fenfluramine has been researched along with Astrocytosis in 2 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tiraboschi, E | 1 |
| Martina, S | 1 |
| van der Ent, W | 1 |
| Grzyb, K | 1 |
| Gawel, K | 1 |
| Cordero-Maldonado, ML | 1 |
| Poovathingal, SK | 1 |
| Heintz, S | 1 |
| Satheesh, SV | 1 |
| Brattespe, J | 1 |
| Xu, J | 1 |
| Suster, M | 1 |
| Skupin, A | 1 |
| Esguerra, CV | 1 |
| Stewart, CW | 1 |
| Slikker, W | 1 |
2 other studies available for fenfluramine and Astrocytosis
| Article | Year |
|---|---|
New insights into the early mechanisms of epileptogenesis in a zebrafish model of Dravet syndrome.
Topics: Animals; Anticonvulsants; Brain; Cell Proliferation; CRISPR-Cas Systems; Diazepam; Disease Models, A | 2020 |
Hyperthermia-enhanced serotonin (5-HT) depletion resulting from D-fenfluramine (D-Fen) exposure does not evoke a glial-cell response in the central nervous system of rats.
Topics: Animals; Brain Chemistry; Fenfluramine; Fever; Frontal Lobe; Glial Fibrillary Acidic Protein; Gliosi | 1999 |