fenfluramine has been researched along with As If Personality in 25 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hormonal responses to challenge with the 5-HT2A/2C probe d-fenfluramine and hormonal and thermal responses to challenge with the 5-HT1A probe ipsapirone were correlated with self-report and historical assessments of aggression in a pilot sample of eight male personality-disordered individuals." | 7.69 | Physiological responses to d-fenfluramine and ipsapirone challenge correlate with indices of aggression in males with personality disorder. ( Coccaro, EF; Hauger, RL; Kavoussi, RJ, 1995) |
| "Prolactin (PRL) responses to acute challenge with the serotonin (5-HT) releaser/uptake inhibitor, d-fenfluramine (PRL[d-FEN]), were correlated with three different measures of aggression in 14 male personality-disordered subjects." | 7.69 | Relationship of prolactin response to d-fenfluramine to behavioral and questionnaire assessments of aggression in personality-disordered men. ( Berman, ME; Coccaro, EF; Hauger, RL; Kavoussi, RJ, 1996) |
| "This study compared the nature and magnitude of the relationship between aggression and CSF 5-hydroxyindoleacetic acid (5-HIAA) concentration with that between aggression and the prolactin response to d-fenfluramine challenge in human subjects." | 7.69 | Central serotonin activity and aggression: inverse relationship with prolactin response to d-fenfluramine, but not CSF 5-HIAA concentration, in human subjects. ( Coccaro, EF; Cooper, TB; Hauger, RL; Kavoussi, RJ, 1997) |
| "Sixty male offenders with DSM-III-R personality disorders and 27 healthy staff controls were assessed using the Special Hospital Assessment of Personality and Socialisation (SHAPS), impulsivity and aggression ratings, d-fenfluramine challenge and plasma hormone concentrations." | 3.71 | Relationship between 5-HT function and impulsivity and aggression in male offenders with personality disorders. ( Anderson, IM; Deakin, JF; Dolan, M, 2001) |
| "The CSF AVP level was correlated directly with life history of general aggression and aggression against persons and inversely with PRL[d-FEN] responses (but not with CSF 5-hydroxyindoleacetic acid), which in turn was correlated inversely with these 2 measures of life history of aggression." | 3.70 | Cerebrospinal fluid vasopressin levels: correlates with aggression and serotonin function in personality-disordered subjects. ( Coccaro, EF; Cooper, TB; Ferris, CF; Hauger, RL; Kavoussi, RJ, 1998) |
| " All subjects were administered standard interview and questionnaire indices of aggression and anger-related traits of personality; in a portion of subjects, CNS serotonergic activity was assessed by neuropsychopharmacologic challenge (prolactin response to fenfluramine hydrochloride)." | 3.70 | Aggression and anger-related traits associated with a polymorphism of the tryptophan hydroxylase gene. ( Dent, KM; Ferrell, RE; Flory, JD; Mann, JJ; Manuck, SB; Muldoon, MF, 1999) |
| "Hormonal responses to challenge with the 5-HT2A/2C probe d-fenfluramine and hormonal and thermal responses to challenge with the 5-HT1A probe ipsapirone were correlated with self-report and historical assessments of aggression in a pilot sample of eight male personality-disordered individuals." | 3.69 | Physiological responses to d-fenfluramine and ipsapirone challenge correlate with indices of aggression in males with personality disorder. ( Coccaro, EF; Hauger, RL; Kavoussi, RJ, 1995) |
| "Prolactin (PRL) responses to acute challenge with the serotonin (5-HT) releaser/uptake inhibitor, d-fenfluramine (PRL[d-FEN]), were correlated with three different measures of aggression in 14 male personality-disordered subjects." | 3.69 | Relationship of prolactin response to d-fenfluramine to behavioral and questionnaire assessments of aggression in personality-disordered men. ( Berman, ME; Coccaro, EF; Hauger, RL; Kavoussi, RJ, 1996) |
| "This study compared serotonergic function, as assessed by prolactin response to fenfluramine, in males with compulsive personality disorder, males with noncompulsive personality disorders, and normal control subjects." | 3.69 | Impulsivity and serotonergic function in compulsive personality disorder. ( Coccaro, EF; Hollander, E; Mitropoulou, V; Siever, LJ; Stein, DJ; Trestman, RL, 1996) |
| "This study compared the nature and magnitude of the relationship between aggression and CSF 5-hydroxyindoleacetic acid (5-HIAA) concentration with that between aggression and the prolactin response to d-fenfluramine challenge in human subjects." | 3.69 | Central serotonin activity and aggression: inverse relationship with prolactin response to d-fenfluramine, but not CSF 5-HIAA concentration, in human subjects. ( Coccaro, EF; Cooper, TB; Hauger, RL; Kavoussi, RJ, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (16.00) | 18.7374 |
| 1990's | 17 (68.00) | 18.2507 |
| 2000's | 3 (12.00) | 29.6817 |
| 2010's | 1 (4.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Coccaro, EF | 15 |
| Lee, R | 1 |
| Kavoussi, RJ | 7 |
| Birger, M | 1 |
| Swartz, M | 1 |
| Cohen, D | 1 |
| Alesh, Y | 1 |
| Grishpan, C | 1 |
| Kotelr, M | 1 |
| Klar, H | 2 |
| Siever, LJ | 9 |
| Silverman, JM | 1 |
| Klar, HM | 2 |
| Horvath, TB | 1 |
| Myers, JE | 1 |
| Mieczkowski, T | 1 |
| Perel, J | 1 |
| Abbondanza, D | 1 |
| Cooper, TB | 5 |
| Mann, JJ | 3 |
| Hauger, RL | 5 |
| Berman, ME | 1 |
| Malone, KM | 1 |
| Corbitt, EM | 1 |
| Li, S | 1 |
| New, AS | 2 |
| Trestman, RL | 4 |
| Mitropoulou, V | 3 |
| Benishay, DS | 1 |
| Coccaro, E | 1 |
| Silverman, J | 1 |
| Stein, DJ | 1 |
| Hollander, E | 1 |
| Gabriel, SM | 1 |
| Ferris, CF | 1 |
| Manuck, SB | 1 |
| Flory, JD | 1 |
| Ferrell, RE | 1 |
| Dent, KM | 1 |
| Muldoon, MF | 1 |
| Buchsbaum, MS | 1 |
| Spiegel-Cohen, J | 1 |
| Wei, T | 1 |
| Hazlett, EA | 1 |
| Sevin, E | 1 |
| Nunn, M | 1 |
| Dolan, M | 2 |
| Anderson, IM | 1 |
| Deakin, JF | 1 |
| Deakin, WJ | 1 |
| Roberts, N | 1 |
| Anderson, I | 1 |
| Gabriel, S | 1 |
| Harvey, PD | 1 |
| Kupsaw-Lawrence, E | 1 |
| Herbert, JL | 1 |
| Bernstein, DP | 1 |
| Maurer, G | 1 |
| Cochrane, K | 1 |
| Mohs, RC | 1 |
| Davis, KL | 2 |
| Rubenstein, K | 1 |
| Benjamin, E | 1 |
| Goldrick, RB | 1 |
| Havenstein, N | 1 |
| Whyte, HM | 1 |
| Gaind, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Pimavanserin on Aggression and Social Cognition.[NCT05895513] | Phase 2 | 35 participants (Anticipated) | Interventional | 2024-01-31 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for fenfluramine and As If Personality
| Article | Year |
|---|---|
Aggression: the testosterone-serotonin link.
Topics: Aggression; Animals; Female; Fenfluramine; Humans; Hydroxyindoleacetic Acid; Macaca mulatta; Male; P | 2003 |
Impulsive aggression and central serotonergic system function in humans: an example of a dimensional brain-behavior relationship.
Topics: Affective Disorders, Psychotic; Aggression; Brain Chemistry; Fenfluramine; Humans; Impulsive Behavio | 1992 |
6 trials available for fenfluramine and As If Personality
| Article | Year |
|---|---|
Aggression, suicidality, and intermittent explosive disorder: serotonergic correlates in personality disorder and healthy control subjects.
Topics: Adult; Aggression; Analysis of Variance; Disruptive, Impulse Control, and Conduct Disorders; Female; | 2010 |
Reduced prolactin response to fenfluramine challenge in personality disorder patients is not due to deficiency of pituitary lactotrophs.
Topics: Adult; Borderline Personality Disorder; Fenfluramine; Humans; Hypothalamo-Hypophyseal System; Male; | 1994 |
Serotonin function and antiaggressive response to fluoxetine: a pilot study.
Topics: Adolescent; Adolescent Behavior; Adult; Aggression; Double-Blind Method; Fenfluramine; Fluoxetine; H | 1997 |
d,l-fenfluramine response in impulsive personality disorder assessed with [18F]fluorodeoxyglucose positron emission tomography.
Topics: Adult; Aggression; Brain Chemistry; Brain Mapping; Female; Fenfluramine; Fluorodeoxyglucose F18; Hum | 1999 |
Effects of caloric restriction and fenfluramine on weight loss and personality profiles of patients with long standing obesity.
Topics: Adolescent; Adult; Aged; Body Weight; Clinical Trials as Topic; Diet, Reducing; Drug Tolerance; Feed | 1973 |
Fenfluramine (Ponderax) in the treatment of obese psychiatric out-patients.
Topics: Anxiety Disorders; Appetite Depressants; Body Weight; Clinical Trials as Topic; Depression; Diarrhea | 1969 |
17 other studies available for fenfluramine and As If Personality
| Article | Year |
|---|---|
Familial correlates of reduced central serotonergic system function in patients with personality disorders.
Topics: Aggression; Alcoholism; Family; Fenfluramine; Humans; Impulsive Behavior; Male; Personality Disorder | 1994 |
Abnormal behavioral responses to fenfluramine in patients with affective and personality disorders. Correlation with increased serotonergic responsivity.
Topics: Adult; Anxiety; Arousal; Brain; Depressive Disorder; Female; Fenfluramine; Humans; Male; Middle Aged | 1994 |
Physiological responses to d-fenfluramine and ipsapirone challenge correlate with indices of aggression in males with personality disorder.
Topics: Adult; Aggression; Behavior; Fenfluramine; Humans; Male; Personality Disorders; Pyrimidines; Seroton | 1995 |
Relationship of prolactin response to d-fenfluramine to behavioral and questionnaire assessments of aggression in personality-disordered men.
Topics: Adult; Aggression; Fenfluramine; Humans; Male; Middle Aged; Personality Disorders; Prolactin; Psychi | 1996 |
Prolactin response to fenfluramine and suicide attempt lethality in major depression.
Topics: Adult; Body Weight; Depressive Disorder; Female; Fenfluramine; Humans; Hydrocortisone; Longitudinal | 1996 |
Serotonergic function and self-injurious behavior in personality disorder patients.
Topics: Adult; Female; Fenfluramine; Humans; Hydrocortisone; Male; Personality Disorders; Prolactin; Selecti | 1997 |
Impulsivity and serotonergic function in compulsive personality disorder.
Topics: Adult; Compulsive Personality Disorder; Fenfluramine; Humans; Impulsive Behavior; Male; Middle Aged; | 1996 |
Central serotonin activity and aggression: inverse relationship with prolactin response to d-fenfluramine, but not CSF 5-HIAA concentration, in human subjects.
Topics: Adult; Aggression; Brain; Female; Fenfluramine; Humans; Hydroxyindoleacetic Acid; Male; Personality | 1997 |
Serotonin function in human subjects: intercorrelations among central 5-HT indices and aggressiveness.
Topics: Adult; Aggression; Depression; Female; Fenfluramine; Humans; Male; Middle Aged; Personality Disorder | 1997 |
Cerebrospinal fluid vasopressin levels: correlates with aggression and serotonin function in personality-disordered subjects.
Topics: Adult; Aggression; Arginine Vasopressin; Female; Fenfluramine; Humans; Hydroxyindoleacetic Acid; Imp | 1998 |
Aggression and anger-related traits associated with a polymorphism of the tryptophan hydroxylase gene.
Topics: Aggression; Alleles; Anger; Female; Fenfluramine; Genotype; Homozygote; Humans; Male; Personality Di | 1999 |
Relationship between 5-HT function and impulsivity and aggression in male offenders with personality disorders.
Topics: Adult; Aggression; Fenfluramine; Humans; Hydrocortisone; Impulsive Behavior; Male; Personality Disor | 2001 |
Serotonergic and cognitive impairment in impulsive aggressive personality disordered offenders: are there implications for treatment?
Topics: Adult; Aggression; Analysis of Variance; Cluster Analysis; Fenfluramine; Humans; Hydrocortisone; Imp | 2002 |
Use of serotonin-active agents in other psychiatric disorders.
Topics: Aggression; Fenfluramine; Humans; Impulsive Behavior; Male; Mental Disorders; Personality Disorders; | 1992 |
Development of neuropharmacologically based behavioral assessments of impulsive aggressive behavior.
Topics: Adult; Aggression; Anger; Depressive Disorder; Female; Fenfluramine; Humans; Hypothalamus; Impulsive | 1991 |
Serotonergic studies in patients with affective and personality disorders. Correlates with suicidal and impulsive aggressive behavior.
Topics: Adult; Aggression; Alcoholism; Depressive Disorder; Fenfluramine; Humans; Impulsive Behavior; Male; | 1989 |
Diminished prolactin responses to repeated fenfluramine challenge in man.
Topics: Adult; Aged; Depressive Disorder; Fenfluramine; Humans; Male; Middle Aged; Personality Disorders; Pr | 1987 |