fenfluramine has been researched along with Asystole in 4 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report a case of pulmonary hypertension presenting with sudden cardiac arrest, hyperthyroidism and fenfluramine usage." | 8.83 | Pulmonary hypertension, hyperthyroidism, and fenfluramine: a case report and review. ( Chan, CK; Leung, YY; Tang, KS; Tsang, CC; Wong, KK; Yu, AW, 2006) |
| "Fenfluramine is a substituted phenylethylamine structurally related to amphetamine." | 5.25 | Fenfluramine poisoning. ( Temple, AR; Veltri, JC, 1975) |
| "We report a case of pulmonary hypertension presenting with sudden cardiac arrest, hyperthyroidism and fenfluramine usage." | 4.83 | Pulmonary hypertension, hyperthyroidism, and fenfluramine: a case report and review. ( Chan, CK; Leung, YY; Tang, KS; Tsang, CC; Wong, KK; Yu, AW, 2006) |
| "Fenfluramine is a substituted phenylethylamine structurally related to amphetamine." | 1.25 | Fenfluramine poisoning. ( Temple, AR; Veltri, JC, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (75.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Leung, YY | 1 |
| Tang, KS | 1 |
| Tsang, CC | 1 |
| Chan, CK | 1 |
| Wong, KK | 1 |
| Yu, AW | 1 |
| Winnie, AP | 1 |
| Bennett, JA | 1 |
| Eltringham, RJ | 1 |
| Veltri, JC | 1 |
| Temple, AR | 1 |
1 review available for fenfluramine and Asystole
| Article | Year |
|---|---|
Pulmonary hypertension, hyperthyroidism, and fenfluramine: a case report and review.
Topics: Fatal Outcome; Female; Fenfluramine; Heart Arrest; Humans; Hypertension, Pulmonary; Hyperthyroidism; | 2006 |
3 other studies available for fenfluramine and Asystole
| Article | Year |
|---|---|
Fenfluramine and halothane.
Topics: Anesthesia, Inhalation; Animals; Drug Interactions; Fenfluramine; Halothane; Heart Arrest; Humans | 1979 |
Possible dangers of anaesthesia in patients receiving fenfluramine. Results of animal studies following a case of human cardiac arrest.
Topics: Adult; Anesthesia, General; Animals; Drug Interactions; Epinephrine; Female; Fenfluramine; Halothane | 1977 |
Fenfluramine poisoning.
Topics: Adolescent; Arrhythmias, Cardiac; Autopsy; Electrocardiography; Female; Fenfluramine; Heart Arrest; | 1975 |