; Fenfluramine; Fluoxetine; Fluvoxamine; Hum | 2010 |
Selective serotonin reuptake inhibitors (SSRIs) for autism spectrum disorders (ASD).
Topics: Adult; Age Factors; Autistic Disorder; Child; Citalopram; Fenfluramine; Fluoxetine; Fluvoxamine; Hum | 2010 |
Selective serotonin reuptake inhibitors (SSRIs) for autism spectrum disorders (ASD).
Topics: Adult; Age Factors; Autistic Disorder; Child; Citalopram; Fenfluramine; Fluoxetine; Fluvoxamine; Hum | 2010 |
Selective serotonin reuptake inhibitors (SSRIs) for autism spectrum disorders (ASD).
Topics: Adult; Age Factors; Autistic Disorder; Child; Citalopram; Fenfluramine; Fluoxetine; Fluvoxamine; Hum | 2010 |
Treatment of autistic disorder.
Topics: Antipsychotic Agents; Autistic Disorder; Behavior Therapy; Clomipramine; Clonidine; Fenfluramine; Hu | 1996 |
Use of medication in pervasive developmental disorders.
Topics: Antipsychotic Agents; Attention Deficit Disorder with Hyperactivity; Autistic Disorder; Child; Child | 1991 |
Review of fenfluramine in the treatment of the developmental disabilities.
Topics: Attention Deficit Disorder with Hyperactivity; Autistic Disorder; Child; Clinical Trials as Topic; F | 1989 |
Clinical effects of fenfluramine on children with autism: a review of the research.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Autistic Disorder; Child; Child, Preschoo | 1988 |
Controversies in the treatment of autistic children: vitamin and drug therapy.
Topics: Autistic Disorder; Child; Deanol; Fenfluramine; Humans; Magnesium; Pyridoxine; Thioridazine; Vitamin | 1988 |
[Evaluation of the treatment with fenfluramine of autism in children].
Topics: Ambulatory Care; Autistic Disorder; Child; Drug Evaluation; Female; Fenfluramine; Humans; Male | 1988 |
Fenfluramine treatment of autism.
Topics: Adolescent; Adult; Autistic Disorder; Child; Child, Preschool; Fenfluramine; Humans; Intelligence; S | 1988 |
27 trials available for fenfluramine and Autistic Disorder
| Article | Year |
|---|---|
Fenfluramine treatment in infantile autism. Neurochemical, electrophysiological, and behavioral effects.
Topics: Adolescent; Ambulatory Care; Attention; Autistic Disorder; Brain Stem; Child; Child, Preschool; Clin | 1984 |
Study of fenfluramine in outpatients with the syndrome of autism.
Topics: Adolescent; Autistic Disorder; Body Weight; Child; Child Development; Child, Preschool; Female; Fenf | 1984 |
Clinical and neurochemical effects of fenfluramine in children with autism.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adolescent; Autistic Disorder; Child; Child Behavior Disorders; Chil | 1993 |
Event-related potentials and monoamines in autistic children on a clinical trial of fenfluramine.
Topics: Adolescent; Attention; Autistic Disorder; Biogenic Monoamines; Child; Double-Blind Method; Electroen | 1990 |
A controlled crossover trial of fenfluramine in autism.
Topics: Adolescent; Arousal; Autistic Disorder; Body Weight; Child; Child, Preschool; Double-Blind Method; F | 1990 |
The effects of fenfluramine (hydrochloride) on the behaviors of fifteen autistic children.
Topics: Activities of Daily Living; Adolescent; Autistic Disorder; Child; Double-Blind Method; Female; Fenfl | 1989 |
Fenfluramine treatment of twenty children with autism.
Topics: Autistic Disorder; Child; Child, Preschool; Double-Blind Method; Female; Fenfluramine; Humans; Infan | 1989 |
Review of fenfluramine in the treatment of the developmental disabilities.
Topics: Attention Deficit Disorder with Hyperactivity; Autistic Disorder; Child; Clinical Trials as Topic; F | 1989 |
Auditory evoked potential modifications according to clinical and biochemical responsiveness to fenfluramine treatment in children with autistic behavior.
Topics: 3,4-Dihydroxyphenylacetic Acid; Autistic Disorder; Child; Child, Preschool; Dopamine; Evoked Potenti | 1989 |
Clinical effect of buspirone in autistic children.
Topics: Autistic Disorder; Buspirone; Child; Female; Fenfluramine; Humans; Male; Methylphenidate | 1989 |
Urinary dopamine metabolites as indicators of the responsiveness to fenfluramine treatment in children with autistic behavior.
Topics: 3,4-Dihydroxyphenylacetic Acid; Autistic Disorder; Child; Child, Preschool; Dopamine; Double-Blind M | 1989 |
Effects of fenfluramine on EEG and brainstem average evoked response in infantile autism. Preliminary investigation.
Topics: Adolescent; Autistic Disorder; Brain Stem; Child; Clinical Trials as Topic; Electroencephalography; | 1987 |
Blood serotonin concentrations and fenfluramine therapy in autistic children.
Topics: Adolescent; Analysis of Variance; Attention; Autistic Disorder; Child; Child, Preschool; Clinical Tr | 1986 |
Efficacy and safety of fenfluramine in autistic children.
Topics: Autistic Disorder; Child; Child, Preschool; Clinical Trials as Topic; Discrimination Learning; Femal | 1988 |
Double blind cross-over trial with fenfluramine.
Topics: Autistic Disorder; Child; Clinical Trials as Topic; Double-Blind Method; Female; Fenfluramine; Human | 1988 |
Effect of fenfluramine on autistic symptoms.
Topics: Adolescent; Adult; Autistic Disorder; Behavior; Child; Clinical Trials as Topic; Double-Blind Method | 1987 |
Effects of fenfluramine on social behavior in autistic children.
Topics: Autistic Disorder; Child; Child, Preschool; Female; Fenfluramine; Humans; Hyperkinesis; Male; Social | 1988 |
Fenfluramine response in high and low functioning autistic children.
Topics: Adolescent; Autistic Disorder; Child; Child, Preschool; Clinical Trials as Topic; Double-Blind Metho | 1987 |
Effects of fenfluramine on autistic individuals residing in a state developmental center.
Topics: Adolescent; Adult; Aggression; Autistic Disorder; Child; Clinical Trials as Topic; Double-Blind Meth | 1987 |
Effects of fenfluramine on the behavior of autistic individuals.
Topics: Adolescent; Adult; Attention; Autistic Disorder; Child; Clinical Trials as Topic; Double-Blind Metho | 1987 |
Fenfluramine treatment of autism: relationship of treatment response to blood levels of fenfluramine and norfenfluramine.
Topics: Adolescent; Autistic Disorder; Biotransformation; Child; Clinical Trials as Topic; Double-Blind Meth | 1987 |
Untoward effects of fenfluramine in autistic children.
Topics: Adolescent; Autistic Disorder; Child; Child, Preschool; Clinical Trials as Topic; Double-Blind Metho | 1986 |
The efficacy and safety of fenfluramine in autistic children: preliminary analysis of a double-blind study.
Topics: Autistic Disorder; Child; Child, Preschool; Discrimination Learning; Double-Blind Method; Female; Fe | 1987 |
No effect of chronic fenfluramine on the P300 component of the event-related potential.
Topics: Autistic Disorder; Brain; Child; Evoked Potentials; Fenfluramine; Humans; Male; Reaction Time; Serot | 1987 |
Effects of fenfluramine on eight outpatients with the syndrome of autism.
Topics: Adolescent; Autistic Disorder; Child; Child, Preschool; Double-Blind Method; Female; Fenfluramine; H | 1986 |
Fenfluramine treatment of autism: UCLA collaborative study of 81 patients at nine medical centers.
Topics: Autistic Disorder; Child; Female; Fenfluramine; Humans; Male | 1986 |
Effects of fenfluramine on behavioral, cognitive, and affective disturbances in autistic children.
Topics: Adolescent; Affect; Autistic Disorder; Child; Child, Preschool; Clinical Trials as Topic; Double-Bli | 1985 |
24 other studies available for fenfluramine and Autistic Disorder
| Article | Year |
|---|---|
Effects of fenfluramine on 14 outpatients with the syndrome of autism.
Topics: Adolescent; Autistic Disorder; Child; Child, Preschool; Fenfluramine; Humans; Serotonin | 1983 |
Irritability in autistic children treated with fenfluramine.
Topics: Autistic Disorder; Child; Emotions; Fenfluramine; Humans; Male | 1983 |
Obesity drug, genetic studies renew hope for autism therapy.
Topics: Autistic Disorder; Child; Child, Preschool; Fenfluramine; Genes; Humans; Male; Obesity; Serotonin | 1983 |
Preliminary observations on the effect of fenfluramine on blood serotonin and symptoms in three autistic boys.
Topics: Autistic Disorder; Child, Preschool; Diseases in Twins; Fenfluramine; Humans; Intelligence Tests; Ma | 1982 |
Hyperserotonemia and early infantile autism.
Topics: Autistic Disorder; Child; Diagnosis, Differential; Fenfluramine; Humans; Infant; Serotonin | 1982 |
Fenfluramine in autism.
Topics: Adult; Autistic Disorder; Brain Chemistry; Child; Fenfluramine; Humans; Pilot Projects; Serotonin | 1982 |
Brief report: effects of fenfluramine on communicative, stereotypic, and inappropriate behaviors of autistic-type mentally handicapped individuals.
Topics: Adolescent; Adult; Autistic Disorder; Child; Communication; Female; Fenfluramine; Humans; Intellectu | 1991 |
A two-year follow-up of autistic children treated with fenfluramine.
Topics: Adolescent; Autistic Disorder; Child; Drug Tolerance; Female; Fenfluramine; Follow-Up Studies; Human | 1990 |
Electrophysiological effects of fenfluramine or combined vitamin B6 and magnesium on children with autistic behaviour.
Topics: Autistic Disorder; Brain; Child; Child, Preschool; Evoked Potentials, Auditory; Female; Fenfluramine | 1989 |
Elvis Presley and the Rieger Award.
Topics: Autistic Disorder; Awards and Prizes; Child; Child Behavior Disorders; Fenfluramine; Humans; Psychia | 1989 |
Serotonergic responsivity in male young adults with autistic disorder. Results of a pilot study.
Topics: Adult; Autistic Disorder; Blood Platelets; Fenfluramine; Humans; Male; Pilot Projects; Platelet Aggr | 1989 |
Brief report: does fenfluramine treatment enhance the cognitive and communicative functioning of autistic children?
Topics: Autistic Disorder; Cognition; Communication; Double-Blind Method; Female; Fenfluramine; Humans; Long | 1988 |
Adverse effects of fenfluramine.
Topics: Animals; Autistic Disorder; Brain Diseases; Child; Fenfluramine; Humans | 1988 |
Compulsive respiratory stereotypies in children with autistic features: polygraphic recording and treatment with fenfluramine.
Topics: Apnea; Autistic Disorder; Child; Child, Preschool; Compulsive Behavior; Electrocardiography; Electro | 1987 |
Side effects of fenfluramine in autistic children.
Topics: Adolescent; Autistic Disorder; Child; Child, Preschool; Dose-Response Relationship, Drug; Fenflurami | 1986 |
The effects of fenfluramine on communication skills in autistic children.
Topics: Adolescent; Autistic Disorder; Child; Communication; Echolalia; Fenfluramine; Humans; Language; Male | 1986 |
Short-term efficacy and safety of fenfluramine in hospitalized preschool-age autistic children: an open study.
Topics: Autistic Disorder; Child, Preschool; Female; Fenfluramine; Humans; Male; Pilot Projects; Psychiatric | 1986 |
[Treatment of compulsive eating disorders in an autistic girl by combining behavior therapy and pharmacotherapy. Case report].
Topics: Adolescent; Autistic Disorder; Behavior Therapy; Combined Modality Therapy; Compulsive Behavior; Die | 1986 |
Reappraisal of "Fenfluramine and autism: careful reappraisal is in order".
Topics: Autistic Disorder; Child; Fenfluramine; Humans | 1987 |
An open study of fenfluramine in hospitalized young autistic children.
Topics: Aggression; Autistic Disorder; Child, Preschool; Female; Fenfluramine; Humans; Intelligence; Male; S | 1986 |
Fenfluramine and autism.
Topics: Autistic Disorder; Child; Fenfluramine; Humans | 1986 |
Fenfluramine and autism: careful reappraisal is in order.
Topics: Autistic Disorder; Child; Drug Evaluation; Fenfluramine; Humans | 1986 |
Clinical effects of fenfluramine in ten autistic subjects.
Topics: Autistic Disorder; Child; Echolalia; Fenfluramine; Humans; Male; Serotonin; Sleep Stages | 1985 |
Fenfluramine therapy for autism.
Topics: Autistic Disorder; Fenfluramine; Humans; Neurons | 1985 |