fenfluramine has been researched along with Arteriosclerosis in 4 studies
Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.
Arteriosclerosis: Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries.
| Excerpt | Relevance | Reference |
|---|---|---|
| "D-fenfluramine treatment markedly improved the maximum relaxant response of aortic rings to acetylcholine, indicating improvement of the defective endothelium-derived relaxation factor system." | 5.30 | Improvement of insulin sensitivity and cardiovascular outcomes in the JCR:LA-cp rat by D-fenfluramine. ( Amy, RM; Brindley, DN; Dolphin, PJ; Graham, SE; Russell, JC, 1998) |
| " Benfluorex treatment improves insulin sensitivity and has antihyperglycemic and hypolipidemic effects in human beings and in experimental animals." | 4.78 | [Mode of action of benfluorex. Recent data]. ( Brindley, DN, 1992) |
| " Benfluorex has both anorectic and metabolic effects that lower body weight and improve insulin sensitivity in obesity and type 2 diabetes." | 3.69 | Antiatherogenic effects of long-term benfluorex treatment in male insulin resistant JCR:LA-cp rats. ( Amy, RM; Brindley, DN; Dolphin, PJ; Graham, SE; Russell, JC; Wood, GO, 1997) |
| "D-fenfluramine treatment markedly improved the maximum relaxant response of aortic rings to acetylcholine, indicating improvement of the defective endothelium-derived relaxation factor system." | 1.30 | Improvement of insulin sensitivity and cardiovascular outcomes in the JCR:LA-cp rat by D-fenfluramine. ( Amy, RM; Brindley, DN; Dolphin, PJ; Graham, SE; Russell, JC, 1998) |
| "Benfluorex-treated animals showed significant decreases in glucose intolerance, hyperinsulinemia, hypertriglyceridemia, hypercholesterolemia, and plasma LDL- and VLDL-cholesterol, with no evidence of aortic atheroma." | 1.30 | Metabolic and anti-atherogenic effects of long-term benfluorex in dyslipidemic insulin-resistant sand rats (Psammomys obesus). ( Bennani, N; El Madani, T; Hadjiisky, P; Marquié, G; Pieraggi, MT; Ravel, D; Seguin, L; Solera, ML, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Russell, JC | 2 |
| Graham, SE | 2 |
| Dolphin, PJ | 2 |
| Amy, RM | 2 |
| Wood, GO | 1 |
| Brindley, DN | 3 |
| Marquié, G | 1 |
| El Madani, T | 1 |
| Solera, ML | 1 |
| Pieraggi, MT | 1 |
| Hadjiisky, P | 1 |
| Ravel, D | 1 |
| Seguin, L | 1 |
| Bennani, N | 1 |
1 review available for fenfluramine and Arteriosclerosis
| Article | Year |
|---|---|
[Mode of action of benfluorex. Recent data].
Topics: Animals; Arteriosclerosis; Diabetes Mellitus, Type 2; Drug Interactions; Fatty Acids; Female; Fenflu | 1992 |
3 other studies available for fenfluramine and Arteriosclerosis
| Article | Year |
|---|---|
Antiatherogenic effects of long-term benfluorex treatment in male insulin resistant JCR:LA-cp rats.
Topics: Animals; Arteriosclerosis; Fenfluramine; Hypolipidemic Agents; Insulin Resistance; Male; Obesity; Ra | 1997 |
Improvement of insulin sensitivity and cardiovascular outcomes in the JCR:LA-cp rat by D-fenfluramine.
Topics: Acetylcholine; Animals; Aorta; Aorta, Thoracic; Aortic Diseases; Appetite Depressants; Arteriosclero | 1998 |
Metabolic and anti-atherogenic effects of long-term benfluorex in dyslipidemic insulin-resistant sand rats (Psammomys obesus).
Topics: Animal Nutritional Physiological Phenomena; Animals; Aorta; Arteriosclerosis; Body Weight; Cholester | 1998 |